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Details

Stereochemistry RACEMIC
Molecular Formula C13H19NO3.ClH
Molecular Weight 273.756
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VILOXAZINE HYDROCHLORIDE

SMILES

Cl.CCOC1=C(OCC2CNCCO2)C=CC=C1

InChI

InChIKey=HJOCKFVCMLCPTP-UHFFFAOYSA-N
InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H

HIDE SMILES / InChI
Molecular Formula C13H19NO3
Molecular Weight 237.2949
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Viloxazine is an antidepressant drug was used to treat patients with depression. Viloxazine inhibits noradrenaline uptake. This drug was approved in some Europe countries, but not in the USA, but then it was discontinued because of competition from other drugs. In the frame of drug repositioning, Viloxazine participated in clinical trials for the treatment of attention deficit hyperactivity disorder. Phase II of trials was successfully passed.

Approval Year

2021
470
Targets

Targets

Primary TargetPharmacologyConditionPotency
Sodium-dependent noradrenaline transporter
38
Target ID: P23975
Gene ID: 6530.0
Gene Symbol: SLC6A2
Target Organism: Homo sapiens (Human)
Inhibitor
8297
Sodium-dependent noradrenaline transporter
38
Target ID: P23975
Gene ID: 6530.0
Gene Symbol: SLC6A2
Target Organism: Homo sapiens (Human)
Inhibitor
8297
PubMed

PubMed

TitleDatePubMed
Stereochemistry and drug efficacy and development: relevance of chirality to antidepressant and antipsychotic drugs.
2002
Simultaneous determination of viloxazine, venlafaxine, imipramine, desipramine, sertraline, and amoxapine in whole blood: comparison of two extraction/cleanup procedures for capillary gas chromatography with nitrogen-phosphorus detection.
2002 Jul-Aug
Intravenous antidepressant treatment: focus on citalopram.
2002 Jun
Tricyclic and related drugs for nocturnal enuresis in children.
2003
A high-performance liquid chromatography method with photodiode-array UV detection for therapeutic drug monitoring of the nontricyclic antidepressant drugs.
2003 Oct
The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants.
2005
Internet-based search of randomised trials relevant to mental health originating in the Arab world.
2005 Jul 26
Enhancing central noradrenergic function in depression: is there still a place for a new antidepressant?
2005 Mar
Gastrointestinal bleeding and massive liver damage in neuroleptic malignant syndrome.
2005 Sep
[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].
2006 Jun
Quantification of tricyclic antidepressants and monoamine oxidase inhibitors by high-performance liquid chromatography-tandem mass spectrometry in whole blood.
2007 May
Antidepressant drugs for narcolepsy.
2008 Jan 23
Narcolepsy: current treatment options and future approaches.
2008 Jun
A prognostic system applicable to patients with resectable liver metastasis from colorectal carcinoma staged by positron emission tomography with [18F]fluoro-2-deoxy-D-glucose: role of primary tumor variables.
2008 May
Adjustment Disorder: epidemiology, diagnosis and treatment.
2009 Jun 26
Getting the balance right: Established and emerging therapies for major depressive disorders.
2010 Sep 7
Patents

Patents

JP2006516976A
30

Sample Use Guides

In Vivo Use Guide
100 mg
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 05:26:15 UTC 2023
Edited
by admin
on Sat Dec 16 05:26:15 UTC 2023
Record UNII
OQW30I1332
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VILOXAZINE HYDROCHLORIDE
MART.   MI   USAN   WHO-DD  
USAN  
Official Name English
VILOXAZINE HYDROCHLORIDE [USAN]
Common Name English
Viloxazine hydrochloride [WHO-DD]
Common Name English
2-[(O-Ethoxyphenoxy)methyl]morpholine hydrochloride
Common Name English
SPN-812
Code English
VILOXAZINE HYDROCHLORIDE [MART.]
Common Name English
VILOXAZINE HCL
Common Name English
(±)-MORPHOLINE, 2-((2-ETHOXYPHENOXY)METHYL)-, HYDROCHLORIDE
Systematic Name English
Qelbree
Brand Name English
VIVALAN
Brand Name English
VILOXAZINE HYDROCHLORIDE [ORANGE BOOK]
Common Name English
ICI-58834
Code English
MORPHOLINE, 2-((2-ETHOXYPHENOXY)METHYL)-, HYDROCHLORIDE
Systematic Name English
ICI 58,834
Code English
VILOXAZINE HYDROCHLORIDE [MI]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 2384
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
NCI_THESAURUS C265
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
Code System Code Type Description
FDA UNII
OQW30I1332
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY
DAILYMED
OQW30I1332
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY
EVMPD
SUB05096MIG
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY
EPA CompTox
DTXSID8057722
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY
SMS_ID
100000087898
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY
RXCUI
142143
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY RxNorm
PUBCHEM
71424
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY
NCI_THESAURUS
C152878
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY
CAS
35604-67-2
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY
DRUG BANK
DBSALT001262
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY
ECHA (EC/EINECS)
252-638-6
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY
ChEMBL
CHEMBL306700
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY
MERCK INDEX
m11448
Created by admin on Sat Dec 16 05:26:15 UTC 2023 , Edited by admin on Sat Dec 16 05:26:15 UTC 2023
PRIMARY Merck Index
Related Record Type Details
Structure of VILOXAZINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of VILOXAZINE
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