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Details

Stereochemistry RACEMIC
Molecular Formula C13H19NO3.ClH
Molecular Weight 273.756
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VILOXAZINE HYDROCHLORIDE

SMILES

Cl.CCOC1=C(OCC2CNCCO2)C=CC=C1

InChI

InChIKey=HJOCKFVCMLCPTP-UHFFFAOYSA-N
InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula C13H19NO3
Molecular Weight 237.2949
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Viloxazine is an antidepressant drug was used to treat patients with depression. Viloxazine inhibits noradrenaline uptake. This drug was approved in some Europe countries, but not in the USA, but then it was discontinued because of competition from other drugs. In the frame of drug repositioning, Viloxazine participated in clinical trials for the treatment of attention deficit hyperactivity disorder. Phase II of trials was successfully passed.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P23975
Gene ID: 6530.0
Gene Symbol: SLC6A2
Target Organism: Homo sapiens (Human)
Target ID: P23975
Gene ID: 6530.0
Gene Symbol: SLC6A2
Target Organism: Homo sapiens (Human)
PubMed

PubMed

TitleDatePubMed
[Comparative evaluation of the therapeutic efficacy of the antidepressants adepren, linamiphen and emovit].
1986
Clinical significance of pharmacokinetic interactions between antiepileptic and psychotropic drugs.
2002
Intravenous antidepressant treatment: focus on citalopram.
2002 Jun
Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.
2005 Dec 9
Enhancing central noradrenergic function in depression: is there still a place for a new antidepressant?
2005 Mar
Gastrointestinal bleeding and massive liver damage in neuroleptic malignant syndrome.
2005 Sep
[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].
2006 Jun
Antidepressant drugs for narcolepsy.
2008 Jan 23
Getting the balance right: Established and emerging therapies for major depressive disorders.
2010 Sep 7
Patents

Patents

Sample Use Guides

100 mg
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Thu Jul 06 11:11:15 UTC 2023
Edited
by admin
on Thu Jul 06 11:11:15 UTC 2023
Record UNII
OQW30I1332
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VILOXAZINE HYDROCHLORIDE
MART.   MI   USAN   WHO-DD  
USAN  
Official Name English
VILOXAZINE HYDROCHLORIDE [USAN]
Common Name English
Viloxazine hydrochloride [WHO-DD]
Common Name English
2-[(O-Ethoxyphenoxy)methyl]morpholine hydrochloride
Common Name English
SPN-812
Code English
VILOXAZINE HYDROCHLORIDE [MART.]
Common Name English
VILOXAZINE HCL
Common Name English
(±)-MORPHOLINE, 2-((2-ETHOXYPHENOXY)METHYL)-, HYDROCHLORIDE
Systematic Name English
Qelbree
Brand Name English
VIVALAN
Brand Name English
VILOXAZINE HYDROCHLORIDE [ORANGE BOOK]
Common Name English
ICI-58834
Code English
MORPHOLINE, 2-((2-ETHOXYPHENOXY)METHYL)-, HYDROCHLORIDE
Systematic Name English
ICI 58,834
Code English
VILOXAZINE HYDROCHLORIDE [MI]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 2384
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
NCI_THESAURUS C265
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
Code System Code Type Description
FDA UNII
OQW30I1332
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY
DAILYMED
OQW30I1332
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY
EVMPD
SUB05096MIG
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY
EPA CompTox
DTXSID8057722
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY
SMS_ID
100000087898
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY
RXCUI
142143
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY RxNorm
PUBCHEM
71424
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY
NCI_THESAURUS
C152878
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY
CAS
35604-67-2
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY
DRUG BANK
DBSALT001262
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY
ECHA (EC/EINECS)
252-638-6
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY
ChEMBL
CHEMBL306700
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY
MERCK INDEX
M11448
Created by admin on Thu Jul 06 11:11:15 UTC 2023 , Edited by admin on Thu Jul 06 11:11:15 UTC 2023
PRIMARY Merck Index
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY