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Details

Stereochemistry RACEMIC
Molecular Formula C13H19NO3
Molecular Weight 237.2954
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VILOXAZINE

SMILES

CCOc1ccccc1OCC2CNCCO2

InChI

InChIKey=YWPHCCPCQOJSGZ-UHFFFAOYSA-N
InChI=1S/C13H19NO3/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11/h3-6,11,14H,2,7-10H2,1H3

HIDE SMILES / InChI

Molecular Formula C13H19NO3
Molecular Weight 237.2954
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Viloxazine is an antidepressant drug was used to treat patients with depression. Viloxazine inhibits noradrenaline uptake. This drug was approved in some Europe countries, but not in the USA, but then it was discontinued because of competition from other drugs. In the frame of drug repositioning, Viloxazine participated in clinical trials for the treatment of attention deficit hyperactivity disorder. Phase II of trials was successfully passed.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: 6530
Gene ID: 6530
Gene Symbol: SLC6A2
Target Organism: Homo sapiens (Human)
Target ID: 6530
Gene ID: 6530
Gene Symbol: SLC6A2
Target Organism: Homo sapiens (Human)
PubMed

PubMed

TitleDatePubMed
[Apropos of atypical melancholia with Sustiva (efavirenz)].
2001 May-Jun
Intravenous antidepressant treatment: focus on citalopram.
2002 Jun
Enhancing central noradrenergic function in depression: is there still a place for a new antidepressant?
2005 Mar
[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].
2006 Jun
Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach.
2006 Oct 20
Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma.
2007 Dec 28
Quantification of tricyclic antidepressants and monoamine oxidase inhibitors by high-performance liquid chromatography-tandem mass spectrometry in whole blood.
2007 May
Patents

Patents

Sample Use Guides

100 mg
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Jun 25 23:08:57 UTC 2021
Edited
by admin
on Fri Jun 25 23:08:57 UTC 2021
Record UNII
5I5Y2789ZF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VILOXAZINE
INN   MI   VANDF   WHO-DD  
INN  
Official Name English
VILOXAZINE [INN]
Common Name English
VILOXAZINE [WHO-DD]
Common Name English
VILOXAZINE [MI]
Common Name English
MORPHOLINE, 2-((2-ETHOXYPHENOXY)METHYL)-
Systematic Name English
(+/-)-2-(O-ETHOXYPHENOXYMETHYL)MORPHOLINE
Common Name English
VILOXAZIN
Common Name English
VILOXAZINE [VANDF]
Common Name English
Classification Tree Code System Code
WHO-ATC N06AX09
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
WHO-VATC QN06AX09
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
NCI_THESAURUS C265
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
Code System Code Type Description
FDA UNII
5I5Y2789ZF
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
MERCK INDEX
M11448
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY Merck Index
INN
3489
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
DRUG BANK
DB09185
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
ChEMBL
CHEMBL306700
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
WIKIPEDIA
VILOXAZINE
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
ECHA (EC/EINECS)
256-281-7
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
EPA CompTox
46817-91-8
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
MESH
D014745
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
CAS
46817-91-8
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
RXCUI
11196
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY RxNorm
DRUG CENTRAL
2820
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
PUBCHEM
5666
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
EVMPD
SUB00049MIG
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
NCI_THESAURUS
C152877
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY