Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H27FN4O2 |
| Molecular Weight | 397.4763 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN(CC)C(=O)CC1=C2N=C(C)C=C(C)N2N=C1C3=CC=C(OCC[18F])C=C3
InChI
InChIKey=FLZZFWBNYJNHMY-VNRZBHCFSA-N
InChI=1S/C22H27FN4O2/c1-5-26(6-2)20(28)14-19-21(17-7-9-18(10-8-17)29-12-11-23)25-27-16(4)13-15(3)24-22(19)27/h7-10,13H,5-6,11-12,14H2,1-4H3/i23-1
| Molecular Formula | C22H27FN4O2 |
| Molecular Weight | 397.4763 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
BAY85-8102 (widely known as (18)F-DPA-714) is a specific radioligand for the translocator protein (TSPO). TSPO, formerly known as the peripheral benzodiazepine receptor, is dramatically upregulated under pathologic conditions. BAY85-8102 in combination with positron emission tomography imaging participated in phase I clinical trials for investigation of neuroinflammation in Alzheimer's patients. However, this study was terminated early. Clinical pharmacology/efficacy parameters planned in the protocol were not evaluated at the end of the study
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. | 2008 May |
|
| Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO). | 2010 Oct 1 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:15:29 GMT 2023
by
admin
on
Sat Dec 16 10:15:29 GMT 2023
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| Record UNII |
0VMV8Z3972
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| Record Status |
Validated (UNII)
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| Record Version |
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23582365
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0VMV8Z3972
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958233-09-5
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300000042435
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| Related Record | Type | Details | ||
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METABOLIC ENZYME -> SUBSTRATE |
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TARGET->RADIOLIGAND |
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METABOLIC ENZYME -> SUBSTRATE |
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ACTIVE MOIETY |
Substance Name: 18F-DPA-714, RN: 958233-09-5; Registry Numbers: (1)CAS Registry Number: 958233-09-5, (2)System Generated Number: 0958233095
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