U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C10H14N2
Molecular Weight 162.2319
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NICOTINE

SMILES

CN1CCC[C@@]1([H])c2cccnc2

InChI

InChIKey=SNICXCGAKADSCV-JTQLQIEISA-N
InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1

HIDE SMILES / InChI

Molecular Formula C10H14N2
Molecular Weight 162.2319
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Sources: www.inchem.org/documents/pims/chemical/nicotine.htm
Curator's Comment:: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928221/

Nicotine is a natural alkaloid obtained from the dried leaves and stems of the nightshade family of pants, such as Nicotiana tabacum and Nicotiana rustica, where it occurs in concentrations of 0.5-8%. Cigarette tobacco varies in its nicotine content, but common blends contain 15-25 mg per cigarette, with a current trend towards lower levels. Nicotine is highly addictive substance, it exhibits a stimulant effect when adsorbed at 2 mg. Administration of higher doses could be harmful. Action of nicotine is mediated by nicotinic cholinergic receptors. Nicotine binds to the interface between two subunits of the receptors, opens the channel and allows the entry of sodium or calcium. The principal mediator of nicotine dependence is α4β2 nicotine receptor.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
NICORETTE

Approved Use

Reduces withdrawal symptoms, including nicotine craving associated with quitting smoking

Launch Date

442713600000
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
12 ng/mL
1 mg single, nasal
dose: 1 mg
route of administration: Nasal
experiment type: SINGLE
co-administered:
NICOTINE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
6 ng × h/mL
1 mg single, nasal
dose: 1 mg
route of administration: Nasal
experiment type: SINGLE
co-administered:
NICOTINE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
3 min
1 mg single, nasal
dose: 1 mg
route of administration: Nasal
experiment type: SINGLE
co-administered:
NICOTINE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
95%
1 mg single, nasal
dose: 1 mg
route of administration: Nasal
experiment type: SINGLE
co-administered:
NICOTINE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
6 mg single, oral
Highest studied dose
Dose: 6 mg
Route: oral
Route: single
Dose: 6 mg
Sources:
healthy, 19 - 49 years
Health Status: healthy
Age Group: 19 - 49 years
Sex: M+F
Sources:
Disc. AE: Bradycardia...
AEs leading to
discontinuation/dose reduction:
Bradycardia (1 patient)
Sources:
4 mg single, oral
Studied dose
Dose: 4 mg
Route: oral
Route: single
Dose: 4 mg
Sources:
healthy, 19 - 49 years
Health Status: healthy
Age Group: 19 - 49 years
Sex: M+F
Sources:
Disc. AE: Allergic dermatitis...
AEs leading to
discontinuation/dose reduction:
Allergic dermatitis (1 patient)
Sources:
6 mg 1 times / hour steady, oral
Highest studied dose
Dose: 6 mg, 1 times / hour
Route: oral
Route: steady
Dose: 6 mg, 1 times / hour
Sources:
healthy, 19 - 50 years
Health Status: healthy
Age Group: 19 - 50 years
Sex: M+F
Sources:
Disc. AE: Hypersensitivity, Nausea...
AEs leading to
discontinuation/dose reduction:
Hypersensitivity (1 patient)
Nausea (1 patient)
Sources:
8 mg 1 times / hour steady, oral
Highest studied dose
Dose: 8 mg, 1 times / hour
Route: oral
Route: steady
Dose: 8 mg, 1 times / hour
Sources:
healthy, 19 - 50 years
Health Status: healthy
Age Group: 19 - 50 years
Sex: M+F
Sources:
Disc. AE: Depression, Nausea...
AEs leading to
discontinuation/dose reduction:
Depression (1 patient)
Nausea (grade 2-3, 2 patients)
Sources:
111 mg single, transdermal
Overdose
Dose: 111 mg
Route: transdermal
Route: single
Dose: 111 mg
Sources:
healthy, 41 years
Health Status: healthy
Age Group: 41 years
Sex: M
Sources:
Disc. AE: Death...
AEs leading to
discontinuation/dose reduction:
Death (grade 5, 1 patient)
Sources:
84 mg 1 times / day steady, transdermal
Highest studied dose
Dose: 84 mg, 1 times / day
Route: transdermal
Route: steady
Dose: 84 mg, 1 times / day
Sources:
healthy, adult
Health Status: healthy
Age Group: adult
Sex: unknown
Sources:
Other AEs: Nausea...
AEs

AEs

AESignificanceDosePopulation
Bradycardia 1 patient
Disc. AE
6 mg single, oral
Highest studied dose
Dose: 6 mg
Route: oral
Route: single
Dose: 6 mg
Sources:
healthy, 19 - 49 years
Health Status: healthy
Age Group: 19 - 49 years
Sex: M+F
Sources:
Allergic dermatitis 1 patient
Disc. AE
4 mg single, oral
Studied dose
Dose: 4 mg
Route: oral
Route: single
Dose: 4 mg
Sources:
healthy, 19 - 49 years
Health Status: healthy
Age Group: 19 - 49 years
Sex: M+F
Sources:
Hypersensitivity 1 patient
Disc. AE
6 mg 1 times / hour steady, oral
Highest studied dose
Dose: 6 mg, 1 times / hour
Route: oral
Route: steady
Dose: 6 mg, 1 times / hour
Sources:
healthy, 19 - 50 years
Health Status: healthy
Age Group: 19 - 50 years
Sex: M+F
Sources:
Nausea 1 patient
Disc. AE
6 mg 1 times / hour steady, oral
Highest studied dose
Dose: 6 mg, 1 times / hour
Route: oral
Route: steady
Dose: 6 mg, 1 times / hour
Sources:
healthy, 19 - 50 years
Health Status: healthy
Age Group: 19 - 50 years
Sex: M+F
Sources:
Depression 1 patient
Disc. AE
8 mg 1 times / hour steady, oral
Highest studied dose
Dose: 8 mg, 1 times / hour
Route: oral
Route: steady
Dose: 8 mg, 1 times / hour
Sources:
healthy, 19 - 50 years
Health Status: healthy
Age Group: 19 - 50 years
Sex: M+F
Sources:
Nausea grade 2-3, 2 patients
Disc. AE
8 mg 1 times / hour steady, oral
Highest studied dose
Dose: 8 mg, 1 times / hour
Route: oral
Route: steady
Dose: 8 mg, 1 times / hour
Sources:
healthy, 19 - 50 years
Health Status: healthy
Age Group: 19 - 50 years
Sex: M+F
Sources:
Death grade 5, 1 patient
Disc. AE
111 mg single, transdermal
Overdose
Dose: 111 mg
Route: transdermal
Route: single
Dose: 111 mg
Sources:
healthy, 41 years
Health Status: healthy
Age Group: 41 years
Sex: M
Sources:
Nausea
84 mg 1 times / day steady, transdermal
Highest studied dose
Dose: 84 mg, 1 times / day
Route: transdermal
Route: steady
Dose: 84 mg, 1 times / day
Sources:
healthy, adult
Health Status: healthy
Age Group: adult
Sex: unknown
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

Drug as perpetrator​Drug as victimTox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Cow's urine poisoning in Nigeria. Experimental observations in mice.
1975 Jun
Abstinence effects and reactivity to nicotine during 11 days of smoking deprivation.
2000 May
Involvement of 5-hydroxytryptamine(1A) receptors in nicotine-induced tail tremor in rats.
2000 Nov 10
Nicotine-induced nystagmus: three-dimensional analysis and dependence on head position.
2000 Nov 28
Kynurenic acid does not protect against nicotine-induced seizures in mice.
2000 Nov-Dec
Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior.
2000 Oct
Prenatal nicotine exposure is associated with an increase in [125I]epibatidine binding in discrete cortical regions in rats.
2000 Oct
Formation of the quaternary ammonium-linked glucuronide of nicotine in human liver microsomes: identification and stereoselectivity in the kinetics.
2001 Dec
Contributory role for nornicotine in nicotine neuropharmacology: nornicotine-evoked [3H]dopamine overflow from rat nucleus accumbens slices.
2001 Dec 15
Tolerance to nicotine's effects in the elevated plus-maze and increased anxiety during withdrawal.
2001 Feb
Nicotine induced changes in gene expression by human coronary artery endothelial cells.
2001 Feb 1
Nicotine self-administration and withdrawal: modulation of anxiety in the social interaction test in rats.
2001 Jan
Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans.
2001 Jan
Cardiovascular effects of transdermal nicotine in mildly hypertensive smokers.
2001 Jul
Nicotine produces selective degeneration in the medial habenula and fasciculus retroflexus.
2001 Jul 6
Nicotine metabolism and CYP2A6 allele frequencies in Koreans.
2001 Jun
Nicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture.
2001 Jun
Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro.
2001 Jun
Reversal of diminished inhibitory sensory gating in cocaine addicts by a nicotinic cholinergic mechanism.
2001 Jun
A novel single nucleotide polymorphism altering stability and activity of CYP2a6.
2001 Mar 2
Inhibition of nicotine-induced seizures in rats by combining vaccination against nicotine with chronic nicotine infusion.
2001 May
Smoking and balance: correlation of nicotine-induced nystagmus and postural body sway.
2001 May 8
Comparison of cytochrome P450 2A6 polymorphism frequencies in Caucasians and African-Americans using a new one-step PCR-RFLP genotyping method.
2001 Nov 30
Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system.
2001 Oct
Nicotine induced seizures blocked by mecamylamine and its stereoisomers.
2001 Oct 19
Activation of 5-HT(2C) receptors reduces the locomotor and rewarding effects of nicotine.
2001 Sep
Acute myocardial infarction soon after nicotine replacement therapy.
2001 Sep
Efficient enantiomeric synthesis of pyrrolidine and piperidine alkaloids from tobacco.
2001 Sep 21
Nornicotine, a nicotine metabolite and tobacco alkaloid: desensitization of nicotinic receptor-stimulated dopamine release from rat striatum.
2001 Sep 28
Fetal and adolescent nicotine administration: effects on CNS serotonergic systems.
2001 Sep 28
Molecular orbital calculations and nicotine metabolism: a rationale for experimentally observed metabolite ratios.
2002
Mechanisms of cytotoxicity of nicotine in human periodontal ligament fibroblast cultures in vitro.
2002 Aug
The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in withdrawal seizure-prone and withdrawal seizure-resistant selected mouse lines.
2002 Aug
Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus.
2002 Aug 27
Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior.
2002 Feb
Increased sensitivity to nicotine-induced seizures in mice heterozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor.
2002 Feb 11
An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles.
2002 Jan 11
Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures.
2002 Jan 31
Enhancement of cocaine-seeking behavior by repeated nicotine exposure in rats.
2002 Jul
Involvement of human heat shock protein 90 alpha in nicotine-induced apoptosis.
2002 Jul 1
The selectively bred high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats differ in sensitivity to nicotine.
2002 Jun
Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation.
2002 Mar
Up-regulation of L-type voltage-dependent calcium channels after long term exposure to nicotine in cerebral cortical neurons.
2002 Mar 8
Effects of whole deletion of CYP2A6 on nicotine metabolism in humans.
2002 May
beta 2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure.
2002 Oct 1
N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases.
2002 Sep
Lasting effects of adolescent nicotine exposure on the electroencephalogram, event related potentials, and locomotor activity in the rat.
2002 Sep 20
Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.
2003 Jan 1
Nicotinic acetylcholine receptors and the regulation of neuronal signalling.
2004 Jun
Nicotine addiction.
2010 Jun 17
Patents

Sample Use Guides

Reduces withdrawal symptoms, including nicotine craving associated with quitting smoking, nicotine is available as a chewing gum, and is administered according to a schedule at doses 2-4 mg once every 2-4 hours. Nicotine is also available as a transdermal patch.
Route of Administration: Other
Functional activity of nicotine against hα4β2 nicotinic receptors was evaluated using the 86Rb+ ion flux assay in SH-EP1 cells, expressing hα4β2. The 86Rb+ efflux was measured using the “flip-plate” technique. Nicotine activated 86Rb+ efflux with EC50 of 290 nM.
Substance Class Chemical
Created
by admin
on Fri Jun 25 20:58:06 UTC 2021
Edited
by admin
on Fri Jun 25 20:58:06 UTC 2021
Record UNII
6M3C89ZY6R
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
NICOTINE
EP   HSDB   ISO   MART.   MI   ORANGE BOOK   USP   VANDF   WHO-DD  
Systematic Name English
NICOTINE [HSDB]
Common Name English
NSC-5065
Code English
NICODERM CQ
Brand Name English
NICOTINE [ISO]
Common Name English
NICOTINE [MI]
Common Name English
PYRIDINE, 3-((2S)-1-METHYL-2-PYRROLIDINYL)-
Systematic Name English
NICOTINE [VANDF]
Common Name English
PROSTEP
Brand Name English
3-((2S)-1-METHYLPYRROLIDIN-2-YL)PYRIDINE
Systematic Name English
3-((2S)-1-METHYL-2-PYRROLIDINYL)PYRIDINE
Systematic Name English
HABITROL
Brand Name English
NICOTINUM
HPUS  
Common Name English
NICOTINE COMPONENT OF COMMIT
Brand Name English
NICOTINE [EP MONOGRAPH]
Common Name English
NICOTINE [USP MONOGRAPH]
Common Name English
NICOTINE [WHO-DD]
Common Name English
NICOTINUM [HPUS]
Common Name English
NICOTINE [ORANGE BOOK]
Common Name English
NICOTINE COMPONENT OF NICORETTE
Brand Name English
.BETA.-PYRIDYL-.ALPHA.-N-METHYL PYRROLIDINE
Common Name English
NICOTINE S(-)
Common Name English
NICOTROL
Brand Name English
NICOTINE [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C221
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
LIVERTOX 683
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
WHO-ATC N07BA01
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
NDF-RT N0000175706
Created by admin on Fri Jun 25 20:58:07 UTC 2021 , Edited by admin on Fri Jun 25 20:58:07 UTC 2021
WHO-VATC QP53AX13
Created by admin on Fri Jun 25 20:58:07 UTC 2021 , Edited by admin on Fri Jun 25 20:58:07 UTC 2021
WHO-VATC QN07BA01
Created by admin on Fri Jun 25 20:58:07 UTC 2021 , Edited by admin on Fri Jun 25 20:58:07 UTC 2021
EPA PESTICIDE CODE 56702
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
NDF-RT N0000006496
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
NCI_THESAURUS C73579
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
NDF-RT N0000006496
Created by admin on Fri Jun 25 20:58:07 UTC 2021 , Edited by admin on Fri Jun 25 20:58:07 UTC 2021
Code System Code Type Description
MESH
D009538
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
RXCUI
7407
Created by admin on Fri Jun 25 20:58:07 UTC 2021 , Edited by admin on Fri Jun 25 20:58:07 UTC 2021
PRIMARY
IUPHAR
2585
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
NCI_THESAURUS
C691
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
PUBCHEM
89594
Created by admin on Fri Jun 25 20:58:07 UTC 2021 , Edited by admin on Fri Jun 25 20:58:07 UTC 2021
PRIMARY
HSDB
1107
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
WIKIPEDIA
NICOTINE
Created by admin on Fri Jun 25 20:58:07 UTC 2021 , Edited by admin on Fri Jun 25 20:58:07 UTC 2021
PRIMARY
ChEMBL
CHEMBL3
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
DRUG BANK
DB00184
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
EPA CompTox
54-11-5
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
EVMPD
SUB14645MIG
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
LACTMED
Nicotine
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
CAS
54-11-5
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
EVMPD
SUB30160
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
DRUG CENTRAL
1920
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
MERCK INDEX
M7879
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY Merck Index
FDA UNII
6M3C89ZY6R
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-193-3
Created by admin on Fri Jun 25 20:58:06 UTC 2021 , Edited by admin on Fri Jun 25 20:58:06 UTC 2021
PRIMARY
Related Record Type Details
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
TARGET -> AGONIST
NICOTINE IS AN ANTIHERBIVORY ALKALOID AND POTENT PARASYMPATHOMIMETIC STIMULANT AND FOUND IN PLANTS, MOSTLY THOSE IN THE NIGHTSHADE FAMILY. NICOTINE ACTS AS A RECEPTOR AGONIST AT MOST NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS), EXCEPT AT TWO NICOTINIC RECEPTOR SUBUNITS (NACHR.ALPHA.9 AND NACHR.ALPHA.10) WHERE IT ACTS AS A RECEPTOR ANTAGONIST.
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
USP
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
BINDER->LIGAND
BINDING
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
SUB_CONCEPT->SUBSTANCE
SALT/SOLVATE -> PARENT
PARENT -> CONSTITUENT ALWAYS PRESENT
Nicotine (mg/cigarette) Domestic = 12.6 SD(1.6) Imported = 11.1 SD(2.2)
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
METABOLIC ENZYME -> SUBSTRATE
SALT/SOLVATE -> PARENT
LABELED -> NON-LABELED
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
METABOLITE LESS ACTIVE -> PARENT
75% is converted into cotintine which is further metabolized.
MAJOR
PLASMA; URINE
METABOLITE -> PARENT
circulating nicotine is metabolized to cotinine by cytochrome P450 and aldehyde oxidase
MAJOR
METABOLITE -> PARENT
in animals both N-oxide isomers form, in humans only the transisomers form.
MAJOR
URINE
METABOLITE -> PARENT
The extent of nicotine N-glucuronidation by African Americans is significantly lower than by Whites.
METABOLITE -> PARENT
PLASMA; URINE
METABOLITE -> PARENT
The extent of Cotinine N-glucuronidation by African Americans is significantly lower than by Whites.
METABOLITE INACTIVE -> PARENT
Related Record Type Details
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC