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Details

Stereochemistry ACHIRAL
Molecular Formula C6H5O7.Fe
Molecular Weight 244.945
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERRIC CITRATE ANHYDROUS

SMILES

[Fe+3].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

InChIKey=NPFOYSMITVOQOS-UHFFFAOYSA-K
InChI=1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3

HIDE SMILES / InChI
Molecular Formula C6H5O7
Molecular Weight 189.0997
Charge -3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=falsehttp://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505https://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttps://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.html
Curator's Comment: description was created based on several sources, including http://www.mfc.co.jp/english/eng/product/sanferol/index.html

Ferric Ammonium EDTA Solution is normally used as a photographic chemical for a bleaching agent in the process of colour washing. It is also used as a complexing, and oxidizing agent & as a fertilizer and catalyst. EDTA acid are colourless, water-soluble solid that are widely used to dissolve scale. The usefulness of these ammonium salts arise because of its role as a chelating agent, i.e. its ability to "sequester" metal ions such as Ca2+ and Fe3+.

Originator

Monsanto Chemicals
43
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1447
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1410
Chelating Agent
143
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8360
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Approved
8360
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8360
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8360
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

9.0935997E11
Palliative
Approved
8360
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

1.40978881E12
PubMed

PubMed

TitleDatePubMed
[Effects of ferric fluoride compounds on dental enamel].
1954 Nov 15
The formation of ferritin from apoferritin. Catalytic action of apoferritin.
1973 Oct
Biological availability of iron supplements for rats, chicks and humans.
1976 Feb
Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats.
1989
Effect of physical exercise and vitamin C on absorption of ferric sodium citrate.
1996 Dec
New phosphate binding agents: ferric compounds.
1999 Jun
Metal-mediated cyclization of aryl and benzyl glycidyl ethers: a complete scenario.
2008 Dec 17
Thermal behavior study and decomposition kinetics of amiodarone hydrochloride under isothermal conditions.
2011 Jun
Oxidative aromatic C-N bond formation: convenient synthesis of N-amino-3-nitrile-indoles via FeBr3-mediated intramolecular cyclization.
2011 May 21
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.
2013 Apr
FeF(3) catalyzed cascade C-C and C-N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition.
2014 May
Nazarov cyclization of 1,4-pentadien-3-ols: preparation of cyclopenta[b]indoles and spiro[indene-1,4'-quinoline]s.
2016 Feb 14
Mechanisms and origins of the switchable regioselectivity of FeBr3-catalyzed [1,2]-aryl and [1,2]-alkyl shifts of α-aryl aldehydes.
2016 Feb 28
Superior electrochemical performance of N-doped nanocrystalline FeF(3)/C with a single-step solid-state process.
2016 Oct 4
Ferric Chloride-induced Murine Thrombosis Models.
2016 Sep 5
Phosphorus recovery from biogas slurry by ultrasound/H(2)O(2) digestion coupled with HFO/biochar adsorption process.
2017 Feb
Patents

Patents

20080188032
43
20090216060
43
6258758
43
US 5206265 A
43
US2385188
43
US3873678
43
US4364871
43
US6881255
43
US6903235
43
US7198668
43
US8071067
43

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
LD50 (Oral, Rat) > 5 000 mg/kg
Route of Administration: Oral
In Vitro Use Guide
U251 cells were exposed to yellow iron oxide (alpha-FeOOH) nanoparticles at the doses of 0, 3.75, 15, 60 and 120 ug/mL. The results showed that the alpha-FeOOH nanoparticles reduced the cell viability and induced necrosis and apoptosis in U251 cells.
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:12:31 UTC 2023
Edited
by admin
on Wed Jul 05 23:12:31 UTC 2023
Record UNII
63G354M39Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERRIC CITRATE ANHYDROUS
Common Name English
NSC-112227
Code English
FERRIC CITRATE [ORANGE BOOK]
Common Name English
Ferric citrate [WHO-DD]
Common Name English
IRON(III) CITRATE
Systematic Name English
FERRIC CITRATE [FCC]
Common Name English
FERRIC CITRATE [INCI]
Common Name English
IRON CITRATE
Systematic Name English
FERRIC CITRATE [MI]
Common Name English
1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, IRON SALT
Common Name English
1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, IRON(3+) SALT (1:1)
Common Name English
FERRIC CITRATE
FCC   INCI   MI   WHO-DD  
INCI  
Official Name English
FERRUM CITRICUM [HPUS]
Common Name English
FERRUM CITRICUM
HPUS  
Common Name English
IRON(III) CITRATE TRIBASIC
Common Name English
2-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID IRON SALT
Common Name English
JTT-751
Code English
Classification Tree Code System Code
CFR 21 CFR 184.1298
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
WHO-ATC B03AB06
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
WHO-ATC V03AE08
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
WHO-VATC QB03AB06
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
Code System Code Type Description
LACTMED
Ferric Citrate
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
DAILYMED
63G354M39Z
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
RXCUI
1594675
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY RxNorm
PUBCHEM
61300
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
ECHA (EC/EINECS)
222-536-6
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
ECHA (EC/EINECS)
219-045-4
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
ALTERNATIVE
EVMPD
SUB13838MIG
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
SMS_ID
100000078721
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
DRUG CENTRAL
4538
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
EPA CompTox
DTXSID0037657
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
CHEBI
144421
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
CAS
2338-05-8
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
NON-SPECIFIC STOICHIOMETRY
FDA UNII
63G354M39Z
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
WIKIPEDIA
Ferric citrate
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
ECHA (EC/EINECS)
249-117-0
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
ALTERNATIVE
CAS
28633-45-6
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
NON-SPECIFIC STOICHIOMETRY
ChEMBL
CHEMBL3301597
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
NSC
112227
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
MERCK INDEX
M5318
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY Merck Index
CAS
3522-50-7
Created by admin on Wed Jul 05 23:12:31 UTC 2023 , Edited by admin on Wed Jul 05 23:12:31 UTC 2023
PRIMARY
Related Record Type Details
Structure of FERRIC CATION
PARENT -> SALT/SOLVATE
Structure of FERRIC CITRATE PENTAHYDRATE
SOLVATE->ANHYDROUS
Structure of FERRIC CITRATE TRIHYDRATE
SOLVATE->ANHYDROUS
Structure of FERRIC CITRATE MONOHYDRATE
SOLVATE->ANHYDROUS
Structure of ANHYDROUS CITRIC ACID
PARENT -> SALT/SOLVATE
Structure of FERRIC CITRATE DIHYDRATE
SOLVATE->ANHYDROUS
Related Record Type Details
Structure of FERRIC CATION
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