U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C6H5O7.Fe
Molecular Weight 244.945
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERRIC CITRATE ANHYDROUS

SMILES

[Fe+3].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

InChIKey=NPFOYSMITVOQOS-UHFFFAOYSA-K
InChI=1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3

HIDE SMILES / InChI

Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H5O7
Molecular Weight 189.0997
Charge -3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Unknown

Approved Use

Unknown
Primary
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Curative
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

2003
Palliative
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
Interaction of omapatrilat with FD&C Blue No. 2 lake during dissolution of modified release tablets.
2007 Jul 18
Fabrication of FeF3 Nanoflowers on CNT branches and their application to high power lithium rechargeable batteries.
2010 Dec 7
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.
2013 Apr
FeF(3) catalyzed cascade C-C and C-N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition.
2014 May
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
2015 Nov 3
Halide Influence on Molecular and Supramolecular Arrangements of Iron Complexes with a 3,5-Bis(2-Pyridyl)-1,2,4,6-Thiatriazine Ligand.
2016 Jun 6
Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes.
2016 May 17
Phosphorus recovery from biogas slurry by ultrasound/H(2)O(2) digestion coupled with HFO/biochar adsorption process.
2017 Feb
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:43:41 GMT 2023
Edited
by admin
on Fri Dec 15 15:43:41 GMT 2023
Record UNII
63G354M39Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERRIC CITRATE ANHYDROUS
Common Name English
NSC-112227
Code English
FERRIC CITRATE [ORANGE BOOK]
Common Name English
Ferric citrate [WHO-DD]
Common Name English
IRON(III) CITRATE
Systematic Name English
FERRIC CITRATE [FCC]
Common Name English
FERRIC CITRATE [INCI]
Common Name English
IRON CITRATE
Systematic Name English
FERRIC CITRATE [MI]
Common Name English
1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, IRON SALT
Common Name English
1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, IRON(3+) SALT (1:1)
Common Name English
FERRIC CITRATE
FCC   INCI   MI   WHO-DD  
INCI  
Official Name English
FERRUM CITRICUM [HPUS]
Common Name English
FERRUM CITRICUM
HPUS  
Common Name English
IRON(III) CITRATE TRIBASIC
Common Name English
2-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID IRON SALT
Common Name English
JTT-751
Code English
Classification Tree Code System Code
CFR 21 CFR 184.1298
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
WHO-ATC B03AB06
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
WHO-ATC V03AE08
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
WHO-VATC QB03AB06
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
Code System Code Type Description
LACTMED
Ferric Citrate
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
DAILYMED
63G354M39Z
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
RXCUI
1594675
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY RxNorm
PUBCHEM
61300
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
ECHA (EC/EINECS)
222-536-6
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
ECHA (EC/EINECS)
219-045-4
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
ALTERNATIVE
EVMPD
SUB13838MIG
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
SMS_ID
100000078721
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
DRUG CENTRAL
4538
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
EPA CompTox
DTXSID0037657
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
CHEBI
144421
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
CAS
2338-05-8
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
NON-SPECIFIC STOICHIOMETRY
FDA UNII
63G354M39Z
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
WIKIPEDIA
Ferric citrate
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
ECHA (EC/EINECS)
249-117-0
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
ALTERNATIVE
CAS
28633-45-6
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
NON-SPECIFIC STOICHIOMETRY
ChEMBL
CHEMBL3301597
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
NSC
112227
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
MERCK INDEX
m5318
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY Merck Index
CAS
3522-50-7
Created by admin on Fri Dec 15 15:43:41 GMT 2023 , Edited by admin on Fri Dec 15 15:43:41 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS
SOLVATE->ANHYDROUS
SOLVATE->ANHYDROUS
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS
Related Record Type Details
ACTIVE MOIETY