TROPICAMIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H20N2O2
Molecular Weight	284.3529
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2

InChI

InChIKey=BGDKAVGWHJFAGW-UHFFFAOYSA-N

InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3

HIDE SMILES / InChI

Molecular Formula	C17H20N2O2
Molecular Weight	284.3529
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description

Tropicamide (Mydriacyl) is an anticholinergic used as a mydriatic.Tropicamide belongs to the group of medicines called anti-muscarinics. Tropicamide blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved controlling the pupil size and the shape of the lens. By blocking these receptors, tropicamide produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia). Tropicamide is given as eye drops to dilate the pupil and relax the lens so that eye examinations can be carried out thoroughly.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Melanocortin receptor 4 5	Antagonist 2,778		6.86 null [pKi]
Muscarinic acetylcholine receptor M3 159	Antagonist 2,778		6.99 null [pKi]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Eye diseases 25	Diagnostic		Approved 8,429	MYDRIACYL

C_max

Value	Dose	Co-administered	Analyte	Population
2.8 ng/mL	400 μg single, ocular		TROPICAMIDE plasma	Homo sapiens

T_1/2

Value	Dose	Co-administered	Analyte	Population
30 min	unknown		TROPICAMIDE plasma	Homo sapiens

Sourcing

Sourcing

Show entries

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B2-5180	http://www.3bsc.com/index/pro_info.php?id=83219
AA Blocks	AA007XBN	http://www.aablocks.com/goods/Goods/detail?id=AA007XBN
Aaron Chemicals	AR007Y3F	http://www.aaronchem.com/1508-75-4
abcr GmbH	AB251831	http://www.abcr.com/shop/en/AB251831
AbMole Bioscience	M6040	http://www.abmole.com/products/tropicamide.html

Showing 1 to 5 of 53 entries

Previous1 2 3 4 5…11Next

PubMed

Show entries

Title	Date	PubMed
[Ocular hypertension induced by tropicamide after treatment of the angle with argon laser].	1985	3833883
Muscarinic binding sites of the pig intravesical ureter.	1995 Oct	8744975
Pupil dilatation assay by tropicamide is modulated by apolipoprotein E epsilon 4 allele dosage in Alzheimer's disease.	1996 Mar 22	8724673
Apolipoprotein E epsilon 4 allele and pupillary response to tropicamide.	1997 May	9137131
Identification of muscarinic receptor subtypes in RINm5F cells by means of polymerase chain reaction, subcloning, and DNA sequencing.	1997 Sep	9287041

Showing 1 to 5 of 22 entries

Previous1 2 3 4 5Next

Patents

Sample Use Guides

In Vivo Use Guide

Usual Adult Dose for Refraction Cycloplegic Refraction: -Instill 1 or 2 drops of the 1% solution into eye(s); repeat in 5 minutes. Comment: -An additional drop may be given if the examination is not done within 20 to 30 minutes. Usual Adult Dose for Pupillary Dilation Fundoscopy: -Instill 1 or 2 drops of 0.5% solution into eye(s) 15 or 20 minutes prior to examination. Comments: -Heavily pigmented irides may require higher strength or more doses. Usual Pediatric Dose for Refraction Cycloplegic Refraction: -Instill 1 or 2 drops of the 1% solution into eye(s); repeat in 5 minutes.

Route of Administration: Topical

In Vitro Use Guide

The muscarine action on GABAergic mIPSC frequency was completely blocked by 1 uM tropicamide in rat tuberomammillary nucleus neurons.

Substance Class	Chemical
Record UNII	N0A3Z5XTC6
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

TROPICAMIDE

Official Name

English

tropicamide [INN]

Common Name

English

Tropicamide [WHO-DD]

Common Name

English

RO-1-7683

Code

English

NSC-757372

Code

English

Showing 1 to 5 of 26 entries

Previous1 2 3 4 5 6Next

Show entries

Classification Tree

Code System

Code

Reagent

NCI_THESAURUS

C1937

Anticholinergics

WHO-VATC

QS01FA06

Anticholinergic Agent

NCI_THESAURUS

C29704

Diagnostic agents

WHO-ESSENTIAL MEDICINES LIST

14.1

Established Pharmacologic Class

NDF-RT

N0000175574

Showing 1 to 5 of 9 entries

Previous1 2Next

Show entries

Code System

Code

Type

Description

WHO INTERNATIONAL PHARMACOPEIA

TROPICAMIDE

PRIMARY

Description: A white or almost white, crystalline powder. Solubility: Slightly soluble in water; freely soluble in dichloromethane R and ethanol (~750 g/l) TS. Category: Mydriatic. Storage: Tropicamide should be kept in a tightly closed container, protected from light. Labelling: The designation Tropicamide for sterile non-injectable use indicates that the substance complies with the additional requirement and may be used for sterile applications. Expiry date. Requirement: Tropicamide contains not less than 99.0% and not more than 101.0% of C17H20N2O2, calculated with reference to the dried substance.

ECHA (EC/EINECS)

216-140-2

PRIMARY

DRUG CENTRAL

2774

PRIMARY

INN

1059

PRIMARY

RS_ITEM_NUM

1699005

PRIMARY