U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C4H7N3O
Molecular Weight 113.1179
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CREATININE

SMILES

CN1CC(=O)N=C1N

InChI

InChIKey=DDRJAANPRJIHGJ-UHFFFAOYSA-N
InChI=1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)

HIDE SMILES / InChI
Molecular Formula C4H7N3O
Molecular Weight 113.1179
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Creatinine is a product of metabolism of creatine phosphate, a molecule that serves as a rapidly mobilizable reserve of a brain and skeletal muscle. Creatinine is excreted by kidneys with little or no reabsorption. Serum creatinine is the most commonly used indicator of renal function.

CNS Activity

Originator

Approval Year

1996
225
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Natural Metabolite
Unknown

Approved Use

Unknown
Inactive ingredient
Approved
8429
AGELOC TRANSFORMATION

Approved Use

Helps to prevent sunburn.

Launch Date

2013
PubMed

PubMed

TitleDatePubMed
Urinary F2-isoprostanes formation in kidney transplantation.
2001 Feb
Hyperlipidemia as a risk factor of renal allograft function impairment.
2001 Feb
Cyclosporine challenge test revisited: does it predict outcome after solitary pancreas transplantation?
2001 Feb
Diagnosis of kidney transplant obstruction using Mag3 diuretic renography.
2001 Feb
Influence of aspirin on early allograft thrombosis and chronic allograft nephropathy following renal transplantation.
2001 Feb
Hypoglycemic effect of the water extract of Smallantus sonchifolius (yacon) leaves in normal and diabetic rats.
2001 Feb
The effect of growth hormone on 24-h urinary creatinine levels in burned patients.
2001 Feb
Angiotensin converting enzyme inhibitor induced hyperkalaemic paralysis.
2001 Feb
Prospective study of hepatic, renal, and haematological surveillance in hazardous materials firefighters.
2001 Feb
Predictors of DMSA chelatable lead, tibial lead, and blood lead in 802 Korean lead workers.
2001 Feb
Urinary thromboxane, prostacyclin, cortisol, and 8-hydroxy-2'-deoxyguanosine in nonsmokers exposed and not exposed to environmental tobacco smoke.
2001 Feb
Brain proton magnetic resonance spectroscopy and imaging in children exposed to cocaine in utero.
2001 Feb
Human SA gene Pst1 polymorphism and chronic renal failure: results of the family-based study.
2001 Feb
Laparoscopic or open surgery for living donor nephrectomy.
2001 Feb
Effect of closure of the arteriovenous fistula on left ventricular dimensions in renal transplant patients.
2001 Feb
Effects of continuous haemofiltration vs intermittent haemodialysis on systemic haemodynamics and splanchnic regional perfusion in septic shock patients: a prospective, randomized clinical trial.
2001 Feb
Beneficial influence of recombinant human erythropoietin therapy on the rate of progression of chronic renal failure in predialysis patients.
2001 Feb
Impaired endothelium-dependent vasodilatation in renal failure in humans.
2001 Feb
Variation in the progression of diabetic nephropathy according to racial origin.
2001 Feb
Circulating soluble adhesion molecules in ANCA-associated vasculitis.
2001 Feb
Paradoxical increase in nitric oxide synthase activity in hypercholesterolaemic rats with impaired renal function and decreased activity of nitric oxide.
2001 Feb
Expression and characterization of recombinant rat alpha 3(IV)NC1 and its use in induction of experimental autoimmune glomerulonephritis.
2001 Feb
Impact of dialysis adequacy on the mortality and morbidity of anuric Chinese patients receiving continuous ambulatory peritoneal dialysis.
2001 Feb
Comparative effects of cerivastatin and fenofibrate on the atherogenic lipoprotein phenotype in proteinuric renal disease.
2001 Feb
Downregulation of hepatic cytochrome P450 in chronic renal failure.
2001 Feb
Protein kinase C and G(i/o) proteins are involved in adenosine- and ischemic preconditioning-mediated renal protection.
2001 Feb
Renal function and intensive lowering of blood pressure in hypertensive participants of the hypertension optimal treatment (HOT) study.
2001 Feb
Acceleration of fracture healing in nonhuman primates by fibroblast growth factor-2.
2001 Feb
Interaction of rapid nongenomic cardiovascular aldosterone effects with the adrenergic system.
2001 Feb
Reversible renal failure in paroxysmal nocturnal hemoglobinuria.
2001 Feb
Serum cystatin as a marker of glomerular filtration rate.
2001 Feb
Analysis of prognostic predictors in idiopathic membranous nephropathy.
2001 Feb
Reduced urinary excretion of intact osteopontin in patients with IgA nephropathy.
2001 Feb
Impact of donor/recipient traits independent of rejection on long-term renal function.
2001 Feb
Peritoneal transport status correlates with morbidity but not longitudinal change of nutritional status of continuous ambulatory peritoneal dialysis patients: a 2-year prospective study.
2001 Feb
Homocysteine and lipid lowering agents. A comparison between atorvastatin and fenofibrate in patients with mixed hyperlipidemia.
2001 Feb 1
Prevalence and correlates of mitral regurgitation in a population-based sample (the Strong Heart Study).
2001 Feb 1
Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients With leukemia or lymphoma.
2001 Feb 1
Functional analysis of mutations in SLC7A9, and genotype-phenotype correlation in non-Type I cystinuria.
2001 Feb 15
Predisposition to nephropathy in Polynesians is associated with family history of renal disease, not diabetes mellitus.
2001 Jan
Bone resorption is increased in young adults with thalassaemia major.
2001 Jan
Dietary supplementation with cranberry concentrate tablets may increase the risk of nephrolithiasis.
2001 Jan
In search of susceptibility genes for type 2 diabetes in West Africa: the design and results of the first phase of the AADM study.
2001 Jan
Alterations in myocardial creatinine kinase (CK) and lactate dehydrogenase (LDH) isoenzyme-distribution in a model of left ventricular dysfunction.
2001 Jan
Neurological and general outcome in low-risk coronary artery bypass patients using heparin coated circuits.
2001 Jan
Cardiovascular risk factors and the long-term outcome of lupus nephritis.
2001 Jan
Influence of nutritional factors and hemodialysis adequacy on the survival of 1,610 French patients.
2001 Jan
Survival on hemodialysis and peritoneal dialysis over 12 years with emphasis on nutritional parameters.
2001 Jan
An oral adsorbent ameliorates renal overload of indoxyl sulfate and progression of renal failure in diabetic rats.
2001 Jan
Pilot study of anti-thymocyte globulin plus mycophenolate mofetil in recent-onset diffuse scleroderma.
2001 Jan
Patents

Patents

05538991
2

Sample Use Guides

In Vivo Use Guide
Small amounts of creatinine are normally administered with food. In the study oral administration of up to 7g of creatinine does not lead to elevation of creatinine levels in the blood.
Route of Administration: Oral
In Vitro Use Guide
The blood level of creatinine is routinely measured by measurement devices. Method principles are based on a cascade of enzymatic reactions, followed by either photometric or electrochemical detection. Preferred sample types vary from whole blood to serum/plasma or both. Sample volumes range from 1 to 30 μL generally. A normal result for creatinine blood test is 0.7 to 1.3 mg/dL for men and 0.6 to 1.1 mg/dL for women.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:03:52 GMT 2023
Edited
by admin
on Fri Dec 15 15:03:52 GMT 2023
Record UNII
AYI8EX34EU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CREATININE
II   MART.   MI   USP-RS   WHO-DD  
Common Name English
CREATININE [II]
Common Name English
CREATININE [MART.]
Common Name English
2-Imino-1-methylimidazolidin-4-one
Systematic Name English
CREATININE [MI]
Common Name English
NSC-13123
Code English
KREATININUM
Common Name English
IMIDAZOLIDIN-4-ONE, 2-IMINO-1-METHYL
Common Name English
1-METHYLHYDANTOIN-2-IMIDE [INCI]
Common Name English
CREATININE [USP-RS]
Common Name English
1-METHYLHYDANTOIN-2-IMIDE
INCI  
INCI  
Official Name English
Creatinine [WHO-DD]
Common Name English
1-METHYLGLYCOCYAMIDINE
Common Name English
Classification Tree Code System Code
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Code System Code Type Description
ECHA (EC/EINECS)
200-466-7
Created by admin on Fri Dec 15 15:03:52 GMT 2023 , Edited by admin on Fri Dec 15 15:03:52 GMT 2023
PRIMARY
EVMPD
SUB33051
Created by admin on Fri Dec 15 15:03:52 GMT 2023 , Edited by admin on Fri Dec 15 15:03:52 GMT 2023
PRIMARY
WIKIPEDIA
CREATININE
Created by admin on Fri Dec 15 15:03:54 GMT 2023 , Edited by admin on Fri Dec 15 15:03:54 GMT 2023
PRIMARY
CHEMBL
CHEMBL65567
Created by admin on Fri Dec 15 15:03:52 GMT 2023 , Edited by admin on Fri Dec 15 15:03:52 GMT 2023
PRIMARY
CHEBI
16737
Created by admin on Fri Dec 15 15:03:52 GMT 2023 , Edited by admin on Fri Dec 15 15:03:52 GMT 2023
PRIMARY
FDA UNII
AYI8EX34EU
Created by admin on Fri Dec 15 15:03:52 GMT 2023 , Edited by admin on Fri Dec 15 15:03:52 GMT 2023
PRIMARY
RXCUI
2913
Created by admin on Fri Dec 15 15:03:54 GMT 2023 , Edited by admin on Fri Dec 15 15:03:54 GMT 2023
PRIMARY RxNorm
PUBCHEM
588
Created by admin on Fri Dec 15 15:03:54 GMT 2023 , Edited by admin on Fri Dec 15 15:03:54 GMT 2023
PRIMARY
RS_ITEM_NUM
1150353
Created by admin on Fri Dec 15 15:03:54 GMT 2023 , Edited by admin on Fri Dec 15 15:03:54 GMT 2023
PRIMARY
DRUG BANK
DB11846
Created by admin on Fri Dec 15 15:03:52 GMT 2023 , Edited by admin on Fri Dec 15 15:03:52 GMT 2023
PRIMARY
CAS
60-27-5
Created by admin on Fri Dec 15 15:03:52 GMT 2023 , Edited by admin on Fri Dec 15 15:03:52 GMT 2023
PRIMARY
NSC
13123
Created by admin on Fri Dec 15 15:03:54 GMT 2023 , Edited by admin on Fri Dec 15 15:03:54 GMT 2023
PRIMARY
MERCK INDEX
m3827
Created by admin on Fri Dec 15 15:03:54 GMT 2023 , Edited by admin on Fri Dec 15 15:03:54 GMT 2023
PRIMARY Merck Index
SMS_ID
100000125933
Created by admin on Fri Dec 15 15:03:54 GMT 2023 , Edited by admin on Fri Dec 15 15:03:54 GMT 2023
PRIMARY
MESH
D003404
Created by admin on Fri Dec 15 15:03:54 GMT 2023 , Edited by admin on Fri Dec 15 15:03:54 GMT 2023
PRIMARY
DAILYMED
AYI8EX34EU
Created by admin on Fri Dec 15 15:03:52 GMT 2023 , Edited by admin on Fri Dec 15 15:03:52 GMT 2023
PRIMARY
NCI_THESAURUS
C399
Created by admin on Fri Dec 15 15:03:54 GMT 2023 , Edited by admin on Fri Dec 15 15:03:54 GMT 2023
PRIMARY
EPA CompTox
DTXSID8045987
Created by admin on Fri Dec 15 15:03:52 GMT 2023 , Edited by admin on Fri Dec 15 15:03:52 GMT 2023
PRIMARY
Related Record Type Details
OCT-2
TRANSPORTER -> SUBSTRATE
OAT-2
TRANSPORTER -> SUBSTRATE
Structure of SEROTONIN CREATINE SULFATE MONOHYDRATE
SALT/SOLVATE -> PARENT
Structure of CREATININE SULFATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of PHOSPHOCREATINE
PARENT -> METABOLITE
Structure of CREATINE
PARENT -> METABOLITE
Related Record Type Details
Structure of CREATININE
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