U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C6H8O7.H2O
Molecular Weight 210.1388
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CITRIC ACID MONOHYDRATE

SMILES

O.OC(=O)CC(O)(CC(O)=O)C(O)=O

InChI

InChIKey=YASYEJJMZJALEJ-UHFFFAOYSA-N
InChI=1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

HIDE SMILES / InChI

Molecular Formula C6H8O7
Molecular Weight 192.1235
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.adm.com/en-US/worldwide/australia/Documents/Potassium%20Citrate%20AU.pdf | https://noshly.com/additive/e332/acidity-regulator-plus/332/#.WUp-1uvyjIU

Potassium citrate is indicated for the management of renal tubular acidosis with calcium stones, hypocitraturic calcium oxalate nephrolithiasis of any etiology, uric acid lithiasis with or without calcium stones. WhenPotassium citrate is given orally, the metabolism of absorbed citrate produces an alkaline load. The induced alkaline load in turn increases urinary pH and raises urinary citrate by augmenting citrate clearance without measurably altering ultrafilterable serum citrate. Thus, potassium citrate therapy appears to increase urinary citrate principally by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. Potassium citrate is used as a food additive (E 332) to regulate acidity.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
UROCIT-K

Approved Use

Urocit®-K is a citrate salt of potassium indicated for the management of: • Renal tubular acidosis (RTA) with calcium stones • Hypocitraturic calcium oxalate nephrolithiasis of any etiology • Uric acid lithiasis with or without calcium stones

Launch Date

4.94121615E11
Primary
UROCIT-K

Approved Use

Urocit®-K is a citrate salt of potassium indicated for the management of: • Renal tubular acidosis (RTA) with calcium stones • Hypocitraturic calcium oxalate nephrolithiasis of any etiology • Uric acid lithiasis with or without calcium stones

Launch Date

4.94121615E11
Doses

Doses

DosePopulationAdverse events​
540 mg 1 times / day multiple, oral
Recommended
Dose: 540 mg, 1 times / day
Route: oral
Route: multiple
Dose: 540 mg, 1 times / day
Co-administed with::
Thiamin oral 1.1 mg
Arginine oral 1240 mg
caffeine oral 52 mg
Sources: Page: p.2326
healthy, 24-59
n = 16
Health Status: healthy
Age Group: 24-59
Sex: M+F
Population Size: 16
Sources: Page: p.2326
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Renal hypouricemia due to enhanced tubular secretion of urate associated with urolithiasis: successful treatment of urolithiasis by alkalization of urine K+, Na(+)-citrate.
1993
Patents

Sample Use Guides

In Vivo Use Guide
Objective: To restore normal urinary citrate (greater than 320 mg/day and as close to the normal mean of 640 mg/day as possible), and to increase urinary pH to a level of 6.0 to 7.0. • Severe hypocitraturia (urinary citrate < 150 mg/day): therapy should be initiated at 60 mEq per day; a dose of 30 mEq two times per day or 20 mEq three times per day with meals or within 30 minutes after meals or bedtime snack • Mild to moderate hypocitraturia (urinary citrate >150 mg/day): therapy should be initiated at 30 mEq per day; a dose of 15 mEq two times per day or 10 mEq three times per day with meals or within 30 minutes after meals or bedtime snack
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:04:53 UTC 2023
Edited
by admin
on Fri Dec 15 15:04:53 UTC 2023
Record UNII
2968PHW8QP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CITRIC ACID MONOHYDRATE
EP   II   MART.   MI   USP   VANDF   WHO-DD   WHO-IP  
Systematic Name English
CITRIC ACID MONOHYDRATE [EP IMPURITY]
Common Name English
E-330
Code English
CITRIC ACID [ORANGE BOOK]
Common Name English
TAUROLOCK COMPONENT CITRATE
Common Name English
2-HYDROXY-1,2,3-PROPANE-TRICARBOXYLIC ACID, MONOHYDRATE
Common Name English
CITRIC ACID MONOHYDRATE [WHO-IP]
Common Name English
CITRIC ACID MONOHYDRATE [MART.]
Common Name English
CITRIC ACID [VANDF]
Common Name English
INS-330
Code English
CITRIC ACID COMPONENT OF RENACIDIN
Common Name English
CITRIC ACID, HYDROUS [II]
Common Name English
B1650 [LANGUAL]
Common Name English
Citric acid monohydrate [WHO-DD]
Common Name English
CITRIC ACID COMPONENT OF IDKIT:HP
Common Name English
CITRIC ACID, HYDROUS
II  
Common Name English
CITRIC ACID [II]
Common Name English
CITRIC ACID MONOHYDRATE [VANDF]
Common Name English
2-HYDROXY-1,2,3-PROPANE-TRICARBOXYLIC ACID
Systematic Name English
CITRIC ACID,HYDROUS [VANDF]
Common Name English
CITRIC ACID MONOHYDRATE [USP MONOGRAPH]
Common Name English
CITRIC ACID [EP MONOGRAPH]
Common Name English
CITRIC ACID HYDRATE [JAN]
Common Name English
ACIDUM CITRICUM MONOHYDRATE [WHO-IP LATIN]
Common Name English
CITRIC ACID
GREEN BOOK   II   INCI   ORANGE BOOK   VANDF  
INCI  
Official Name English
CITRATE [VANDF]
Common Name English
CITRIC ACID,HYDROUS
VANDF  
Common Name English
CITRIC ACID BP
Common Name English
CITRATE
II   VANDF  
Systematic Name English
CITRIC ACID MONOHYDRATE [EP MONOGRAPH]
Common Name English
1,2,3-PROPANETRICARBOXYLIC ACID, 2 HYDROXY-, MONOHYDRATE
Common Name English
CITRIC ACID MONOHYDRATE [MI]
Common Name English
CITRATE [II]
Common Name English
INS NO.330
Code English
CITRIC ACID [INCI]
Common Name English
CITRIC ACID MONOHYDRATE [II]
Common Name English
CITRIC ACID [GREEN BOOK]
Common Name English
Classification Tree Code System Code
LOINC 41022-5
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 44306-9
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 13722-4
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
WHO-ATC A09AB04
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 10567-6
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
EU-Orphan Drug EU/3/16/1675
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 27133-8
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
FDA ORPHAN DRUG 583217
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
NCI_THESAURUS C275
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 57339-4
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
FDA ORPHAN DRUG 9785
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
FDA ORPHAN DRUG 731120
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 2126-1
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 15038-3
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 2128-7
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 2127-9
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 6687-8
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
DSLD 1461 (Number of products:5)
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
DSLD 1653 (Number of products:141)
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 51792-0
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 21203-5
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 14650-6
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
NCI_THESAURUS C345
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 57338-6
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 29527-9
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 34266-7
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 57337-8
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
LOINC 25876-4
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
Code System Code Type Description
CFR
21 CFR 184.1033
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
DRUG BANK
DB04272
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
EVMPD
SUB22082
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
JECFA EVALUATION
CITRIC ACID
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
ChEMBL
CHEMBL1261
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
LACTMED
Cellulose and Citric Acid
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
JECFA EVALUATION
INS-330
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
CODEX ALIMENTARIUS (GSFA)
INS-330
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
RXCUI
221079
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
CHEBI
133748
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
EPA PESTICIDE CODE
21801
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
NON-SPECIFIC SUBSTITUTION
SMS_ID
100000137641
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
WHO-VATC
QA09AB04
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
CHEBI
50744
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
EPA CompTox
DTXSID7074668
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
CFR
21 CFR 331.11
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
MERCK INDEX
m3595
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY Merck Index
CHEBI
16947
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
RXCUI
114200
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
ALTERNATIVE
WHO INTERNATIONAL PHARMACOPEIA
CITRIC ACID MONOHYDRATE
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY Description: Colourless crystals or a white, crystalline powder; odourless or practically odourless.Solubility: Very soluble in water; freely soluble in ethanol (~750 g/l) TS; sparingly soluble in ether R.Category: Acidifying agent; buffer component.Storage: Citric acid should be kept in a well-closed container.Labelling: The designation on the container of Citric acid should state whether it is the monohydrate or the anhydrous form.Additional information. Citric acid monohydrate effloresces in dry air.
MESH
D019343
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
EVMPD
SUB12639MIG
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
PUBCHEM
22230
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
DRUG CENTRAL
666
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
DAILYMED
2968PHW8QP
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
LACTMED
Lactic Acid, Citric Acid, and Potassium Bitartrate
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
WIKIPEDIA
CITRIC ACID
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
EVMPD
SUB76183
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
NCI_THESAURUS
C47452
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
FDA UNII
2968PHW8QP
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
CFR
21 CFR 331.15
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
RXCUI
21183
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
ALTERNATIVE
CHEBI
30769
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
RS_ITEM_NUM
1134368
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
EVMPD
SUB29131
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
CAS
5949-29-1
Created by admin on Fri Dec 15 15:04:53 UTC 2023 , Edited by admin on Fri Dec 15 15:04:53 UTC 2023
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE
Related Record Type Details
ACTIVE MOIETY