MANGANOUS CATION

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Mn
Molecular Weight	54.938045
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	2

SHOW SMILES / InChI

Structure Search

SMILES

[Mn++]

InChI

InChIKey=WAEMQWOKJMHJLA-UHFFFAOYSA-N

InChI=1S/Mn/q+2

HIDE SMILES / InChI

Molecular Formula	Mn
Molecular Weight	54.938045
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3725729 | https://www.ncbi.nlm.nih.gov/pubmed/3989083 | https://www.ncbi.nlm.nih.gov/pubmed/25464291 | https://www.ncbi.nlm.nih.gov/pubmed/20934746https://www.drugs.com/pro/manganese-sulfate-injection.htmlhttps://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184 | https://www.ncbi.nlm.nih.gov/pubmed/24861367https://www.alfa.com/en/catalog/032808/https://google.com/patents/CN104529454A?http://www.druginfosys.com/drug.aspx?drugcode=2295&type=1https://www.ncbi.nlm.nih.gov/pubmed/6658791http://pubs.acs.org/doi/pdfplus/10.1021/jo970656j
Curator's Comment: description was created based on several sources, including http://sites.chem.colostate.edu/diverdi/all_courses/CRC%20reference%20data/solubility%20of%20inorganic%20compounds.pdf | https://www.google.com/patents/DE102016209961A1

Manganese Bromide is a highly water soluble crystalline salt composed of manganese and bromine with the formula MnBr2. Manganese Bromide can be used in place of palladium in the Stille reaction, which couples two carbon atoms using an organotin compound

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Arginase-1 25 Target ID: CHEMBL1075097 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19032027	Activator 1447
Arginase-2, mitochondrial 24 Target ID: CHEMBL1795148 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25974698	Activator 1447
Glutamine synthetase 29 Target ID: CHEMBL4612 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25974698	Activator 1447

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2596
Unknown 2596
Unknown 2596
Cancer 609 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20934746	Primary	Basic research	Unknown Approved Use Unknown
Manganese deficiency 27 Sources: http://www.webmd.com/vitamins-supplements/ingredientmono-182-manganese.aspx?activeingredientid=182&	Primary	Approved 8583	Unknown Approved Use Manganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese.
Osteoporosis 101 Sources: http://www.webmd.com/vitamins-supplements/ingredientmono-182-manganese.aspx?activeingredientid=182&	Primary	Approved 8583	Unknown Approved Use Manganese is used for weak bones (osteoporosis).
Premenstrual syndrome 38 Sources: http://www.webmd.com/vitamins-supplements/ingredientmono-182-manganese.aspx?activeingredientid=182&	Palliative	Approved 8583	Unknown Approved Use Early research suggests that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension.
Manganese deficiency 27 Sources: https://www.drugs.com/pro/manganese-sulfate-injection.html	Curative	Approved 8583	MANGANESE SULFATE Approved Use Manganese Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Unknown 2596
Unknown 2596
Gastrointestinal disorders 94 Sources: https://www.drugs.com/cdi/magnesium-sulfate.html	Primary	Approved 8583	MANGANESE SULFATE Approved Use Unknown

PubMed

Title	Date	PubMed
Metabolism of l-Tyrosine to 4-Hydroxybenzaldehyde and 3-Bromo-4-Hydroxybenzaldehyde by Chloroplast-containing Fractions of Odonthalia floccosa (Esp.) Falk.	1979 Dec	16661087
Effect of fluoride on copper, manganese and zinc in bone and kidney.	1981 Mar	7284642
Dietary calcium and manganese effects on menstrual cycle symptoms.	1993 May	8498421
Manganese citrate chemistry: syntheses, spectroscopic studies, and structural characterizations of novel mononuclear, water-soluble manganese citrate complexes.	2000 Sep 4	11198859
Differential ability of transition metals to induce pulmonary inflammation.	2001 Nov 15	11708899
Is the axial zero-field splitting parameter of tetragonally elongated high-spin manganese(III) complexes always negative?	2002 Jul 31	12137507
Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate.	2002 Sep	12387356
Bi- and poly-metallic cyanide-bridged complexes of the redox-active cyanomanganese nitrosyl unit [Mn(CN)(PR3)(NO)(eta-C5H4Me)].	2004 Feb 21	15252534
Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism.	2005 Mar	15601679
Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation.	2005 May	15894815
Decreased expression of inflammation-related genes following inhalation exposure to manganese.	2006 May	16476481
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.	2006 Summer	16943606
Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.	2007 Jun	17347134
Effects of chronic manganese exposure on glutamatergic and GABAergic neurotransmitter markers in the nonhuman primate brain.	2009 Sep	19520674
Expression profile analysis of antioxidative stress and developmental pathway genes in the manganese-exposed intertidal copepod Tigriopus japonicus with 6K oligochip.	2013 Aug	23714145
Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics.	2014 May	24861367
Chronic exposure to manganese sulfate leads to adverse dose-dependent effects on the neurobehavioral ability of rats.	2016 Nov	26097037
Yolk-Shell MnO@ZnMn(2) O(4) /N-C Nanorods Derived from α-MnO(2) /ZIF-8 as Anode Materials for Lithium Ion Batteries.	2016 Oct	27562457
Top-Down Strategy to Synthesize Mesoporous Dual Carbon Armored MnO Nanoparticles for Lithium-Ion Battery Anodes.	2017 Apr 12	28333439

Patents

Sample Use Guides

In Vivo Use Guide

Broiler chicks:A basal corn-soybean meal diet (35 ppm Mn) was supplemented with 40, 80, or 120 ppm Mn from Manganese monoxide and fed ad libitum for 21 days.

Route of Administration: Oral

In Vitro Use Guide

Naked Manganese monoxide (MnO) nanoparticles had the cytototoxic effect with IC50 value more than 0.1 mg/ml in BRL 3A rat liver cells.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:30:46 GMT 2025` Edited by `admin` on `Mon Mar 31 18:30:46 GMT 2025`
Record UNII	H6EP7W5457
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MANGANOUS CATION

Common Name

English

MANGANESE ION(2+)

Preferred Name

English

MANGANESE, ION (MN2+)

Common Name

English

MANGANESE(II) ION

Common Name

English

MANGANESE(II)

Systematic Name

English

MANGANESE CATION (MN2+)

Common Name

English

MANGANESE CATION (2+)

Common Name

English

MANGANESE DICATION

Common Name

English

MANGANESE(2+)

Systematic Name

English

Classification Tree Code System Code

NDF-RT

N0000180184