| Stereochemistry | ABSOLUTE |
| Molecular Formula | C10H14N2 |
| Molecular Weight | 162.2316 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCC[C@H]1C2=CN=CC=C2
InChI
InChIKey=SNICXCGAKADSCV-JTQLQIEISA-N
InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
| Molecular Formula | C10H14N2 |
| Molecular Weight | 162.2316 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Nicotine is a natural alkaloid obtained from the dried leaves and stems of the nightshade family of pants, such as Nicotiana tabacum and Nicotiana rustica, where it occurs in concentrations of 0.5-8%. Cigarette tobacco varies in its nicotine content, but common blends contain 15-25 mg per cigarette, with a current trend towards lower levels. Nicotine is highly addictive substance, it exhibits a stimulant effect when adsorbed at 2 mg. Administration of higher doses could be harmful. Action of nicotine is mediated by nicotinic cholinergic receptors. Nicotine binds to the interface between two subunits of the receptors, opens the channel and allows the entry of sodium or calcium. The principal mediator of nicotine dependence is α4β2 nicotine receptor.
CNS Activity
Approval Year
Sourcing
PubMed
Patents
Sample Use Guides
Reduces withdrawal symptoms, including nicotine craving associated with quitting smoking, nicotine is available as a chewing gum, and is administered according to a schedule at doses 2-4 mg once every 2-4 hours. Nicotine is also available as a transdermal patch.
Route of Administration:
Other
Showing 1 to 5 of 23 entries
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METABOLITE LESS ACTIVE -> PARENT |
75% is converted into cotintine which is further metabolized.
MAJOR
PLASMA; URINE
RELATIONSHIP_AMOUNT
75 MOLE PERCENT OF AMOUNT ADMINISTERED (average)
[70 to 80] (limits) |
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METABOLITE -> PARENT |
circulating nicotine is metabolized to cotinine by cytochrome P450 and aldehyde oxidase
MAJOR
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METABOLITE -> PARENT |
in animals both N-oxide isomers form, in humans only the transisomers form.
MAJOR
URINE
RELATIONSHIP_AMOUNT
[4 to 7] MOLE PERCENT OF AMOUNT ADMINISTERED (limits) |
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METABOLITE -> PARENT |
The extent of nicotine N-glucuronidation by African Americans is significantly lower than by Whites.
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METABOLITE -> PARENT |
PLASMA; URINE
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Showing 1 to 5 of 7 entries
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
|
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|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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Showing 1 to 5 of 7 entries