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Details

Stereochemistry ACHIRAL
Molecular Formula C14H23N3S2.C6H8O7
Molecular Weight 489.609
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TAZOMELINE CITRATE

SMILES

CCCCCCSc1c(C2=CCCN(C)C2)nsn1.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

InChI

InChIKey=WIOWZFAHNWMORW-UHFFFAOYSA-N
InChI=1S/C14H23N3S2.C6H8O7/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h8H,3-7,9-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

HIDE SMILES / InChI

Molecular Formula C14H23N3S2
Molecular Weight 297.4852
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H8O7
Molecular Weight 192.1238
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Tazomeline (also known as LY 287041), a neuropsychiatric agent, is a muscarinic M1 acetylcholine receptor agonist that was studied in patients with cognitive dysfunction. Tazomeline participated in clinical trials for the treatment of Alzheimer’s disease and dementia. However, all these studied were discontinued for unknown reasons.

Approval Year

PubMed

PubMed

TitleDatePubMed
Muscarinic acetylcholine receptors as CNS drug targets.
2008 Feb
Substance Class Chemical
Created
by admin
on Sat Jun 26 00:53:05 UTC 2021
Edited
by admin
on Sat Jun 26 00:53:05 UTC 2021
Record UNII
O494QX2F4D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TAZOMELINE CITRATE
USAN  
USAN  
Official Name English
LY287041
Code English
TAZOMELINE CITRATE [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47796
Created by admin on Sat Jun 26 00:53:06 UTC 2021 , Edited by admin on Sat Jun 26 00:53:06 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C66581
Created by admin on Sat Jun 26 00:53:06 UTC 2021 , Edited by admin on Sat Jun 26 00:53:06 UTC 2021
PRIMARY
CAS
175615-45-9
Created by admin on Sat Jun 26 00:53:06 UTC 2021 , Edited by admin on Sat Jun 26 00:53:06 UTC 2021
PRIMARY
PUBCHEM
23209321
Created by admin on Sat Jun 26 00:53:06 UTC 2021 , Edited by admin on Sat Jun 26 00:53:06 UTC 2021
PRIMARY
FDA UNII
O494QX2F4D
Created by admin on Sat Jun 26 00:53:06 UTC 2021 , Edited by admin on Sat Jun 26 00:53:06 UTC 2021
PRIMARY
ChEMBL
CHEMBL131819
Created by admin on Sat Jun 26 00:53:06 UTC 2021 , Edited by admin on Sat Jun 26 00:53:06 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY