U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2C6H5O7.3Fe
Molecular Weight 555.0045
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERROUS CITRATE FE-59

SMILES

C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Fe+2].[Fe+2].[Fe+2]

InChI

InChIKey=PFKAKHILNWLJRT-ZHVHGXCCSA-H
InChI=1S/2C6H8O7.3Fe/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6/i;;3*1+3

HIDE SMILES / InChI

Molecular Formula Fe
Molecular Weight 58.9349
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H5O7
Molecular Weight 189.1
Charge -3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/2330802 | https://www.ncbi.nlm.nih.gov/pubmed/5098207

Ferrous citrate Fe 59 is indicated, by intravenous administration, to determine various parameters of the kinetics of iron metabolism, including plasma iron clearance, plasma iron turnover rate, and the utilization of iron in new red blood cells. The values of serum iron obtained from these studies provide diagnostic information in patients with anemias. Ferrous citrate Fe 59 is also useful to assess the role of the spleen in red blood cell production and destruction, and thus to help determine the advisability of splenectomy. Also, organ uptake measurements are used to measure the sites of red cell production (or lack thereof) in extramedullary erythropoiesis in myeloproliferative disorders. Iron from ferrous citrate is bound to plasma protein (transferrin) and carried to the blood-forming organs where it is utilized to form hemoglobin or is deposited in the reticuloendothelial cells of the liver and spleen. The amount of radioactive iron absorbed, transported, stored, utilized, and excreted can then be measured by the periodic collection of blood specimens and external counting.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
FERROUS CITRATE FE 59

Approved Use

It was used for anemia diagnosis.

Launch Date

1.24847997E11
Diagnostic
FERROUS CITRATE FE 59

Approved Use

Unknown

Launch Date

1.24934398E11
PubMed

PubMed

TitleDatePubMed
Effect of anticholinergic agents on the intestinal absorption of 59 Fe ferrous citrate.
1971 Sep
Patents

Patents

Sample Use Guides

Intravenous or oral, 0.185 to 0.555 megabecquerel (5 to 15 microcuries).
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 05:58:43 UTC 2021
Edited
by admin
on Sat Jun 26 05:58:43 UTC 2021
Record UNII
PW94HT3KE9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERROUS CITRATE FE-59
Common Name English
IRON(II) CITRATE FE 59
Common Name English
FERROUS CITRATE FE 59 [USAN]
Common Name English
FERROUS CITRATE,FE-59 [VANDF]
Common Name English
IRON(2+)-(SUP 59)FE CITRATE
Common Name English
FERROUS CITRATE FE 59
USAN  
USAN  
Official Name English
FERROUS CITRATE,FE-59
VANDF  
Common Name English
FERROUS CITRATE, FE-59 [ORANGE BOOK]
Common Name English
FERROUS CITRATE FE59
Common Name English
FERROUS CITRATE, FE-59
ORANGE BOOK  
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1446
Created by admin on Sat Jun 26 05:58:43 UTC 2021 , Edited by admin on Sat Jun 26 05:58:43 UTC 2021
Code System Code Type Description
PUBCHEM
11353432
Created by admin on Sat Jun 26 05:58:43 UTC 2021 , Edited by admin on Sat Jun 26 05:58:43 UTC 2021
PRIMARY
ChEMBL
CHEMBL2110914
Created by admin on Sat Jun 26 05:58:43 UTC 2021 , Edited by admin on Sat Jun 26 05:58:43 UTC 2021
PRIMARY
CAS
22205-04-5
Created by admin on Sat Jun 26 05:58:43 UTC 2021 , Edited by admin on Sat Jun 26 05:58:43 UTC 2021
PRIMARY
FDA UNII
PW94HT3KE9
Created by admin on Sat Jun 26 05:58:43 UTC 2021 , Edited by admin on Sat Jun 26 05:58:43 UTC 2021
PRIMARY
NCI_THESAURUS
C76278
Created by admin on Sat Jun 26 05:58:43 UTC 2021 , Edited by admin on Sat Jun 26 05:58:43 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY