Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H8O7 |
| Molecular Weight | 192.1235 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CC(O)(CC(O)=O)C(O)=O
InChI
InChIKey=KRKNYBCHXYNGOX-UHFFFAOYSA-N
InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
| Molecular Formula | C6H8O7 |
| Molecular Weight | 192.1235 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including
http://www.adm.com/en-US/worldwide/australia/Documents/Potassium%20Citrate%20AU.pdf | https://noshly.com/additive/e332/acidity-regulator-plus/332/#.WUp-1uvyjIU
Curator's Comment: Description was created based on several sources, including
http://www.adm.com/en-US/worldwide/australia/Documents/Potassium%20Citrate%20AU.pdf | https://noshly.com/additive/e332/acidity-regulator-plus/332/#.WUp-1uvyjIU
Potassium citrate is indicated for the management of renal tubular acidosis with calcium stones, hypocitraturic calcium oxalate nephrolithiasis of any etiology, uric acid lithiasis with or without calcium stones. WhenPotassium citrate is given orally, the metabolism of absorbed citrate produces an alkaline load. The induced alkaline load in turn increases urinary pH and raises urinary citrate by augmenting citrate clearance without measurably altering ultrafilterable serum citrate. Thus, potassium citrate therapy appears to increase urinary citrate principally by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. Potassium citrate is used as a food additive (E 332) to regulate acidity.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: GO:0010447 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | UROCIT-K Approved UseUrocit®-K is a citrate salt of potassium indicated for the management of:
• Renal tubular acidosis (RTA) with calcium stones
• Hypocitraturic calcium oxalate nephrolithiasis of any etiology
• Uric acid lithiasis with or without calcium stones Launch Date1985 |
|||
| Primary | UROCIT-K Approved UseUrocit®-K is a citrate salt of potassium indicated for the management of:
• Renal tubular acidosis (RTA) with calcium stones
• Hypocitraturic calcium oxalate nephrolithiasis of any etiology
• Uric acid lithiasis with or without calcium stones Launch Date1985 |
Doses
| Dose | Population | Adverse events |
|---|---|---|
540 mg 1 times / day multiple, oral Recommended Dose: 540 mg, 1 times / day Route: oral Route: multiple Dose: 540 mg, 1 times / day Co-administed with:: Thiamin oral 1.1 mg Sources: Page: p.2326Arginine oral 1240 mg caffeine oral 52 mg |
healthy, 24-59 n = 16 Health Status: healthy Age Group: 24-59 Sex: M+F Population Size: 16 Sources: Page: p.2326 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Comparative efficacy of "specific" potassium citrate therapy versus conservative management in nephrolithiasis of mild to moderate severity. | 1985 Oct |
|
| Renal hypouricemia due to enhanced tubular secretion of urate associated with urolithiasis: successful treatment of urolithiasis by alkalization of urine K+, Na(+)-citrate. | 1993 |
|
| [Therapeutic use of potassium citrate]. | 2001 |
|
| Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity. | 2013 Jun |
Sample Use Guides
Objective: To restore normal urinary citrate (greater than 320 mg/day and as close to the normal mean of 640 mg/day as possible), and to increase urinary
pH to a level of 6.0 to 7.0.
• Severe hypocitraturia (urinary citrate < 150 mg/day): therapy should be initiated at 60 mEq per day; a dose of 30 mEq two times per day or 20 mEq three times per day with meals or within 30 minutes after meals or bedtime snack
• Mild to moderate hypocitraturia (urinary citrate >150 mg/day): therapy should be initiated at 30 mEq per day; a dose of 15 mEq two times per day or 10 mEq three times per day with meals or within 30 minutes after meals or bedtime snack
Route of Administration:
Oral
| Substance Class |
Chemical
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C275
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NDF-RT |
N0000175833
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221946
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77-92-9
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N0000008556
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m3595
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112226
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C80088
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4473
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ANHYDROUS CITRIC ACID
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PRIMARY | Description: Colourless crystals or a white, crystalline powder; odourless or practically odourless.Solubility: Very soluble in water; freely soluble in ethanol (~750 g/l) TS; sparingly soluble in ether R.Category: Acidifying agent; buffer component.Storage: Citric acid should be kept in a well-closed container.Labelling: The designation on the container of Citric acid should state whether it is the monohydrate or the anhydrous form.Additional information. Citric acid monohydrate effloresces in dry air. |
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PARENT -> METABOLITE INACTIVE |
Unit: percent of dose; Amount combined with "Fumaric Acid"
IN-VIVO
PLASMA
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IMPURITY -> PARENT |
ASSAY (COLORIMETRIC)
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ACTIVE MOIETY |
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