Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C19H23NO3 |
Molecular Weight | 313.3915 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOc1ccc2C[C@]3([H])[C@]4([H])C=C[C@@]([H])([C@@]5([H])[C@]4(CCN3C)c2c1O5)O
InChI
InChIKey=OGDVEMNWJVYAJL-LEPYJNQMSA-N
InChI=1S/C19H23NO3/c1-3-22-15-7-4-11-10-13-12-5-6-14(21)18-19(12,8-9-20(13)2)16(11)17(15)23-18/h4-7,12-14,18,21H,3,8-10H2,1-2H3/t12-,13+,14-,18-,19-/m0/s1
Molecular Formula | C19H23NO3 |
Molecular Weight | 313.3915 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
CNS Activity
Approval Year
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1.09 μM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7654478 |
1.5 mg/kg bw single, oral dose: 1.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
ETHYLMORPHINE serum | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
222 μM × min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7654478 |
1.5 mg/kg bw single, oral dose: 1.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
ETHYLMORPHINE serum | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1.97 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7654478 |
1.5 mg/kg bw single, oral dose: 1.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
ETHYLMORPHINE serum | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
Doses
Dose | Population | Adverse events |
---|---|---|
8.5 mg single, oral |
healthy, 10 months n = 1 Health Status: healthy Age Group: 10 months Sex: M Population Size: 1 Sources: |
Other AEs: Sedation... |
1.5 mg/kg single, oral Dose: 1.5 mg/kg Route: oral Route: single Dose: 1.5 mg/kg Sources: |
healthy, 24 years n = 10 Health Status: healthy Age Group: 24 years Sex: M Population Size: 10 Sources: |
Other AEs: Dizziness, Drowsiness... Other AEs: Dizziness (7 patients) Sources: Drowsiness (slight, 2 patients) Loose stools (1 patient) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Sedation | grade 5 | 8.5 mg single, oral |
healthy, 10 months n = 1 Health Status: healthy Age Group: 10 months Sex: M Population Size: 1 Sources: |
Loose stools | 1 patient | 1.5 mg/kg single, oral Dose: 1.5 mg/kg Route: oral Route: single Dose: 1.5 mg/kg Sources: |
healthy, 24 years n = 10 Health Status: healthy Age Group: 24 years Sex: M Population Size: 10 Sources: |
Dizziness | 7 patients | 1.5 mg/kg single, oral Dose: 1.5 mg/kg Route: oral Route: single Dose: 1.5 mg/kg Sources: |
healthy, 24 years n = 10 Health Status: healthy Age Group: 24 years Sex: M Population Size: 10 Sources: |
Drowsiness | slight, 2 patients | 1.5 mg/kg single, oral Dose: 1.5 mg/kg Route: oral Route: single Dose: 1.5 mg/kg Sources: |
healthy, 24 years n = 10 Health Status: healthy Age Group: 24 years Sex: M Population Size: 10 Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
Simultaneous determination of codeine and ethyl morphine HCL in tablet formulations using LC. | 2001 Aug |
|
Screening for drugs of abuse in hair with ion spray LC-MS-MS. | 2004 Oct 29 |
|
Inhibition of rat liver CYP2D in vitro and after 1-day and long-term exposure to neuroleptics in vivo-possible involvement of different mechanisms. | 2005 Jan |
|
Automated multiple development thin-layer chromatography for separation of opiate alkaloids and derivatives. | 2005 Jul 8 |
|
Validation of direct injection electrospray LC-MS/MS for confirmation of opiates in urine drug testing. | 2007 Jul |
|
Purification of CYP2B-like protein from feral leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular, and immunological characterization. | 2008 Jul-Aug |
|
Determining plasma morphine levels using GC-MS after solid phase extraction to monitor drug levels in the postoperative period. | 2008 Jun |
|
Driving under the influence of opiates: concentration relationships between morphine, codeine, 6-acetyl morphine, and ethyl morphine in blood. | 2008 May |
|
Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography-tandem mass spectrometry. | 2009 Apr 15 |
|
Determination of opiates and cocaine in urine by high pH mobile phase reversed phase UPLC-MS/MS. | 2009 Feb 1 |
|
[Pharmacological treatment of acute cough]. | 2009 May 14 |
|
Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats. | 2010 Mar |
|
Bovine liver slices combined with an androgen transcriptional activation assay: an in-vitro model to study the metabolism and bioactivity of steroids. | 2010 May |
Sample Use Guides
The recommended dose in adults is 50 mg of codethyline per day, i.e. 10 tablets (1 tablet contains 5 mg of ethylmorphine hydrochloride) per day over several intakes, at a minimum of 4 hours apart. In children the normal dose is 1 tablet per intake, to be renewed after 6 hours if necessary, without exceeding 4 tablets per day.
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 06:45:46 UTC 2021
by
admin
on
Sat Jun 26 06:45:46 UTC 2021
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Record UNII |
RWO67D87EU
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Record Status |
Validated (UNII)
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Record Version |
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Code | English | ||
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Systematic Name | English |
Classification Tree | Code System | Code | ||
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WHO-VATC |
QS01XA06
Created by
admin on Sat Jun 26 06:45:46 UTC 2021 , Edited by admin on Sat Jun 26 06:45:46 UTC 2021
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DEA NO. |
9190
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NCI_THESAURUS |
C67413
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WHO-ATC |
S01XA06
Created by
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WHO-VATC |
QR05DA01
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WHO-ATC |
R05DA01
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Code System | Code | Type | Description | ||
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3207
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PRIMARY | |||
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D005036
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PRIMARY | |||
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4166
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PRIMARY | RxNorm | ||
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5359271
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PRIMARY | |||
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200-970-7
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PRIMARY | |||
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DB01466
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PRIMARY | |||
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RWO67D87EU
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PRIMARY | |||
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76-58-4
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PRIMARY | |||
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CHEMBL1712170
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PRIMARY | |||
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ETHYLMORPHINE
Created by
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PRIMARY | |||
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76-58-4
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PRIMARY | |||
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C83704
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PRIMARY | |||
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M5154
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PRIMARY | Merck Index | ||
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SUB13765MIG
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PRIMARY |
Related Record | Type | Details | ||
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METABOLIC ENZYME -> SUBSTRATE | |||
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SALT/SOLVATE -> PARENT |
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
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SALT/SOLVATE -> PARENT |
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
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Related Record | Type | Details | ||
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ACTIVE MOIETY |