U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C6H8O7
Molecular Weight 192.1238
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ANHYDROUS CITRIC ACID

SMILES

C(C(=O)O)C(CC(=O)O)(C(=O)O)O

InChI

InChIKey=KRKNYBCHXYNGOX-UHFFFAOYSA-N
InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

HIDE SMILES / InChI

Molecular Formula C6H8O7
Molecular Weight 192.1238
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: http://www.adm.com/en-US/worldwide/australia/Documents/Potassium%20Citrate%20AU.pdf | https://noshly.com/additive/e332/acidity-regulator-plus/332/#.WUp-1uvyjIU

Potassium citrate is indicated for the management of renal tubular acidosis with calcium stones, hypocitraturic calcium oxalate nephrolithiasis of any etiology, uric acid lithiasis with or without calcium stones. WhenPotassium citrate is given orally, the metabolism of absorbed citrate produces an alkaline load. The induced alkaline load in turn increases urinary pH and raises urinary citrate by augmenting citrate clearance without measurably altering ultrafilterable serum citrate. Thus, potassium citrate therapy appears to increase urinary citrate principally by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. Potassium citrate is used as a food additive (E 332) to regulate acidity.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
UROCIT-K

Approved Use

Urocit®-K is a citrate salt of potassium indicated for the management of: • Renal tubular acidosis (RTA) with calcium stones • Hypocitraturic calcium oxalate nephrolithiasis of any etiology • Uric acid lithiasis with or without calcium stones

Launch Date

494121600000
Primary
UROCIT-K

Approved Use

Urocit®-K is a citrate salt of potassium indicated for the management of: • Renal tubular acidosis (RTA) with calcium stones • Hypocitraturic calcium oxalate nephrolithiasis of any etiology • Uric acid lithiasis with or without calcium stones

Launch Date

494121600000
Doses

Doses

DosePopulationAdverse events​
540 mg 1 times / day multiple, oral
Recommended
dose: 540 mg 1 times / day
route: oral
experiment_type: multiple
dose_type: Recommended
co-adm with
    data_source:
    https://pubmed.ncbi.nlm.nih.gov/14646190
    healthy, 24-59
    population: healthy
    age: 24-59
    sex: M+F
    food_status:
    n:
    data_source:
    https://pubmed.ncbi.nlm.nih.gov/14646190
    Sourcing

    Sourcing

    Vendor/AggregatorIDURL
    PubMed

    PubMed

    TitleDatePubMed
    Comparative efficacy of "specific" potassium citrate therapy versus conservative management in nephrolithiasis of mild to moderate severity.
    1985 Oct
    Renal hypouricemia due to enhanced tubular secretion of urate associated with urolithiasis: successful treatment of urolithiasis by alkalization of urine K+, Na(+)-citrate.
    1993
    [Therapeutic use of potassium citrate].
    2001
    Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.
    2013 Jun
    Patents

    Sample Use Guides

    In Vivo Use Guide
    Objective: To restore normal urinary citrate (greater than 320 mg/day and as close to the normal mean of 640 mg/day as possible), and to increase urinary
    Route of Administration: Oral
    Substance Class Chemical
    Created
    by admin
    on Sat Jun 26 09:26:54 UTC 2021
    Edited
    by admin
    on Sat Jun 26 09:26:54 UTC 2021
    Record UNII
    XF417D3PSL
    Record Status Validated (UNII)
    Record Version
    • Download
    Name Type Language
    ANHYDROUS CITRIC ACID
    II   MART.  
    Common Name English
    CITRIC ACID (CONSTITUENT OF CRANBERRY LIQUID PREPARATION) [DSC]
    Common Name English
    FEMA NO. 2306
    Code English
    CITRIC ACID (CONSTITUENT OF GARCINIA CAMBOGIA AND GARCINIA INDICA) [DSC]
    Common Name English
    ANHYDROUS CITRIC ACID [MART.]
    Common Name English
    CITRIC ACID MONOGLYCERIDE
    Common Name English
    ANHYDROUS CITRIC ACID [JAN]
    Common Name English
    2-HYDROXY-1,2,3-PROPANETRICARBOXYIC ACID
    Systematic Name English
    ANHYDROUS CITRIC ACID [USP MONOGRAPH]
    Common Name English
    ACIDUM CITRICUM [WHO-IP LATIN]
    Common Name English
    CITRIC ACID,ANHYDROUS
    VANDF  
    Common Name English
    CITRIC ACID, ANHYDROUS
    EP   USP   WHO-IP  
    Common Name English
    CITRIC ACID ANHYDROUS
    JAN  
    Common Name English
    CITRIC ACID, ANHYDROUS [EP]
    Common Name English
    CLENPIQ COMPONENT ANHYDROUS CITRIC ACID
    Brand Name English
    ACILETTEN
    Common Name English
    1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-
    Common Name English
    ANHYDROUS CITRIC ACID [II]
    Common Name English
    NSC-112226
    Code English
    NSC-626579
    Code English
    CITRIC ACID, ANHYDROUS [USP]
    Common Name English
    3-CARBOXY-3-HYDROXYPENTANE-1,5-DIOIC ACID
    Systematic Name English
    CITRICUM ACIDUM
    HPUS  
    Common Name English
    CITRIC ACID [WHO-DD]
    Common Name English
    ANHYDROUS CITRIC ACID COMPONENT OF CLENPIQ
    Brand Name English
    CITRIC ACID,ANHYDROUS [VANDF]
    Common Name English
    CITRIC ACID [HSDB]
    Common Name English
    CITRIC ACID [MI]
    Common Name English
    CITRIC ACID, ANHYDROUS [WHO-IP]
    Common Name English
    CITRICUM ACIDUM [HPUS]
    Common Name English
    NSC-30279
    Code English
    CITRIC ACID [FHFI]
    Common Name English
    Classification Tree Code System Code
    NDF-RT N0000175980
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    NDF-RT N0000175835
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    NCI_THESAURUS C275
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    NDF-RT N0000175833
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    Code System Code Type Description
    RXCUI
    221946
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    PRIMARY RxNorm
    CAS
    77-92-9
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    PRIMARY
    NDF-RT
    N0000008556
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    PRIMARY Decreased Coagulation Factor Activity [PE]
    ECHA (EC/EINECS)
    201-069-1
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    PRIMARY
    MERCK INDEX
    M3595
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    PRIMARY Merck Index
    FDA UNII
    XF417D3PSL
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    PRIMARY
    NCI_THESAURUS
    C80088
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    PRIMARY
    PUBCHEM
    311
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    PRIMARY
    EVMPD
    SUB29050
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    PRIMARY
    DRUG CENTRAL
    4473
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    PRIMARY
    WHO INTERNATIONAL PHARMACOPEIA
    ANHYDROUS CITRIC ACID
    Created by admin on Sat Jun 26 09:27:01 UTC 2021 , Edited by admin on Sat Jun 26 09:27:01 UTC 2021
    PRIMARY Description: Colourless crystals or a white, crystalline powder; odourless or practically odourless.Solubility: Very soluble in water; freely soluble in ethanol (~750 g/l) TS; sparingly soluble in ether R.Category: Acidifying agent; buffer component.Storage: Citric acid should be kept in a well-closed container.Labelling: The designation on the container of Citric acid should state whether it is the monohydrate or the anhydrous form.Additional information. Citric acid monohydrate effloresces in dry air.
    Related Record Type Details
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    PARENT -> CONSTITUENT ALWAYS PRESENT
    USP
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    PARENT -> CONSTITUENT ALWAYS PRESENT
    USP
    SALT/SOLVATE -> PARENT
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    Related Record Type Details
    PARENT -> METABOLITE INACTIVE
    Unit: percent of dose; Amount combined with "Fumaric Acid"
    IN-VIVO
    PLASMA
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    IMPURITY -> PARENT
    ASSAY (COLORIMETRIC)
    USP
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    ACTIVE MOIETY