FERROUS CITRATE

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H6O7.Fe
Molecular Weight	245.953
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C(C(=O)[O-])C(CC(=O)[O-])(C(=O)O)O.[Fe+2]

InChI

InChIKey=APVZWAOKZPNDNR-UHFFFAOYSA-L

InChI=1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+2/p-2

HIDE SMILES / InChI

Molecular Formula	Fe
Molecular Weight	55.8451
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H6O7
Molecular Weight	190.1079
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.foodchemadditives.com/products/Ferrous-Lactatehttp://www.drugfuture.com/chemdata/ferroglycine-sulfate.htmlhttps://www.ncbi.nlm.nih.gov/pubmed/16694502http://www.druglead.com/cds/ferrous-iodide.htmlhttps://www.drugs.com/inactive/ferrous-oxide-389.htmlDOI: 10.1021/ja00949a016 Retrived from http://pubs.acs.org/doi/abs/10.1021/ja00949a016http://nj.gov/health/eoh/rtkweb/documents/fs/0928.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/14116934
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/672678 | https://www.ncbi.nlm.nih.gov/pubmed/27138526 | https://www.ncbi.nlm.nih.gov/pubmed/20685224 | https://www.ncbi.nlm.nih.gov/pubmed/26911730

FERROUS ASPARTATE is an iron supplement used to treat or prevent low blood levels of iron. Iron is an important mineral that the body needs to produce red blood cells and keep you in good health.

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2502
Anemia 69 Sources: http://www.medicatione.com/?c=ing&s=ferrous%20aspartate	Palliative	Not Provided 492	Unknown Approved Use Unknown
Unknown 2502
Hypochromic anemia 37 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16694502	Palliative	Not Provided 492	Unknown Approved Use Unknown
Unknown 2502
Unknown 2502
Unknown 2502
Iron deficiency 79 Sources: http://www.minapharm.com/Public/ProductDetails.aspx?ProductCode=FERRO_SANO&langParam=en	Primary	Approved 8043	Ferro Sanol Duodenal Approved Use Ferro Sanol is an iron substitute in case of latent or manifest iron deficiency with and without development of anaemia.
Radioactive cesium and/or radioactive or non-radioactive thallium internal contamination 37 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/021626lbl.pdf	Curative	Approved 8043	RADIOGARDASE Approved Use Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination. Launch Date 1.06496642E12
Unknown 2502

PubMed

Title	Date	PubMed
FERROUS IODIDE AS A SUBSTITUTE FOR VITAMIN A IN RATS.	1932 Jul 1	17815234
FERROUS IODIDE AND LINOLEIC ACID IN VITAMIN A DEFICIENCY. A REPLY TO CERTAIN CRITICISMS.	1932 Nov 11	17744342
THE ADMINISTRATION OF FERROUS IODIDE AND LINOLEIC ACID TO RATS DEPRIVED OF VITAMIN A.	1932 Sep 30	17754111
THE USE OF FERROUS GLUCONATE IN THE TREATMENT OF HYPOCHROMIC ANEMIA.	1937 Jul	16694502
[Ferrous lactate as an oral iron preparation for therapeutic use].	1954 Nov 27	14348915
Clinical appraisal of drugs with special reference to a new chelate hematinic.	1957 Jul 11	13452048
[FERROUS ASPARTATE IN THERAPY].	1964 Jan 1	14116934
[Historical notes on the therapy of depression].	1986 Nov 22	3541174
Determination of water in ferrous lactate by near infrared reflectance spectroscopy with a fibre-optic probe.	1997 Oct	9408841
Decreased treatment failure rates following duodenal release ferrous glycine sulfate in iron deficiency anemia associated with autoimmune gastritis and Helicobacter pylori gastritis.	2007	17426393
Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice.	2009	19421372
Bioleaching of heavy metals from sewage sludge by indigenous iron-oxidizing microorganisms using ammonium ferrous sulfate and ferrous sulfate as energy sources: a comparative study.	2009 Nov 15	19586718
The effect of iron treatment on adhesion molecules in patients with iron deficiency anemia.	2010 Dec	20039148
Endothelial dysfunction and inflammation induced by iron oxide nanoparticle exposure: Risk factors for early atherosclerosis.	2011 Jun 10	21439359
Tolerability of different oral iron supplements: a systematic review.	2013 Apr	23252877
Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows.	2013 Jul	23660146
A practical and successful desensitization protocol for immediate hypersensitivity reactions to iron salts.	2014	25402762
Synthesis of phosphabenzenes by an iron-catalyzed [2+2+2] cycloaddition reaction of diynes with phosphaalkynes.	2015 Jun 22	25981197
Reactivity enhancement of iron sulfide nanoparticles stabilized by sodium alginate: Taking Cr (VI) removal as an example.	2017 Jul 5	28371713
Atomic Layer Deposition of Iron Sulfide and Its Application as a Catalyst in the Hydrogenation of Azobenzenes.	2017 Mar 13	28170144
Continuous sulfidogenic wastewater treatment with iron sulfide sludge oxidation and recycle.	2017 May 1	28249212

Patents

Sample Use Guides

In Vivo Use Guide

as food additives

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Jun 26 16:14:54 UTC 2021` Edited by `admin` on `Sat Jun 26 16:14:54 UTC 2021`
Record UNII	33KM3X4QQW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FERROUS CITRATE

Common Name

English

IRON(II) CITRATE

Systematic Name

English

FERROUS CITRATE [MI]

Common Name

English

FERROUS CITRATE [HSDB]

Common Name

English

CITRIC ACID, IRON(2+) SALT

Common Name

English

FERROUS CITRATE [WHO-DD]

Common Name

English

FERROUS CITRATE [FCC]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 184.1307C