FERRIC CITRATE DIHYDRATE

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H5O7.Fe.2H2O
Molecular Weight	280.975
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O.[Fe+3].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

InChIKey=OCVTTZCALKPMIU-UHFFFAOYSA-K

InChI=1S/C6H8O7.Fe.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;2*1H2/q;+3;;/p-3

HIDE SMILES / InChI

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Fe
Molecular Weight	55.845
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H7O7
Molecular Weight	191.1156
Charge	-1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=falsehttps://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttp://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.html
Curator's Comment: description was created based on several sources, including http://www.mfc.co.jp/english/eng/product/sanferol/index.html

Ferric Ammonium EDTA Solution is normally used as a photographic chemical for a bleaching agent in the process of colour washing. It is also used as a complexing, and oxidizing agent & as a fertilizer and catalyst. EDTA acid are colourless, water-soluble solid that are widely used to dissolve scale. The usefulness of these ammonium salts arise because of its role as a chelating agent, i.e. its ability to "sequester" metal ions such as Ca2+ and Fe3+.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
transformed cell apoptotic process 104 Target ID: GO:0006927 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21121365	Activator 1447
Phosphate 40 Target ID: CHEMBL2364184 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdf	Chelating Agent 139

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2596
Dental diseases 41 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13224146 https://www.ncbi.nlm.nih.gov/pubmed/286710	Primary	Basic research	Unknown Approved Use Unknown
Iron deficiency anemia 52 Sources: http://www.mfc.co.jp/english/eng/product/sanferol/page/3_11.html	Primary	Approved 8583	SANFEROL Approved Use It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Unknown 2596
Pain 619 Sources: https://www.drugs.com/inactive/ferric-oxide-yellow-381.html https://www.drugs.com/imprints/op-40-16159.html	Inactive ingredient	Approved 8583	Oxycontin Approved Use OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics. Launch Date 1998
Chronic kidney disease 55 Sources: https://www.drugs.com/pro/ferric-citrate-tablets.html	Palliative	Approved 8583	AURYXIA Approved Use Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis. Launch Date 2014

PubMed

Title	Date	PubMed
Phosphorus recovery from biogas slurry by ultrasound/H2O2 digestion coupled with HFO/biochar adsorption process.	2017-02	27594573
Superior electrochemical performance of N-doped nanocrystalline FeF3/C with a single-step solid-state process.	2016-10-04	27711351
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.	2015-11-03	26478504
Microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions and antimicrobial activities of the products.	2014-08-26	25255747
FeF(3) catalyzed cascade C-C and C-N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition.	2014-05	24504377
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.	2013-04	23376265
Thermal behavior study and decomposition kinetics of amiodarone hydrochloride under isothermal conditions.	2011-06	21449701
Fabrication of FeF3 Nanoflowers on CNT branches and their application to high power lithium rechargeable batteries.	2010-12-07	20954196
Interaction of omapatrilat with FD&C Blue No. 2 lake during dissolution of modified release tablets.	2007-07-18	17398043
Non-invasive and non-destructive micro-XRF and micro-Raman analysis of a decorative wallpaper from the beginning of the 19th century.	2007-02	16838156
New phosphate binding agents: ferric compounds.	1999-06	10361865
Effect of physical exercise and vitamin C on absorption of ferric sodium citrate.	1996-12	8970140
Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats.	1989	2744824
Contact dermatitis to yellow iron oxide.	1985-08	4064645
Biological availability of iron supplements for rats, chicks and humans.	1976-02	1249649
The absorption of iron as supplements in infant cereal and infant formulas.	1975-05	165454
The formation of ferritin from apoferritin. Catalytic action of apoferritin.	1973-10	4797166
The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake.	1972-01	5075227
[Effects of ferric fluoride compounds on dental enamel].	1954-11-15	13224146

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Bovine enamel was treated with 10 mM FeF3 (Ferric fluoride)

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:25:25 GMT 2025` Edited by `admin` on `Mon Mar 31 20:25:25 GMT 2025`
Record UNII	R6V6N63VUJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, IRON(3+) SALT, HYDRATE (1:1:2)

Preferred Name

English

FERRIC CITRATE DIHYDRATE

Common Name

English

IRON(III) CITRATE TRIBASIC DIHYDRATE

Common Name

English

Code System Code Type Description

MESH

C025314