Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C17H20N2O2.ClH |
| Molecular Weight | 320.814 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
InChI
InChIKey=JQIPVEBSCXNGIG-UHFFFAOYSA-N
InChI=1S/C17H20N2O2.ClH/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15;/h3-11,16,20H,2,12-13H2,1H3;1H
| Molecular Formula | C17H20N2O2 |
| Molecular Weight | 284.3529 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including https://www.drugs.com/pro/tropicamide.html
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/pro/tropicamide.html
Tropicamide (Mydriacyl) is an anticholinergic used as a mydriatic.Tropicamide belongs to the group of medicines called anti-muscarinics. Tropicamide blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved controlling the pupil size and the shape of the lens. By blocking these receptors, tropicamide produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia). Tropicamide is given as eye drops to dilate the pupil and relax the lens so that eye examinations can be carried out thoroughly.
CNS Activity
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
28.9 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32320311 |
0.5 % single, ocular dose: 0.5 % route of administration: Ocular experiment type: SINGLE co-administered: PHENYLEPHRINE |
TROPICAMIDE plasma | Oryctolagus cuniculus population: HEALTHY age: ADULT sex: UNKNOWN food status: FED |
|
2.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8083562 |
400 μg single, ocular dose: 400 μg route of administration: Ocular experiment type: SINGLE co-administered: |
TROPICAMIDE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
25.1 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32320311 |
0.5 % single, ocular dose: 0.5 % route of administration: Ocular experiment type: SINGLE co-administered: PHENYLEPHRINE |
TROPICAMIDE plasma | Oryctolagus cuniculus population: HEALTHY age: ADULT sex: UNKNOWN food status: FED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
30 min |
unknown |
TROPICAMIDE unknown | Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
Funbound
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
55% |
TROPICAMIDE unknown | Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Ocular hypertension induced by tropicamide after treatment of the angle with argon laser]. | 1985 |
|
| Muscarinic binding sites of the pig intravesical ureter. | 1995 Oct |
|
| Identification of muscarinic receptor subtypes in RINm5F cells by means of polymerase chain reaction, subcloning, and DNA sequencing. | 1997 Sep |
|
| The effect of pupil dilation with tropicamide on vision and driving simulator performance. | 2000 Jun |
|
| Search of antimicrobial activity of selected non-antibiotic drugs. | 2002 Nov-Dec |
|
| A double-blind study comparing 0.5% and 1% tropicamide for annual retinal screening in diabetic adolescents. | 2004 May |
|
| Neuronal nitric oxide synthase activity in rat urinary bladder detrusor: participation in M3 and M4 muscarinic receptor function. | 2005 Jul |
|
| Why patients with Alzheimer's disease may show increased sensitivity to tropicamide eye drops: role of locus coeruleus. | 2006 Jan |
|
| Corticotropin-releasing factor inhibition of sheep fetal colonic contractility: mechanisms to prevent meconium passage in utero. | 2007 Apr |
|
| Transcriptional up-regulation of nitric oxide synthase II by nuclear factor-kappaB at rostral ventrolateral medulla in a rat mevinphos intoxication model of brain stem death. | 2007 Jun 15 |
|
| Functional expression of M3, a muscarinic acetylcholine receptor subtype, in taste bud cells of mouse fungiform papillae. | 2008 Jan |
Patents
Sample Use Guides
Usual Adult Dose for Refraction
Cycloplegic Refraction:
-Instill 1 or 2 drops of the 1% solution into eye(s); repeat in 5 minutes.
Comment:
-An additional drop may be given if the examination is not done within 20 to 30 minutes. Usual Adult Dose for Pupillary Dilation
Fundoscopy:
-Instill 1 or 2 drops of 0.5% solution into eye(s) 15 or 20 minutes prior to examination.
Comments:
-Heavily pigmented irides may require higher strength or more doses.
Usual Pediatric Dose for Refraction
Cycloplegic Refraction:
-Instill 1 or 2 drops of the 1% solution into eye(s); repeat in 5 minutes.
Route of Administration:
Topical
| Substance Class |
Chemical
Created
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admin
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Edited
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by
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Sat Dec 16 10:21:10 GMT 2023
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| Record UNII |
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| Record Status |
Validated (UNII)
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