Details
Stereochemistry | RACEMIC |
Molecular Formula | C13H19NO3 |
Molecular Weight | 237.2949 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC1=CC=CC=C1OCC2CNCCO2
InChI
InChIKey=YWPHCCPCQOJSGZ-UHFFFAOYSA-N
InChI=1S/C13H19NO3/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11/h3-6,11,14H,2,7-10H2,1H3
Molecular Formula | C13H19NO3 |
Molecular Weight | 237.2949 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Viloxazine is an antidepressant drug was used to treat patients with depression. Viloxazine inhibits noradrenaline uptake. This drug was approved in some Europe countries, but not in the USA, but then it was discontinued because of competition from other drugs. In the frame of drug repositioning, Viloxazine participated in clinical trials for the treatment of attention deficit hyperactivity disorder. Phase II of trials was successfully passed.
Approval Year
PubMed
Title | Date | PubMed |
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[Comparative evaluation of the therapeutic efficacy of the antidepressants adepren, linamiphen and emovit]. | 1986 |
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[Apropos of atypical melancholia with Sustiva (efavirenz)]. | 2001 May-Jun |
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Stereochemistry and drug efficacy and development: relevance of chirality to antidepressant and antipsychotic drugs. | 2002 |
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Clinical significance of pharmacokinetic interactions between antiepileptic and psychotropic drugs. | 2002 |
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Simultaneous determination of viloxazine, venlafaxine, imipramine, desipramine, sertraline, and amoxapine in whole blood: comparison of two extraction/cleanup procedures for capillary gas chromatography with nitrogen-phosphorus detection. | 2002 Jul-Aug |
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Intravenous antidepressant treatment: focus on citalopram. | 2002 Jun |
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Tricyclic and related drugs for nocturnal enuresis in children. | 2003 |
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A high-performance liquid chromatography method with photodiode-array UV detection for therapeutic drug monitoring of the nontricyclic antidepressant drugs. | 2003 Oct |
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Contribution of sleep research to the development of new antidepressants. | 2005 |
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The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants. | 2005 |
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Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis. | 2005 Dec 9 |
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Internet-based search of randomised trials relevant to mental health originating in the Arab world. | 2005 Jul 26 |
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Enhancing central noradrenergic function in depression: is there still a place for a new antidepressant? | 2005 Mar |
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Gastrointestinal bleeding and massive liver damage in neuroleptic malignant syndrome. | 2005 Sep |
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[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations]. | 2006 Jun |
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Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. | 2006 Oct 20 |
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Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma. | 2007 Dec 28 |
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Quantification of tricyclic antidepressants and monoamine oxidase inhibitors by high-performance liquid chromatography-tandem mass spectrometry in whole blood. | 2007 May |
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Antidepressant drugs for narcolepsy. | 2008 Jan 23 |
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Narcolepsy: current treatment options and future approaches. | 2008 Jun |
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A prognostic system applicable to patients with resectable liver metastasis from colorectal carcinoma staged by positron emission tomography with [18F]fluoro-2-deoxy-D-glucose: role of primary tumor variables. | 2008 May |
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Adjustment Disorder: epidemiology, diagnosis and treatment. | 2009 Jun 26 |
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Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry. | 2009 Nov |
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Getting the balance right: Established and emerging therapies for major depressive disorders. | 2010 Sep 7 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Oct 22 00:32:50 UTC 2019
by
admin
on
Tue Oct 22 00:32:50 UTC 2019
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Record UNII |
5I5Y2789ZF
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Record Status |
Validated (UNII)
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Record Version |
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Official Name | English | ||
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Common Name | English | ||
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WHO-ATC |
N06AX09
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WHO-VATC |
QN06AX09
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NCI_THESAURUS |
C265
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Code System | Code | Type | Description | ||
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M11448
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PRIMARY | Merck Index | ||
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3489
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DB09185
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CHEMBL306700
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VILOXAZINE
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256-281-7
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46817-91-8
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D014745
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46817-91-8
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11196
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5666
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SUB00049MIG
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C152877
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT | |||
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ENANTIOMER -> RACEMATE | |||
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ENANTIOMER -> RACEMATE |
Related Record | Type | Details | ||
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ACTIVE MOIETY |