TAZOMELINE CITRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H23N3S2.C6H8O7
Molecular Weight	489.606
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCCCCSC1=NSN=C1C2=CCCN(C)C2

InChI

InChIKey=WIOWZFAHNWMORW-UHFFFAOYSA-N

InChI=1S/C14H23N3S2.C6H8O7/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h8H,3-7,9-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

HIDE SMILES / InChI

Molecular Formula	C14H23N3S2
Molecular Weight	297.483
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H8O7
Molecular Weight	192.1235
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18082893 | https://adisinsight.springer.com/drugs/800003441 | https://www.genome.jp/dbget-bin/www_bget?dr:D06015

Tazomeline (also known as LY 287041), a neuropsychiatric agent, is a muscarinic M1 acetylcholine receptor agonist that was studied in patients with cognitive dysfunction. Tazomeline participated in clinical trials for the treatment of Alzheimer’s disease and dementia. However, all these studied were discontinued for unknown reasons.

Originator

Approval Year

PubMed

Title	Date	PubMed
Muscarinic acetylcholine receptors as CNS drug targets.	2008 Feb	18082893

Substance Class	Chemical Created by `admin` on `Fri Dec 16 20:26:54 UTC 2022` Edited by `admin` on `Fri Dec 16 20:26:54 UTC 2022`
Record UNII	O494QX2F4D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TAZOMELINE CITRATE

Official Name

English

LY287041

Code

English

TAZOMELINE CITRATE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47796