U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Mn
Molecular Weight 54.938
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of MANGANESE CATION (2+)

SMILES

[Mn+2]

InChI

InChIKey=WAEMQWOKJMHJLA-UHFFFAOYSA-N
InChI=1S/Mn/q+2

HIDE SMILES / InChI

Molecular Formula Mn
Molecular Weight 54.938
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Manganese monoxide is an inorganic compound with chemical formula MnO, a component of fertilizers and food additives. Manganese monoxide nanoparticles (MnO NPs) have been regarded as a new class of T1-positive contrast agents. Manganese oxide nanoparticles may be used for cancer targeted siRNA delivery and magnetic resonance imaging.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Manganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese.
Primary
Unknown

Approved Use

Manganese is used for weak bones (osteoporosis).
Palliative
Unknown

Approved Use

Early research suggests that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension.
Curative
MANGANESE SULFATE

Approved Use

Manganese Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Primary
MANGANESE SULFATE

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Cytochrome oxidase determination using a manganese citrate complex.
1970
Metabolism of l-Tyrosine to 4-Hydroxybenzaldehyde and 3-Bromo-4-Hydroxybenzaldehyde by Chloroplast-containing Fractions of Odonthalia floccosa (Esp.) Falk.
1979 Dec
Effect of fluoride on copper, manganese and zinc in bone and kidney.
1981 Mar
Effect of quantity and route of administration of manganese monoxide on feed intake and serum manganese in ruminants.
1985 Feb
Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure.
1993 Jul
Dietary calcium and manganese effects on menstrual cycle symptoms.
1993 May
Manganese citrate improves base-calling accuracy in DNA sequencing reactions using rhodamine-based fluorescent dye-terminators.
1999 Mar 1
Manganese: brain transport and emerging research needs.
2000 Jun
Manganese citrate chemistry: syntheses, spectroscopic studies, and structural characterizations of novel mononuclear, water-soluble manganese citrate complexes.
2000 Sep 4
Equilibrium and kinetics studies of reactions of manganese acetate, cobalt acetate, and bromide salts in acetic acid solutions.
2001 Jun 18
Differential ability of transition metals to induce pulmonary inflammation.
2001 Nov 15
Tetraaqua(1,10-phenanthroline-kappa(2)N,N')manganese(II) sulfate dihydrate.
2002 Jul
Is the axial zero-field splitting parameter of tetragonally elongated high-spin manganese(III) complexes always negative?
2002 Jul 31
Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate.
2002 Sep
Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of managanese citrate as well as manganese and manganese transferrin.
2003 Jan
Bi- and poly-metallic cyanide-bridged complexes of the redox-active cyanomanganese nitrosyl unit [Mn(CN)(PR3)(NO)(eta-C5H4Me)].
2004 Feb 21
Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism.
2005 Mar
Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation.
2005 May
Decreased expression of inflammation-related genes following inhalation exposure to manganese.
2006 May
CsR(R(6)CoI(12))2 (R = Gd, Er) and (CeI)0.26(Ce(6)MnI(9))2: two new structure types featuring R(6)Z clusters.
2006 Nov 27
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.
2006 Summer
Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.
2007 Jun
Effects of chronic manganese exposure on glutamatergic and GABAergic neurotransmitter markers in the nonhuman primate brain.
2009 Sep
Expression profile analysis of antioxidative stress and developmental pathway genes in the manganese-exposed intertidal copepod Tigriopus japonicus with 6K oligochip.
2013 Aug
Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics.
2014 May
Controlled Synthesis of Hollow Manganese Oxide Nanocrystals.
2016 Feb
Chronic exposure to manganese sulfate leads to adverse dose-dependent effects on the neurobehavioral ability of rats.
2016 Nov
Yolk-Shell MnO@ZnMn2 O4 /N-C Nanorods Derived from α-MnO2 /ZIF-8 as Anode Materials for Lithium Ion Batteries.
2016 Oct
Top-Down Strategy to Synthesize Mesoporous Dual Carbon Armored MnO Nanoparticles for Lithium-Ion Battery Anodes.
2017 Apr 12
Intramolecular Aminoalkoxylation of Unfunctionalized Olefins via Intramolecular Iodoamination and Aziridinium Ion Ring-Opening Sequence.
2017 Apr 7
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Curator's Comment:: In vitro cytotoxicity of manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 ug/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells) was studied. The cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 ug/ml MnO nanoparticle.
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 01:08:56 UTC 2021
Edited
by admin
on Sat Jun 26 01:08:56 UTC 2021
Record UNII
H6EP7W5457
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MANGANESE CATION (2+)
Common Name English
MANGANESE, ION (MN2+)
Common Name English
MANGANESE(II) ION
Common Name English
MANGANESE CATION (MN2+)
Common Name English
MANGANESE ION(2+)
Common Name English
Classification Tree Code System Code
NDF-RT N0000180184
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
NDF-RT N0000175862
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
Code System Code Type Description
EPA CompTox
16397-91-4
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
PRIMARY
RXCUI
1546272
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
PRIMARY RxNorm
NCI_THESAURUS
C68267
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
PRIMARY
FDA UNII
H6EP7W5457
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
PRIMARY
CAS
16397-91-4
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
PRIMARY
PUBCHEM
27854
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY