CHOLINE MONOHYDROGEN CITRATE

US Previously Marketed

First approved in 1945

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H5O7.2C5H14NO.H
Molecular Weight	398.4492
Optical Activity	NONE
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CHOLINE MONOHYDROGEN CITRATE

Structure Search

SMILES

[H+].C[N+](C)(C)CCO.C[N+](C)(C)CCO.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

InChIKey=KGUWSYXISDXUCK-UHFFFAOYSA-L

InChI=1S/C6H8O7.2C5H14NO/c7-3(8)1-6(13,5(11)12)2-4(9)10;2*1-6(2,3)4-5-7/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);2*7H,4-5H2,1-3H3/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	C6H8O7
Molecular Weight	192.1235
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C5H13NO
Molecular Weight	103.1628
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.drugs.com/international/tricholine-citrate.html | http://www.drugsupdate.com/generic/view/1266/Tricholine-citrate

TRICHOLINE CITRATE is indicated for the treatment and management of hepatic disorders and asthma symptoms in adults. It exerts lipotropic action in the hepatic cells. It also can lower the symptoms of asthma and reducing the pro-inflammatory and inflammatory mediators of the leukotriene pathway.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Liver Disorders 3 Sources: https://www.pediatriconcall.com/drugs/tricholine-citrate/900	Primary		Approved 8583	Cypron Approved Use Cyproheptadine Tricholine Citrate & Sorbitol Syrup is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: · Occasional Constipation · Liver Disorders · Asthma Symptoms In Adults · Allergic Reactions · Seasonal Allergies · Mild And Uncomplicated Hives
Asthma 244 Sources: http://wellonapharma.com/product/finished/cyproheptadine-tricholine-citrate-and-sorbitol-syrup	Primary		Approved 8583	Cypron Approved Use Cyproheptadine Tricholine Citrate & Sorbitol Syrup is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: · Occasional Constipation · Liver Disorders · Asthma Symptoms In Adults · Allergic Reactions · Seasonal Allergies · Mild And Uncomplicated Hives

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 2252	inhibitor 2438	inhibitor 2507

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
OCT2 779 OCT1 620 OCT3 159 OCTN2 71 OCTN1 32 CYP1A2 2153 CYP2C19 2057	OCT2 434 OCT1 393

Drug as perpetrator

Target	Modality	Activity	Metabolite
OCT2 782	inhibitor 4027 Sources: https://go.drugbank.com/drugs/DB00122, https://pubmed.ncbi.nlm.nih.gov/12089365/	moderate	CHOLINE 3
OCTN1 32	inhibitor 4027 Sources: https://go.drugbank.com/drugs/DB00122,https://pubmed.ncbi.nlm.nih.gov/10215651/	moderate	CHOLINE 3
OCTN2 71	inhibitor 4027 Sources: https://go.drugbank.com/drugs/DB00122, https://pubmed.ncbi.nlm.nih.gov/9618255/, https://pubmed.ncbi.nlm.nih.gov/10454528/	moderate	CHOLINE 3
CYP1A2 2333	inhibitor 4027 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwzMzU2IiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDkyMCJ9fQ%3D%3D	no [Activation >10 uM]	CHOLINE 3
CYP2C19 2141	inhibitor 4027 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwzNjIyIiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDkyMCJ9fQ%3D%3D	no [Activation >10 uM]	CHOLINE 3
CYP2C9 2497	inhibitor 4027 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwzMzk3IiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDkyMCJ9fQ%3D%3D	no [Activation >10 uM]	CHOLINE 3
CYP2D6 2546	inhibitor 4027 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwyODkiLCJ1c2VfY3VzdG9tX3F1ZXJ5Ijp0cnVlLCJzZWFyY2hfdGVybSI6IiIsInRleHRfZmlsdGVyIjoiQ0hFTUJMOTIwIn19	no [Activation >10 uM]	CHOLINE 3
CYP3A4 2633	inhibitor 4027 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwzNDAiLCJ1c2VfY3VzdG9tX3F1ZXJ5Ijp0cnVlLCJzZWFyY2hfdGVybSI6IiIsInRleHRfZmlsdGVyIjoiQ0hFTUJMOTIwIn19	no [Activation >10 uM]	CHOLINE 3
OCT3 161	inhibitor 4027 Sources: https://go.drugbank.com/drugs/DB00122, https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.22.1_supplement.1217.4	no	CHOLINE 3
OCT1 656	inhibitor 4027 Sources: https://go.drugbank.com/drugs/DB00122, https://jpet.aspetjournals.org/content/286/1/354.short, https://pubmed.ncbi.nlm.nih.gov/18788725/	yes	CHOLINE 3

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
OCT2 434	substrate 4014 Sources: https://go.drugbank.com/drugs/DB00122, https://pubmed.ncbi.nlm.nih.gov/11553644/, https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwxNzQzMTIyIiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDkyMCJ9fQ%3D%3D	yes [Km 102 uM]	CHOLINE 3
OCT1 393	substrate 4014 Sources: https://go.drugbank.com/drugs/DB00122, https://journals.lww.com/jpharmacogenetics/Abstract/2002/11000/Identification_of_genetic_variations_of_the_human.2.aspx	yes	CHOLINE 3

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B8-00470	http://www.3bsc.com/index/pro_info.php?id=67385
Aaron Chemicals	AR003PKN	http://www.aaronchem.com/546-63-4
abcr GmbH	AB140151	http://www.abcr.de/shop/en/AB140151
Alichem	450000867	http://www.alichem.com/en/products/546-63-4.html
Ambinter	Amb22269249	http://www.ambinter.com/reference/22269249
Anward	ANW-41181	http://www.anward.com/pro_result/29969
Aurora Fine Chemicals LLC	A17.880.401	http://online.aurorafinechemicals.com/info?ID=A17.880.401
BLD Pharm	BD121106	http://www.bldpharm.com/products/546-63-4.html
BOC Sciences	546-63-4	https://www.bocsci.com/tricholine-citrate-ca-65-in-water-cas-546-63-4-item-468897.html
Chemspace	CSSB00020625316	https://chem-space.com/CSSB00020625316
eNovation Chemicals	D769432	https://www.enovationchem.com/ProductDetails.asp?ProductID=D769432
Glentham Life Sciences	GV1349	http://www.glentham.com/products/product/GV1349/
Hairui	HR101619	http://www.hairuichem.com/en/product/546-63-4.html
Lab Network	LN01740952	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01740952
MolPort	MolPort-006-111-746	https://www.molport.com/shop/molecule-link/MolPort-006-111-746
MuseChem	M009160	https://www.musechem.com/product/M009160.html
Parchem	40986	https://www.parchem.com/chemical-supplier-distributor/Choline-citrate-040986.aspx
Sigma-Aldrich	T0252_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/t0252?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:10:19 GMT 2025` Edited by `admin` on `Mon Mar 31 18:10:19 GMT 2025`
Record UNII	J18484727O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ETHANAMINIUM, 2-HYDROXY-N,N,N-TRIMETHYL-, 2-HYDROXY-1,2,3-PROPANETRICARBOXYLATE (2:1)

Preferred Name

English

CHOLINE MONOHYDROGEN CITRATE

Systematic Name

English

Code System Code Type Description

CAS

17159-56-7

Created by admin on Mon Mar 31 18:10:19 GMT 2025 , Edited by admin on Mon Mar 31 18:10:19 GMT 2025

PRIMARY

PUBCHEM

72941518

Created by admin on Mon Mar 31 18:10:19 GMT 2025 , Edited by admin on Mon Mar 31 18:10:19 GMT 2025

PRIMARY

FDA UNII

J18484727O

Created by admin on Mon Mar 31 18:10:19 GMT 2025 , Edited by admin on Mon Mar 31 18:10:19 GMT 2025

PRIMARY

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Details

SMILES

InChI

DescriptionSources: https://www.drugs.com/international/tricholine-citrate.html | http://www.drugsupdate.com/generic/view/1266/Tricholine-citrate

Approval Year

Conditions

Approved Use

Approved Use

Overview

OverviewOther

Drug as perpetrator​

Drug as victim

Sourcing

Description
Sources: https://www.drugs.com/international/tricholine-citrate.html | http://www.drugsupdate.com/generic/view/1266/Tricholine-citrate

Drug as perpetrator