TAZOMELINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H23N3S2
Molecular Weight	297.483
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCSC1=NSN=C1C2=CCCN(C)C2

InChI

InChIKey=XUHMGFKQBWZWPO-UHFFFAOYSA-N

InChI=1S/C14H23N3S2/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C14H23N3S2
Molecular Weight	297.483
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18082893 | https://adisinsight.springer.com/drugs/800003441 | https://www.genome.jp/dbget-bin/www_bget?dr:D06015

Tazomeline (also known as LY 287041), a neuropsychiatric agent, is a muscarinic M1 acetylcholine receptor agonist that was studied in patients with cognitive dysfunction. Tazomeline participated in clinical trials for the treatment of Alzheimer’s disease and dementia. However, all these studied were discontinued for unknown reasons.

Originator

Approval Year

PubMed

Title	Date	PubMed
Muscarinic acetylcholine receptors as CNS drug targets.	2008 Feb	18082893

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:17:22 UTC 2023` Edited by `admin` on `Fri Dec 15 17:17:22 UTC 2023`
Record UNII	QDP6S14W5W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TAZOMELINE

Official Name

English

LY-287041

Code

English

3-(4-(HEXYLTHIO)-1,2,5-THIADIAZOL-3-YL)-1,2,5,6-TETRAHYDRO-1-METHYLPYRIDINE

Systematic Name

English

PYRIDINE, 3-(4-(HEXYLTHIO)-1,2,5-THIADIAZOL-3-YL)-1,2,5,6-TETRAHYDRO-1-METHYL-

Systematic Name

English

tazomeline [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47796