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Details

Stereochemistry ACHIRAL
Molecular Formula C20H20ClN3.C6H8O7
Molecular Weight 529.9704
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of JNJ-18038683

SMILES

c1ccc(cc1)Cn2c3CCNCCc3c(-c4ccc(cc4)Cl)n2.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

InChI

InChIKey=DIQZMBPDLFAJLK-UHFFFAOYSA-N
InChI=1S/C20H20ClN3.C6H8O7/c21-17-8-6-16(7-9-17)20-18-10-12-22-13-11-19(18)24(23-20)14-15-4-2-1-3-5-15;7-3(8)1-6(13,5(11)12)2-4(9)10/h1-9,22H,10-14H2;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

HIDE SMILES / InChI

Molecular Formula C6H8O7
Molecular Weight 192.1238
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C20H20ClN3
Molecular Weight 337.8466
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

JNJ-18038683 is a 5-hydroxytryptamine type 7 receptor antagonist with potential antidepressant efficacy. It is under development for the treatment of the bipolar disorder.

Approval Year

PubMed

PubMed

TitleDatePubMed
Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder.
2012 Aug
Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity.
2014

Sample Use Guides

10-20 mg/day for 8 weeks.
Route of Administration: Oral
JNJ-18038683 displaced, with high affinity, specific [3H]5-carboxamidotryptamine binding sites from rat and human 5-hydroxytryptamine type 7 (5-HT7) receptor expressed in HEK293 cells (pKi=8.19+/-0.02 and 8.20+/-0.01, respectively). Similar values are obtained on the native 5-HT7 in membranes from rat thalamus (pKi=8.50+/-0.20). Antagonist potency of JNJ-18038683 is determined by the measurement of adenylate cyclase activity in HEK293 cells expressing the human or rat 5-HT7 receptor. 5-hydroxytryptamine stimulates adenylyl cyclase activity in rat and human 5-HT7/HEK293 cells with a pEC50 of 8.09 and 8.12, respectively.
Substance Class Chemical
Created
by admin
on Sat Jun 26 14:16:45 UTC 2021
Edited
by admin
on Sat Jun 26 14:16:45 UTC 2021
Record UNII
9UKQ1NQ8YX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
JNJ-18038683
Common Name English
PYRAZOLO(3,4-D)AZEPINE, 3-(4-CHLOROPHENYL)-1,4,5,6,7,8-HEXAHYDRO-1-(PHENYLMETHYL)-, 2-HYDROXY-1,2,3-PROPANETRICARBOXYLATE (1:1) (SALT)
Common Name English
Code System Code Type Description
CAS
851376-05-1
Created by admin on Sat Jun 26 14:16:45 UTC 2021 , Edited by admin on Sat Jun 26 14:16:45 UTC 2021
PRIMARY
FDA UNII
9UKQ1NQ8YX
Created by admin on Sat Jun 26 14:16:45 UTC 2021 , Edited by admin on Sat Jun 26 14:16:45 UTC 2021
PRIMARY
PUBCHEM
11249539
Created by admin on Sat Jun 26 14:16:45 UTC 2021 , Edited by admin on Sat Jun 26 14:16:45 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE