VILOXAZINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H19NO3.ClH
Molecular Weight	273.756
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCOC1=C(OCC2CNCCO2)C=CC=C1

InChI

InChIKey=HJOCKFVCMLCPTP-UHFFFAOYSA-N

InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula	C13H19NO3
Molecular Weight	237.2949
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22454923 | https://www.ncbi.nlm.nih.gov/pubmed/324751 | http://bipolarnews.org/?tag=viloxazine | https://www.ncbi.nlm.nih.gov/pubmed/30924702

Viloxazine is an antidepressant drug was used to treat patients with depression. Viloxazine inhibits noradrenaline uptake. This drug was approved in some Europe countries, but not in the USA, but then it was discontinued because of competition from other drugs. In the frame of drug repositioning, Viloxazine participated in clinical trials for the treatment of attention deficit hyperactivity disorder. Phase II of trials was successfully passed.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium-dependent noradrenaline transporter 38 Target ID: P23975 Gene ID: 6530.0 Gene Symbol: SLC6A2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/27230580	Inhibitor 8297
Sodium-dependent noradrenaline transporter 38 Target ID: P23975 Gene ID: 6530.0 Gene Symbol: SLC6A2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/27230580	Inhibitor 8297

PubMed

Title	Date	PubMed
Stereochemistry and drug efficacy and development: relevance of chirality to antidepressant and antipsychotic drugs.	2002	12553493
Enhancing central noradrenergic function in depression: is there still a place for a new antidepressant?	2005 Mar	18568121
Antidepressant drugs for narcolepsy.	2008 Jan 23	18254030

Patents

Sample Use Guides

In Vivo Use Guide

100 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:26:15 GMT 2023` Edited by `admin` on `Sat Dec 16 05:26:15 GMT 2023`
Record UNII	OQW30I1332
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

VILOXAZINE HYDROCHLORIDE

Official Name

English

VILOXAZINE HYDROCHLORIDE [USAN]

Common Name

English

Viloxazine hydrochloride [WHO-DD]

Common Name

English

2-[(O-Ethoxyphenoxy)methyl]morpholine hydrochloride

Common Name

English

SPN-812

Code

English

VILOXAZINE HYDROCHLORIDE [MART.]

Common Name

English

VILOXAZINE HCL

Common Name

English

(±)-MORPHOLINE, 2-((2-ETHOXYPHENOXY)METHYL)-, HYDROCHLORIDE

Systematic Name

English

Qelbree

Brand Name

English

VIVALAN

Brand Name

English

VILOXAZINE HYDROCHLORIDE [ORANGE BOOK]

Common Name

English

ICI-58834

Code

English

MORPHOLINE, 2-((2-ETHOXYPHENOXY)METHYL)-, HYDROCHLORIDE

Systematic Name

English

ICI 58,834

Code

English

VILOXAZINE HYDROCHLORIDE [MI]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

2384