U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Fe
Molecular Weight 55.845
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 3

SHOW SMILES / InChI
Structure of FERRIC CATION

SMILES

[Fe+3]

InChI

InChIKey=VTLYFUHAOXGGBS-UHFFFAOYSA-N
InChI=1S/Fe/q+3

HIDE SMILES / InChI

Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Unknown

Approved Use

Unknown
Primary
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Curative
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

2003
Palliative
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake.
1972 Jan
The formation of ferritin from apoferritin. Catalytic action of apoferritin.
1973 Oct
The absorption of iron as supplements in infant cereal and infant formulas.
1975 May
Biological availability of iron supplements for rats, chicks and humans.
1976 Feb
Contact dermatitis to yellow iron oxide.
1985 Aug
Effect of physical exercise and vitamin C on absorption of ferric sodium citrate.
1996 Dec
New phosphate binding agents: ferric compounds.
1999 Jun
Non-invasive and non-destructive micro-XRF and micro-Raman analysis of a decorative wallpaper from the beginning of the 19th century.
2007 Feb
Interaction of omapatrilat with FD&C Blue No. 2 lake during dissolution of modified release tablets.
2007 Jul 18
Metal-mediated cyclization of aryl and benzyl glycidyl ethers: a complete scenario.
2008 Dec 17
Thermal behavior study and decomposition kinetics of amiodarone hydrochloride under isothermal conditions.
2011 Jun
Oxidative aromatic C-N bond formation: convenient synthesis of N-amino-3-nitrile-indoles via FeBr3-mediated intramolecular cyclization.
2011 May 21
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.
2013 Apr
Microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions and antimicrobial activities of the products.
2014 Aug 26
FeF(3) catalyzed cascade C-C and C-N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition.
2014 May
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
2015 Nov 3
Nazarov cyclization of 1,4-pentadien-3-ols: preparation of cyclopenta[b]indoles and spiro[indene-1,4'-quinoline]s.
2016 Feb 14
Mechanisms and origins of the switchable regioselectivity of FeBr3-catalyzed [1,2]-aryl and [1,2]-alkyl shifts of α-aryl aldehydes.
2016 Feb 28
Halide Influence on Molecular and Supramolecular Arrangements of Iron Complexes with a 3,5-Bis(2-Pyridyl)-1,2,4,6-Thiatriazine Ligand.
2016 Jun 6
Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes.
2016 May 17
Ferric Chloride-induced Murine Thrombosis Models.
2016 Sep 5
Effect of iron and carbon monoxide on fibrinogenase-like degradation of plasmatic coagulation by venoms of four Crotalus species.
2017 Jan
A Simplified Fe-Based PhotoATRP Using Only Monomers and Solvent.
2017 Jul
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:39:59 GMT 2023
Edited
by admin
on Fri Dec 15 15:39:59 GMT 2023
Record UNII
91O4LML611
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERRIC CATION
Common Name English
IRON, ION (FE3+)
Common Name English
IRON(III) ION
Common Name English
FERRIC IRON [VANDF]
Common Name English
FERRIC ION
Common Name English
Classification Tree Code System Code
NDF-RT N0000175597
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
NDF-RT N0000177913
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
Code System Code Type Description
CAS
20074-52-6
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
PRIMARY
PUBCHEM
29936
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
PRIMARY
DRUG BANK
DB13949
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
PRIMARY
EVMPD
SUB64146
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
PRIMARY
SMS_ID
100000156079
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
PRIMARY
CHEBI
29034
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
PRIMARY
DAILYMED
91O4LML611
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
PRIMARY
EPA CompTox
DTXSID9041029
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
PRIMARY
FDA UNII
91O4LML611
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
PRIMARY
EVMPD
SUB130402
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
PRIMARY
RXCUI
1546357
Created by admin on Fri Dec 15 15:39:59 GMT 2023 , Edited by admin on Fri Dec 15 15:39:59 GMT 2023
PRIMARY RxNorm
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