U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C24H29NO3
Molecular Weight 379.4929
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DONEPEZIL

SMILES

COc1cc2CC(CC3CCN(CC3)Cc4ccccc4)C(=O)c2cc1OC

InChI

InChIKey=ADEBPBSSDYVVLD-UHFFFAOYSA-N
InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C24H29NO3
Molecular Weight 379.4929
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Donepezil, marketed under the trade name Aricept, is a medication used in the palliative treatment of Alzheimer's disease. Aricept is indicated for the treatment of dementia of the Alzheimer’s type. Efficacy has been demonstrated in patients with mild to moderate Alzheimer’s Disease, as well as in patients with severe Alzheimer’s Disease. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. Donepezil has been tested in other cognitive disorders including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, and Down syndrome.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
ARICEPT

Approved Use

Donepezil hydrochloride orally disintegrating tablets, USP are an acetylcholinesterase inhibitor indicated for the treatment of dementia of the Alzheimer's type. Efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer's Disease (1). Donepezil hydrochloride orally disintegrating tablets, USP are indicated for the treatment of dementia of the Alzheimer's type. Efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer's disease.

Launch Date

8.4888001E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
34.1 ng/mL
5 mg 1 times / day steady-state, oral
dose: 5 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
DONEPEZIL blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
60.5 ng/mL
10 mg 1 times / day steady-state, oral
dose: 10 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
DONEPEZIL blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
2889.3 ng × h/mL
5 mg 1 times / day steady-state, oral
dose: 5 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
DONEPEZIL blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
5051.9 ng × h/mL
10 mg 1 times / day steady-state, oral
dose: 10 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
DONEPEZIL blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
72.7 h
5 mg 1 times / day steady-state, oral
dose: 5 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
DONEPEZIL blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
73.5 h
10 mg 1 times / day steady-state, oral
dose: 10 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
DONEPEZIL blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
4.4%
5 mg 1 times / day steady-state, oral
dose: 5 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
DONEPEZIL blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
4.4%
10 mg 1 times / day steady-state, oral
dose: 10 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
DONEPEZIL blood
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
175 mg single, transdermal
Dose: 175 mg
Route: transdermal
Route: single
Dose: 175 mg
Sources:
healthy, 24.9±3.3 years
n = 9
Health Status: healthy
Age Group: 24.9±3.3 years
Sex: M
Population Size: 9
Sources:
175 mg 1 times / 3 days steady, transdermal
Dose: 175 mg, 1 times / 3 days
Route: transdermal
Route: steady
Dose: 175 mg, 1 times / 3 days
Sources:
healthy, 24.9±3.3 years
n = 9
Health Status: healthy
Age Group: 24.9±3.3 years
Sex: M
Population Size: 9
Sources:
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Disc. AE: Bradycardia, Diarrhea...
AEs leading to
discontinuation/dose reduction:
Bradycardia (0.7%)
Diarrhea (1.7%)
Nausea (1.9%)
Vomiting (2.9%)
QT interval prolonged (0.4%)
Anorexia (0.3%)
Dizziness (1.1%)
Headache (0.4%)
Somnolence (0.6%)
Syncope (0.2%)
Aggression (0.5%)
Agitation (0.8%)
Confusional state (0.7%)
Sources: Page: p. 50
50 mg single, oral
Overdose
Dose: 50 mg
Route: oral
Route: single
Dose: 50 mg
Sources:
unhealthy, 79 years
n = 1
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 79 years
Sex: F
Population Size: 1
Sources:
Other AEs: Nausea, Vomiting...
Other AEs:
Nausea (1 patient)
Vomiting (1 patient)
Bradycardia (1 patient)
Sources:
30 mg 1 times / day steady, oral
Dose: 30 mg, 1 times / day
Route: oral
Route: steady
Dose: 30 mg, 1 times / day
Sources:
unhealthy, 80 years
n = 1
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 80 years
Sex: F
Population Size: 1
Sources:
Disc. AE: Myoclonus...
AEs leading to
discontinuation/dose reduction:
Myoclonus (1 patient)
Sources:
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
n = 315
Health Status: unhealthy
Age Group: adult
Population Size: 315
Sources:
Other AEs: Diarrhea, Nausea...
Other AEs:
Diarrhea (3%)
Nausea (3%)
Vomiting (2%)
Sources:
5 mg 1 times / day steady, oral
Recommended
Dose: 5 mg, 1 times / day
Route: oral
Route: steady
Dose: 5 mg, 1 times / day
Sources:
unhealthy, adult
n = 350
Health Status: unhealthy
Age Group: adult
Population Size: 350
Sources:
Disc. AE: Diarrhea...
AEs leading to
discontinuation/dose reduction:
Diarrhea (<1%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Syncope 0.2%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Anorexia 0.3%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Headache 0.4%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
QT interval prolonged 0.4%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Aggression 0.5%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Somnolence 0.6%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Bradycardia 0.7%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Confusional state 0.7%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Agitation 0.8%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Dizziness 1.1%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Diarrhea 1.7%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Nausea 1.9%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Vomiting 2.9%
Disc. AE
23 mg 1 times / day steady, oral
Dose: 23 mg, 1 times / day
Route: oral
Route: steady
Dose: 23 mg, 1 times / day
Sources: Page: p. 50
unhealthy, 73.9 years
n = 967
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 73.9 years
Sex: M+F
Population Size: 967
Sources: Page: p. 50
Bradycardia 1 patient
50 mg single, oral
Overdose
Dose: 50 mg
Route: oral
Route: single
Dose: 50 mg
Sources:
unhealthy, 79 years
n = 1
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 79 years
Sex: F
Population Size: 1
Sources:
Nausea 1 patient
50 mg single, oral
Overdose
Dose: 50 mg
Route: oral
Route: single
Dose: 50 mg
Sources:
unhealthy, 79 years
n = 1
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 79 years
Sex: F
Population Size: 1
Sources:
Vomiting 1 patient
50 mg single, oral
Overdose
Dose: 50 mg
Route: oral
Route: single
Dose: 50 mg
Sources:
unhealthy, 79 years
n = 1
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 79 years
Sex: F
Population Size: 1
Sources:
Myoclonus 1 patient
Disc. AE
30 mg 1 times / day steady, oral
Dose: 30 mg, 1 times / day
Route: oral
Route: steady
Dose: 30 mg, 1 times / day
Sources:
unhealthy, 80 years
n = 1
Health Status: unhealthy
Condition: Alzheimer disease
Age Group: 80 years
Sex: F
Population Size: 1
Sources:
Vomiting 2%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
n = 315
Health Status: unhealthy
Age Group: adult
Population Size: 315
Sources:
Diarrhea 3%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
n = 315
Health Status: unhealthy
Age Group: adult
Population Size: 315
Sources:
Nausea 3%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
n = 315
Health Status: unhealthy
Age Group: adult
Population Size: 315
Sources:
Diarrhea <1%
Disc. AE
5 mg 1 times / day steady, oral
Recommended
Dose: 5 mg, 1 times / day
Route: oral
Route: steady
Dose: 5 mg, 1 times / day
Sources:
unhealthy, adult
n = 350
Health Status: unhealthy
Age Group: adult
Population Size: 350
Sources:
PubMed

PubMed

TitleDatePubMed
Selective inhibitors of butyrylcholinesterase: a valid alternative for therapy of Alzheimer's disease?
2001
The beneficial effect of cholinesterase inhibitors on patients suffering from Parkinson's disease and dementia.
2001
EEG changes during long-term treatment with donepezil in Alzheimer's disease patients.
2001
Galantamine for Alzheimer's disease.
2001
Maintaining functional and behavioral abilities in Alzheimer disease.
2001 Aug
Maintaining cognitive function in Alzheimer disease: how effective are current treatments?
2001 Aug
Prevalence, costs, and treatment of Alzheimer's disease and related dementia: a managed care perspective.
2001 Aug
A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD.
2001 Aug 14
A 1-year, placebo-controlled preservation of function survival study of donepezil in AD patients.
2001 Aug 14
Randomized placebo-controlled trial of donepezil in patients with progressive supranuclear palsy.
2001 Aug 14
Galantamine: new preparation. The fourth cholinesterase inhibitor for Alzheimer's disease.
2001 Dec
Unsafe prescription medication switching recommendations.
2001 Dec
Donepezil in schizophrenia--is it helpful? An experimental design case study.
2001 Dec
Alzheimer's disease: recent advances in etiology, diagnosis, and management.
2001 Dec
[Alzheimer dementia. Comparison of the effectiveness of cholinesterase inhibitors and gingko].
2001 Dec 13
[A patient with probable dementia with Lewy bodies, who showed improvement of dementia and parkinsonism by the administratim of donepezil].
2001 Jul
Pisa syndrome due to a cholinesterase inhibitor (donepezil): a case report.
2001 Jul
[Aphasia and dementia].
2001 Jul
An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients.
2001 Jul-Sep
Actigraphic sleep-wake patterns and urinary 6-sulfatoxymelatonin excretion in patients with Alzheimer's disease.
2001 May
Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat.
2001 Nov
[Malignant syndrome caused by a combination of bromperidol and donepezil hydrochloride in a patient with probable dementia with Lewy bodies].
2001 Nov
Cerebrospinal fluid acetylcholinesterase activity after long-term treatment with donepezil and rivastigmina.
2001 Nov
Platelet amyloid precursor protein forms in AD: a peripheral diagnostic tool and a pharmacological target.
2001 Nov
Equity in the new NHS. Evidence cannot help in all situations.
2001 Nov 10
[A comparison of cholinesterase inhibitors and ginkgo extract in treatment of Alzheimer dementia].
2001 Nov 29
Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.
2001 Nov 8
[Risperidone in the ambulatory treatment of behavior disorders in demented patients of Alzheimer's type: a retrospective analysis].
2001 Nov-Dec
A case of Korsakoff's syndrome improved by high doses of donepezil.
2001 Nov-Dec
Treatment of tardive dyskinesia with donepezil: a pilot study.
2001 Oct
[Effectiveness of donepezil on several cognitive functions in patients with Alzheimer's disease over 12 months].
2001 Oct
Donepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease.
2001 Oct
[Relief for caregivers. Anti-dementia drug saves costs].
2001 Oct 18
[Anticholinesterase agents in Alzheimer's disease].
2001 Sep
Economic evaluation of donepezil treatment for Alzheimer's disease in Japan.
2002
Donepezil management of schizophrenia with associated dementia.
2002 Apr
Donepezil in the treatment of Alzheimer's disease: long-term efficacy and safety.
2002 Feb
Feasibility of vascular dementia treatment with cholinesterase inhibitors.
2002 Feb
Atrophy of the substantia innominata on magnetic resonance imaging and response to donepezil treatment in Alzheimer's disease.
2002 Feb 8
[Pharmacotherapy for the treatment of Alzheimer's disease--the present state and the development in the future].
2002 Jan
A new HPLC method to determine Donepezil hydrochloride in tablets.
2002 Jan 1
[Alzheimer dementia. Intervening as early as possible].
2002 Jan 17
Therapeutic effects of an acetylcholinesterase inhibitor (donepezil) on memory in Wernicke-Korsakoff's disease.
2002 Jan-Feb
A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease--pilot study.
2002 Mar
Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients.
2002 Mar
A double blind placebo controlled trial of donepezil adjunctive treatment to risperidone for the cognitive impairment of schizophrenia.
2002 Mar 1
A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD.
2002 Mar 12
Determination of donepezil, an acetylcholinesterase inhibitor, in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection.
2002 Mar 5
In vitro toxicity of rivastigmine and donepezil in cells of epithelial origin.
2002 Mar-Apr
Donepezil improved the clinical state and quality of life in moderate-to-severe Alzheimer disease.
2002 Mar-Apr
Patents

Sample Use Guides

Mild to Moderate Alzheimer’s Disease - 5 mg or 10 mg administered once daily Moderate to Severe Alzheim er’s Disease - 10 mg or 23 mg administered once daily A dose of 10 mg once daily can be administered once patients have been on a daily dose of 5 mg for 4 to 6 weeks. A dose of 23 mg once daily can be administered once patien ts have been on a dose of 10 mg once daily for at least 3 months
Route of Administration: Oral
Donepezil inhibited freshly prepared human erythrocyte AChE with IC50 22 nM
Substance Class Chemical
Created
by admin
on Sat Jun 26 16:36:59 UTC 2021
Edited
by admin
on Sat Jun 26 16:36:59 UTC 2021
Record UNII
8SSC91326P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DONEPEZIL
HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
DONEPEZIL [WHO-DD]
Common Name English
D-797
Common Name English
1-BENZYL-4-((5,6-DIMETHOXY-1-INDANON-2-YL)METHYL)PIPERIDINE
Systematic Name English
DONAZ
Brand Name English
5,6-DIMETHOXY-2-((1-(PHENYLMETHYL)-4-PIPERIDINYL)METHYL)-2,3-DIHYDRO-1H-INDEN-1-ONE
Systematic Name English
DONEPEZIL [INN]
Common Name English
(+/-)-2-((1-BENZYL-4-PIPERIDYL)METHYL)-5,6-DIMETHOXY-1-INDANONE
Systematic Name English
1H-INDEN-1-ONE, 2,3-DIHYDRO-5,6-DIMETHOXY-2-((1-(PHENYLMETHYL)-4-PIPERIDINYL)METHYL)-
Systematic Name English
DONEPEZIL [HSDB]
Common Name English
DONEPEZIL [VANDF]
Common Name English
2,3-DIHYDRO-5,6-DIMETHOXY-2-((1-(PHENYLMETHYL)-4-PIPERIDINYL)METHYL)-1H-INDEN-1-ONE
Systematic Name English
D797
Common Name English
DONEPEZIL [MI]
Common Name English
Classification Tree Code System Code
NDF-RT N0000175723
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
WHO-VATC QN06DA02
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
NDF-RT N0000000177
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
WHO-VATC QN06DA52
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
WHO-ATC N06DA52
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
LIVERTOX 323
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
WHO-ATC N06DA53
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
WHO-ATC N06DA02
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
NCI_THESAURUS C47792
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
Code System Code Type Description
RXCUI
135447
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY RxNorm
CAS
120014-06-4
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
FDA UNII
8SSC91326P
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
WIKIPEDIA
DONEPEZIL
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
MESH
C076946
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
MERCK INDEX
M4738
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY Merck Index
INN
7517
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
DRUG CENTRAL
946
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
DRUG BANK
DB00843
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
IUPHAR
6599
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
HSDB
7743
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
ChEMBL
CHEMBL502
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
EVMPD
SUB06362MIG
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
NCI_THESAURUS
C66874
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
EPA CompTox
120014-06-4
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
PUBCHEM
3152
Created by admin on Sat Jun 26 16:37:00 UTC 2021 , Edited by admin on Sat Jun 26 16:37:00 UTC 2021
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
TARGET -> INHIBITOR
METABOLIC ENZYME -> SUBSTRATE
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ACTIVE MOIETY