Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H20ClN3.C6H8O7 |
| Molecular Weight | 529.969 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CC(O)(CC(O)=O)C(O)=O.ClC1=CC=C(C=C1)C2=NN(CC3=CC=CC=C3)C4=C2CCNCC4
InChI
InChIKey=DIQZMBPDLFAJLK-UHFFFAOYSA-N
InChI=1S/C20H20ClN3.C6H8O7/c21-17-8-6-16(7-9-17)20-18-10-12-22-13-11-19(18)24(23-20)14-15-4-2-1-3-5-15;7-3(8)1-6(13,5(11)12)2-4(9)10/h1-9,22H,10-14H2;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
| Molecular Formula | C6H8O7 |
| Molecular Weight | 192.1235 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C20H20ClN3 |
| Molecular Weight | 337.846 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Originator
Approval Year
Sample Use Guides
JNJ-18038683 displaced, with high affinity, specific [3H]5-carboxamidotryptamine binding sites from rat and human 5-hydroxytryptamine type 7 (5-HT7) receptor expressed in HEK293 cells (pKi=8.19+/-0.02 and 8.20+/-0.01, respectively). Similar values are obtained on the native 5-HT7 in membranes from rat thalamus (pKi=8.50+/-0.20). Antagonist potency of JNJ-18038683 is determined by the measurement of adenylate cyclase activity in HEK293 cells expressing the human or rat 5-HT7 receptor. 5-hydroxytryptamine stimulates adenylyl cyclase activity in rat and human 5-HT7/HEK293 cells with a pEC50 of 8.09 and 8.12, respectively.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:03:09 GMT 2023
by
admin
on
Fri Dec 15 16:03:09 GMT 2023
|
| Record UNII |
9UKQ1NQ8YX
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
851376-05-1
Created by
admin on Fri Dec 15 16:03:09 GMT 2023 , Edited by admin on Fri Dec 15 16:03:09 GMT 2023
|
PRIMARY | |||
|
9UKQ1NQ8YX
Created by
admin on Fri Dec 15 16:03:09 GMT 2023 , Edited by admin on Fri Dec 15 16:03:09 GMT 2023
|
PRIMARY | |||
|
11249539
Created by
admin on Fri Dec 15 16:03:09 GMT 2023 , Edited by admin on Fri Dec 15 16:03:09 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
PARENT -> SALT/SOLVATE | |||
|
|
PARENT -> SALT/SOLVATE |
