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Details

Stereochemistry ACHIRAL
Molecular Formula 2C6H5O7.3Mn.10H2O
Molecular Weight 723.1669
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MANGANESE CITRATE DECAHYDRATE

SMILES

C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Mn+2].[Mn+2].[Mn+2].O.O.O.O.O.O.O.O.O.O

InChI

InChIKey=ZOLZOTLXESSOMN-UHFFFAOYSA-H
InChI=1S/2C6H8O7.3Mn.10H2O/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;;;;;;;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;10*1H2/q;;3*+2;;;;;;;;;;/p-6

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H8O7
Molecular Weight 192.1238
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Mn
Molecular Weight 54.938
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Manganese monoxide is an inorganic compound with chemical formula MnO, a component of fertilizers and food additives. Manganese monoxide nanoparticles (MnO NPs) have been regarded as a new class of T1-positive contrast agents. Manganese oxide nanoparticles may be used for cancer targeted siRNA delivery and magnetic resonance imaging.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Manganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese.
Primary
Unknown

Approved Use

Manganese is used for weak bones (osteoporosis).
Palliative
Unknown

Approved Use

Early research suggests that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension.
Curative
MANGANESE SULFATE

Approved Use

Manganese Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Primary
MANGANESE SULFATE

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Metabolism of l-Tyrosine to 4-Hydroxybenzaldehyde and 3-Bromo-4-Hydroxybenzaldehyde by Chloroplast-containing Fractions of Odonthalia floccosa (Esp.) Falk.
1979 Dec
Effect of quantity and route of administration of manganese monoxide on feed intake and serum manganese in ruminants.
1985 Feb
Manganese citrate improves base-calling accuracy in DNA sequencing reactions using rhodamine-based fluorescent dye-terminators.
1999 Mar 1
Equilibrium and kinetics studies of reactions of manganese acetate, cobalt acetate, and bromide salts in acetic acid solutions.
2001 Jun 18
Differential ability of transition metals to induce pulmonary inflammation.
2001 Nov 15
Tetraaqua(1,10-phenanthroline-kappa(2)N,N')manganese(II) sulfate dihydrate.
2002 Jul
Is the axial zero-field splitting parameter of tetragonally elongated high-spin manganese(III) complexes always negative?
2002 Jul 31
Bi- and poly-metallic cyanide-bridged complexes of the redox-active cyanomanganese nitrosyl unit [Mn(CN)(PR3)(NO)(eta-C5H4Me)].
2004 Feb 21
CsR(R(6)CoI(12))2 (R = Gd, Er) and (CeI)0.26(Ce(6)MnI(9))2: two new structure types featuring R(6)Z clusters.
2006 Nov 27
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.
2006 Summer
Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.
2007 Jun
Effects of chronic manganese exposure on glutamatergic and GABAergic neurotransmitter markers in the nonhuman primate brain.
2009 Sep
Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics.
2014 May
Controlled Synthesis of Hollow Manganese Oxide Nanocrystals.
2016 Feb
Yolk-Shell MnO@ZnMn(2) O(4) /N-C Nanorods Derived from α-MnO(2) /ZIF-8 as Anode Materials for Lithium Ion Batteries.
2016 Oct
Top-Down Strategy to Synthesize Mesoporous Dual Carbon Armored MnO Nanoparticles for Lithium-Ion Battery Anodes.
2017 Apr 12
Intramolecular Aminoalkoxylation of Unfunctionalized Olefins via Intramolecular Iodoamination and Aziridinium Ion Ring-Opening Sequence.
2017 Apr 7
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Curator's Comment:: In vitro cytotoxicity of manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 ug/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells) was studied. The cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 ug/ml MnO nanoparticle.
Unknown
Substance Class Chemical
Created
by admin
on Fri Jun 25 22:39:59 UTC 2021
Edited
by admin
on Fri Jun 25 22:39:59 UTC 2021
Record UNII
4Z2OA6A13N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MANGANESE CITRATE DECAHYDRATE
Systematic Name English
TRIMANGANESE DICITRATE DECAHYDRATE
Common Name English
MANGANESE CITRATE
FCC   WHO-DD  
Systematic Name English
1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, MANGANESE(2+) SALT, HYDRATE (2:3:10)
Common Name English
MANGANESE CITRATE [WHO-DD]
Common Name English
MANGANESE CITRATE [FCC]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 184.1449
Created by admin on Fri Jun 25 22:39:59 UTC 2021 , Edited by admin on Fri Jun 25 22:39:59 UTC 2021
Code System Code Type Description
RXCUI
1791698
Created by admin on Fri Jun 25 22:39:59 UTC 2021 , Edited by admin on Fri Jun 25 22:39:59 UTC 2021
ALTERNATIVE
DRUG BANK
DB14495
Created by admin on Fri Jun 25 22:39:59 UTC 2021 , Edited by admin on Fri Jun 25 22:39:59 UTC 2021
PRIMARY
FDA UNII
4Z2OA6A13N
Created by admin on Fri Jun 25 22:39:59 UTC 2021 , Edited by admin on Fri Jun 25 22:39:59 UTC 2021
PRIMARY
CAS
96030-94-3
Created by admin on Fri Jun 25 22:39:59 UTC 2021 , Edited by admin on Fri Jun 25 22:39:59 UTC 2021
PRIMARY
RXCUI
283767
Created by admin on Fri Jun 25 22:39:59 UTC 2021 , Edited by admin on Fri Jun 25 22:39:59 UTC 2021
PRIMARY RxNorm
PUBCHEM
71587363
Created by admin on Fri Jun 25 22:39:59 UTC 2021 , Edited by admin on Fri Jun 25 22:39:59 UTC 2021
PRIMARY
EPA CompTox
96030-94-3
Created by admin on Fri Jun 25 22:39:59 UTC 2021 , Edited by admin on Fri Jun 25 22:39:59 UTC 2021
PRIMARY
EVMPD
SUB14469MIG
Created by admin on Fri Jun 25 22:39:59 UTC 2021 , Edited by admin on Fri Jun 25 22:39:59 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY