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Details

Stereochemistry ABSOLUTE
Molecular Formula C17H24F2N6O
Molecular Weight 366.4095
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GOSOGLIPTIN

SMILES

c1cnc(nc1)N2CCN(CC2)[C@@]3([H])C[C@@]([H])(C(=O)N4CCC(C4)(F)F)NC3

InChI

InChIKey=QWEWGXUTRTXFRF-KBPBESRZSA-N
InChI=1S/C17H24F2N6O/c18-17(19)2-5-25(12-17)15(26)14-10-13(11-22-14)23-6-8-24(9-7-23)16-20-3-1-4-21-16/h1,3-4,13-14,22H,2,5-12H2/t13-,14-/m0/s1

HIDE SMILES / InChI

Molecular Formula C17H24F2N6O
Molecular Weight 366.4095
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Gosogliptin (PF-734200) is a compound developed for treatment of type II diabetes and has been approved for use in Russia. It is a selective dipeptidyl peptidase 4 (DPP-4) inhibitor, with hypoglycemic activity. The drug is safe and well tolerated at all doses tested when added to metformin (a diabetes drug), and safely and effectively lowered HbA (1c) in subjects receiving metformin. A phase 3 study to study the safety and efficacy of gosogliptin has been completed. Gosogliptin has also been studied as potential drug for the treatment of renal insufficiency.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
13.0 nM [IC50]
PubMed

PubMed

TitleDatePubMed
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.
2009 Apr 1
The pharmacokinetics of PF-734200, a DPP-IV inhibitor, in subjects with renal insufficiency.
2011 Jul
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 04:34:58 UTC 2021
Edited
by admin
on Sat Jun 26 04:34:58 UTC 2021
Record UNII
GI718UO477
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GOSOGLIPTIN
INN   USAN  
USAN   INN  
Official Name English
(3,3-DIFLUOROPYRROLIDIN-1-YL)((2S,4S)-4-(4-(PYRIMIDIN-2-YL)PIPERAZIN-1-YL)PYRROLIDIN-2-YL)METHANONE
Systematic Name English
PF-734200
Code English
GOSOGLIPTIN [INN]
Common Name English
GOSOGLIPTIN [USAN]
Common Name English
METHANONE, (3,3-DIFLUORO-1-PYRROLIDINYL)((2S,4S)-4-(4-(2-PYRIMIDINYL)-1-PIPERAZINYL)-2-PYRROLIDINYL)-
Systematic Name English
PF-734,200
Code English
PF-00734200
Code English
GOSOGLIPTIN [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C98086
Created by admin on Sat Jun 26 04:34:59 UTC 2021 , Edited by admin on Sat Jun 26 04:34:59 UTC 2021
Code System Code Type Description
FDA UNII
GI718UO477
Created by admin on Sat Jun 26 04:34:59 UTC 2021 , Edited by admin on Sat Jun 26 04:34:59 UTC 2021
PRIMARY
INN
9148
Created by admin on Sat Jun 26 04:34:59 UTC 2021 , Edited by admin on Sat Jun 26 04:34:59 UTC 2021
PRIMARY
CAS
869490-23-3
Created by admin on Sat Jun 26 04:34:59 UTC 2021 , Edited by admin on Sat Jun 26 04:34:59 UTC 2021
PRIMARY
ChEMBL
CHEMBL515387
Created by admin on Sat Jun 26 04:34:59 UTC 2021 , Edited by admin on Sat Jun 26 04:34:59 UTC 2021
PRIMARY
PUBCHEM
11516136
Created by admin on Sat Jun 26 04:34:59 UTC 2021 , Edited by admin on Sat Jun 26 04:34:59 UTC 2021
PRIMARY
DRUG BANK
DB08382
Created by admin on Sat Jun 26 04:34:59 UTC 2021 , Edited by admin on Sat Jun 26 04:34:59 UTC 2021
PRIMARY
NCI_THESAURUS
C90616
Created by admin on Sat Jun 26 04:34:59 UTC 2021 , Edited by admin on Sat Jun 26 04:34:59 UTC 2021
PRIMARY
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Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC SINGLE DOSE

ORAL ADMINISTRATION

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Biological Half-life PHARMACOKINETIC IN HEALTHY MALE VOLUNTEERS

SINGLE DOSE

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