U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Mn
Molecular Weight 54.938
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of MANGANOUS CATION

SMILES

[Mn++]

InChI

InChIKey=WAEMQWOKJMHJLA-UHFFFAOYSA-N
InChI=1S/Mn/q+2

HIDE SMILES / InChI
Molecular Formula Mn
Molecular Weight 54.938
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260883.htm

Manganese citrate is generally recognized as safe direct food additive. Manganese citrate complex has being used in the determination of liver enzyme activities in the aging process and following treatment with aminoethylisothiuronium bromide hydrobromide (AET).

CNS Activity

Originator

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Activator
1430
Activator
1430
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8429
Unknown

Approved Use

Manganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese.
Primary
Approved
8429
Unknown

Approved Use

Manganese is used for weak bones (osteoporosis).
Palliative
Approved
8429
Unknown

Approved Use

Early research suggests that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension.
Curative
Approved
8429
MANGANESE SULFATE

Approved Use

Manganese Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Primary
Approved
8429
MANGANESE SULFATE

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Cytochrome oxidase determination using a manganese citrate complex.
1970
Metabolism of l-Tyrosine to 4-Hydroxybenzaldehyde and 3-Bromo-4-Hydroxybenzaldehyde by Chloroplast-containing Fractions of Odonthalia floccosa (Esp.) Falk.
1979 Dec
Effect of fluoride on copper, manganese and zinc in bone and kidney.
1981 Mar
Effect of quantity and route of administration of manganese monoxide on feed intake and serum manganese in ruminants.
1985 Feb
Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure.
1993 Jul
Dietary calcium and manganese effects on menstrual cycle symptoms.
1993 May
Manganese citrate improves base-calling accuracy in DNA sequencing reactions using rhodamine-based fluorescent dye-terminators.
1999 Mar 1
Manganese: brain transport and emerging research needs.
2000 Jun
Manganese citrate chemistry: syntheses, spectroscopic studies, and structural characterizations of novel mononuclear, water-soluble manganese citrate complexes.
2000 Sep 4
Equilibrium and kinetics studies of reactions of manganese acetate, cobalt acetate, and bromide salts in acetic acid solutions.
2001 Jun 18
Differential ability of transition metals to induce pulmonary inflammation.
2001 Nov 15
Tetraaqua(1,10-phenanthroline-kappa(2)N,N')manganese(II) sulfate dihydrate.
2002 Jul
Is the axial zero-field splitting parameter of tetragonally elongated high-spin manganese(III) complexes always negative?
2002 Jul 31
Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate.
2002 Sep
Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of managanese citrate as well as manganese and manganese transferrin.
2003 Jan
Bi- and poly-metallic cyanide-bridged complexes of the redox-active cyanomanganese nitrosyl unit [Mn(CN)(PR3)(NO)(eta-C5H4Me)].
2004 Feb 21
Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism.
2005 Mar
Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation.
2005 May
Decreased expression of inflammation-related genes following inhalation exposure to manganese.
2006 May
CsR(R(6)CoI(12))2 (R = Gd, Er) and (CeI)0.26(Ce(6)MnI(9))2: two new structure types featuring R(6)Z clusters.
2006 Nov 27
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.
2006 Summer
Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.
2007 Jun
Effects of chronic manganese exposure on glutamatergic and GABAergic neurotransmitter markers in the nonhuman primate brain.
2009 Sep
Expression profile analysis of antioxidative stress and developmental pathway genes in the manganese-exposed intertidal copepod Tigriopus japonicus with 6K oligochip.
2013 Aug
Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics.
2014 May
Controlled Synthesis of Hollow Manganese Oxide Nanocrystals.
2016 Feb
Chronic exposure to manganese sulfate leads to adverse dose-dependent effects on the neurobehavioral ability of rats.
2016 Nov
Yolk-Shell MnO@ZnMn(2) O(4) /N-C Nanorods Derived from α-MnO(2) /ZIF-8 as Anode Materials for Lithium Ion Batteries.
2016 Oct
Top-Down Strategy to Synthesize Mesoporous Dual Carbon Armored MnO Nanoparticles for Lithium-Ion Battery Anodes.
2017 Apr 12
Intramolecular Aminoalkoxylation of Unfunctionalized Olefins via Intramolecular Iodoamination and Aziridinium Ion Ring-Opening Sequence.
2017 Apr 7
Patents

Patents

04048185
23
05089050
24
05261953
23
05629274
23
05700944
23
06136455
24
06548713
23
07091342
25
07384965
26
07544707
26
07598266
24
07615520
24
08460631
23
20020169331
23
20050222440
23
20060205615
24
20060205744
23
20090196809
23
20110203659
23
6589693
23
6627256
23
7435361
26
7687047
23
CA2165259A1
23
CA2517370C
23
DE102016209961
23
EP1627663A3
23
JP 2001058829 A
23
US 3585022 A
23
US20150218342
23
US2825631
23
US2916504
23
US2952519
26

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Curator's Comment: In vitro cytotoxicity of manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 ug/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells) was studied. The cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 ug/ml MnO nanoparticle.
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:32:23 GMT 2023
Edited
by admin
on Fri Dec 15 16:32:23 GMT 2023
Record UNII
H6EP7W5457
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MANGANOUS CATION
Common Name English
MANGANESE, ION (MN2+)
Common Name English
MANGANESE(II) ION
Common Name English
MANGANESE(II)
Systematic Name English
MANGANESE CATION (MN2+)
Common Name English
MANGANESE ION(2+)
Common Name English
MANGANESE CATION (2+)
Common Name English
MANGANESE DICATION
Common Name English
MANGANESE(2+)
Systematic Name English
Classification Tree Code System Code
NDF-RT N0000180184
Created by admin on Fri Dec 15 16:32:24 GMT 2023 , Edited by admin on Fri Dec 15 16:32:24 GMT 2023
NDF-RT N0000175862
Created by admin on Fri Dec 15 16:32:24 GMT 2023 , Edited by admin on Fri Dec 15 16:32:24 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID00167687
Created by admin on Fri Dec 15 16:32:24 GMT 2023 , Edited by admin on Fri Dec 15 16:32:24 GMT 2023
PRIMARY
CHEBI
29035
Created by admin on Fri Dec 15 16:32:24 GMT 2023 , Edited by admin on Fri Dec 15 16:32:24 GMT 2023
PRIMARY
RXCUI
1546272
Created by admin on Fri Dec 15 16:32:24 GMT 2023 , Edited by admin on Fri Dec 15 16:32:24 GMT 2023
PRIMARY RxNorm
DAILYMED
H6EP7W5457
Created by admin on Fri Dec 15 16:32:24 GMT 2023 , Edited by admin on Fri Dec 15 16:32:24 GMT 2023
PRIMARY
SMS_ID
100000179980
Created by admin on Fri Dec 15 16:32:24 GMT 2023 , Edited by admin on Fri Dec 15 16:32:24 GMT 2023
PRIMARY
NCI_THESAURUS
C68267
Created by admin on Fri Dec 15 16:32:24 GMT 2023 , Edited by admin on Fri Dec 15 16:32:24 GMT 2023
PRIMARY
FDA UNII
H6EP7W5457
Created by admin on Fri Dec 15 16:32:24 GMT 2023 , Edited by admin on Fri Dec 15 16:32:24 GMT 2023
PRIMARY
CAS
16397-91-4
Created by admin on Fri Dec 15 16:32:24 GMT 2023 , Edited by admin on Fri Dec 15 16:32:24 GMT 2023
PRIMARY
PUBCHEM
27854
Created by admin on Fri Dec 15 16:32:24 GMT 2023 , Edited by admin on Fri Dec 15 16:32:24 GMT 2023
PRIMARY
Related Record Type Details
Structure of MANGANESE CHLORIDE ANHYDROUS
SALT/SOLVATE -> PARENT
Structure of MANGANESE DINITRATE HEXAHYDRATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE PIDOLATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE ACETYLMETHIONATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE BENZOATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE DIFLUORIDE
SALT/SOLVATE -> PARENT
Structure of MANGANESE NITRATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE HYPOPHOSPHITE MONOHYDRATE
SALT/SOLVATE -> PARENT
Structure of HEKLA LAVA
SALT/SOLVATE -> PARENT
Structure of MANGANESE GLUCONATE ANHYDROUS
SALT/SOLVATE -> PARENT
Structure of MANGANESE CARBONATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE LINOLEATE
SALT/SOLVATE -> PARENT
Structure of MANEB
SALT/SOLVATE -> PARENT
Structure of MANGANOUS SULFATE TETRAHYDRATE
SALT/SOLVATE -> PARENT
Structure of MANGAFODIPIR
SALT/SOLVATE -> PARENT
Structure of MANGANOUS SULFATE ANHYDROUS
SALT/SOLVATE -> PARENT
Structure of MANGANESE BROMIDE
SALT/SOLVATE -> PARENT
Structure of IMISOPASEM MANGANESE
SALT/SOLVATE -> PARENT
Structure of MANGANESE SULFATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE PHOSPHATE, DIBASIC
SALT/SOLVATE -> PARENT
Structure of MANGANESE NEODECANOATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE HYPOPHOSPHITE
SALT/SOLVATE -> PARENT
Structure of MANGANESE GLUCONATE DIHYDRATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE MONOXIDE
SALT/SOLVATE -> PARENT
Structure of DISODIUM MANGANESE ETHYLENEDIAMINETETRAACETATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE BUTYRATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE OCTANOATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE ACETATE TETRAHYDRATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE NITRATE TETRAHYDRATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE CITRATE DECAHYDRATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE BROMIDE TETRAHYDRATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE DIMETHYLDITHIOCARBAMATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE ACETATE
SALT/SOLVATE -> PARENT
Structure of MANGANESE 2-GLYCEROPHOSPHATE
SALT/SOLVATE -> PARENT
Structure of MANGAFODIPIR TRISODIUM
SALT/SOLVATE -> PARENT
Structure of MANGANESE CHLORIDE
SALT/SOLVATE -> PARENT
Structure of MANGANESE FUMARATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of MANGANOUS CATION
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966