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Details

Stereochemistry ACHIRAL
Molecular Formula Fe
Molecular Weight 55.845
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 3

SHOW SMILES / InChI
Structure of FERRIC CATION

SMILES

[Fe+3]

InChI

InChIKey=VTLYFUHAOXGGBS-UHFFFAOYSA-N
InChI=1S/Fe/q+3

HIDE SMILES / InChI
Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.htmlhttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505https://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttp://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=false
Curator's Comment: description was created based on several sources, including https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol3/pdf/CFR-1996-title21-vol3-sec182-5375.pdf

Ferric sodium pyrophosphate is a salt, produced by combining sodium pyrophosphate with ferric citrate. It is used as a dietary supplement. The substance is generally recognized as safe when used in accordance with good manufacturing practice.

Originator

Monsanto Chemicals
43
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1447
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1410
Chelating Agent
143
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8360
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Approved
8360
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8360
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8360
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

9.0935997E11
Palliative
Approved
8360
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

1.40978881E12
PubMed

PubMed

TitleDatePubMed
[Effects of ferric fluoride compounds on dental enamel].
1954 Nov 15
The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake.
1972 Jan
The formation of ferritin from apoferritin. Catalytic action of apoferritin.
1973 Oct
The absorption of iron as supplements in infant cereal and infant formulas.
1975 May
Biological availability of iron supplements for rats, chicks and humans.
1976 Feb
Contact dermatitis to yellow iron oxide.
1985 Aug
Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats.
1989
Effect of physical exercise and vitamin C on absorption of ferric sodium citrate.
1996 Dec
New phosphate binding agents: ferric compounds.
1999 Jun
Non-invasive and non-destructive micro-XRF and micro-Raman analysis of a decorative wallpaper from the beginning of the 19th century.
2007 Feb
Interaction of omapatrilat with FD&C Blue No. 2 lake during dissolution of modified release tablets.
2007 Jul 18
Metal-mediated cyclization of aryl and benzyl glycidyl ethers: a complete scenario.
2008 Dec 17
Fabrication of FeF3 Nanoflowers on CNT branches and their application to high power lithium rechargeable batteries.
2010 Dec 7
Thermal behavior study and decomposition kinetics of amiodarone hydrochloride under isothermal conditions.
2011 Jun
Oxidative aromatic C-N bond formation: convenient synthesis of N-amino-3-nitrile-indoles via FeBr3-mediated intramolecular cyclization.
2011 May 21
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.
2013 Apr
Microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions and antimicrobial activities of the products.
2014 Aug 26
FeF(3) catalyzed cascade C-C and C-N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition.
2014 May
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
2015 Nov 3
Nazarov cyclization of 1,4-pentadien-3-ols: preparation of cyclopenta[b]indoles and spiro[indene-1,4'-quinoline]s.
2016 Feb 14
Mechanisms and origins of the switchable regioselectivity of FeBr3-catalyzed [1,2]-aryl and [1,2]-alkyl shifts of α-aryl aldehydes.
2016 Feb 28
Halide Influence on Molecular and Supramolecular Arrangements of Iron Complexes with a 3,5-Bis(2-Pyridyl)-1,2,4,6-Thiatriazine Ligand.
2016 Jun 6
Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes.
2016 May 17
Superior electrochemical performance of N-doped nanocrystalline FeF(3)/C with a single-step solid-state process.
2016 Oct 4
Ferric Chloride-induced Murine Thrombosis Models.
2016 Sep 5
Phosphorus recovery from biogas slurry by ultrasound/H(2)O(2) digestion coupled with HFO/biochar adsorption process.
2017 Feb
Effect of iron and carbon monoxide on fibrinogenase-like degradation of plasmatic coagulation by venoms of four Crotalus species.
2017 Jan
A Simplified Fe-Based PhotoATRP Using Only Monomers and Solvent.
2017 Jul
Patents

Patents

20080188032
43
20090216060
43
6258758
43
US 5206265 A
43
US2385188
43
US3873678
43
US4364871
43
US6881255
43
US6903235
43
US7198668
43
US8071067
43

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Bovine enamel was treated with 10 mM FeF3 (Ferric fluoride)
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:09:03 UTC 2023
Edited
by admin
on Wed Jul 05 23:09:03 UTC 2023
Record UNII
91O4LML611
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERRIC CATION
Common Name English
IRON, ION (FE3+)
Common Name English
IRON(III) ION
Common Name English
FERRIC IRON [VANDF]
Common Name English
FERRIC ION
Common Name English
Classification Tree Code System Code
NDF-RT N0000175597
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
NDF-RT N0000177913
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
Code System Code Type Description
CAS
20074-52-6
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
PRIMARY
PUBCHEM
29936
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
PRIMARY
DRUG BANK
DB13949
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
PRIMARY
EVMPD
SUB64146
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
PRIMARY
SMS_ID
100000156079
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
PRIMARY
CHEBI
29034
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
PRIMARY
DAILYMED
91O4LML611
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
PRIMARY
EPA CompTox
DTXSID9041029
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
PRIMARY
FDA UNII
91O4LML611
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
PRIMARY
EVMPD
SUB130402
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
PRIMARY
RXCUI
1546357
Created by admin on Wed Jul 05 23:09:03 UTC 2023 , Edited by admin on Wed Jul 05 23:09:03 UTC 2023
PRIMARY RxNorm
Related Record Type Details
Structure of FERRIC CARBONATE
SALT/SOLVATE -> PARENT
Structure of FERRIC CACODYLATE
SALT/SOLVATE -> PARENT
Structure of POTASSIUM FERRIC FERROCYANIDE
SALT/SOLVATE -> PARENT
Structure of FERRIOXAMINE B MESYLATE
SALT/SOLVATE -> PARENT
Structure of FERRIC SODIUM PYROPHOSPHATE
SALT/SOLVATE -> PARENT
Structure of FERRIC 2-GLYCEROPHOSPHATE
SALT/SOLVATE -> PARENT
FERRUM PHOSPHORICUM
SALT/SOLVATE -> PARENT
Structure of FERROSOFERRIC PHOSPHATE
SALT/SOLVATE -> PARENT
Structure of FERRIC CITRATE DIHYDRATE
SALT/SOLVATE -> PARENT
Structure of FERRIC SODIUM FERROCYANIDE
SALT/SOLVATE -> PARENT
Structure of FERRIC NITRATE NONAHYDRATE
SALT/SOLVATE -> PARENT
Structure of FERROSOFERRIC OXIDE
SALT/SOLVATE -> PARENT
Structure of DEFERASIROX
LIGAND->TARGET
Deferasirox is an orally active chelator that is selective for iron (as Fe3+). It is a tridentate ligand that binds iron with high affinity in a 2:1 ratio.
BINDING
Structure of FERRIC FORMATE
SALT/SOLVATE -> PARENT
Structure of FERRIC PICRATE
SALT/SOLVATE -> PARENT
Structure of FERRIC NITRATE
SALT/SOLVATE -> PARENT
Structure of FERRIC ACETATE, BASIC
SALT/SOLVATE -> PARENT
Structure of FERRIC SUCCINATE
SALT/SOLVATE -> PARENT
Structure of FERRIC SODIUM CITRATE
SALT/SOLVATE -> PARENT
Structure of FERRIC HYPOPHOSPHITE
SALT/SOLVATE -> PARENT
Structure of FERROCHOLINATE
SALT/SOLVATE -> PARENT
Structure of FERRICLATE CALCIUM SODIUM
SALT/SOLVATE -> PARENT
Structure of FERRIC CITRATE MONOHYDRATE
SALT/SOLVATE -> PARENT
Structure of DEFERIPRONE
LIGAND->TARGET
Structure of FERRIC PYROPHOSPHATE
SALT/SOLVATE -> PARENT
Structure of FERRIOXAMINE B
SALT/SOLVATE -> PARENT
Structure of FERRIC FERRICYANIDE
SALT/SOLVATE -> PARENT
Structure of FERRIC CHLORIDE
SALT/SOLVATE -> PARENT
Structure of FERRIC ACETYLACETONATE
SALT/SOLVATE -> PARENT
Structure of FERROUS DIMETHYL ARSENATE
SALT/SOLVATE -> PARENT
Structure of FERRIC CITRATE ANHYDROUS
SALT/SOLVATE -> PARENT
Structure of FERMAGATE
SALT/SOLVATE -> PARENT
Structure of FERRIC HYDROXIDE
SALT/SOLVATE -> PARENT
Structure of IRON POLYMALTOSE
SALT/SOLVATE -> PARENT
Structure of METHYLENE BLUE CATION
SUBSTRATE -> TARGET
Converts Ferric ion to Ferrous Ion in Methemoglobin
Structure of FERRIC NITRILOTRIACETATE
SALT/SOLVATE -> PARENT
Structure of FERRIC CHLORIDE HEXAHYDRATE
SALT/SOLVATE -> PARENT
Structure of FERMAGATE ANHYDROUS
SALT/SOLVATE -> PARENT
Structure of FERRIC AMMONIUM SULFATE ANHYDROUS
SALT/SOLVATE -> PARENT
Structure of FERRIC BROMIDE
SALT/SOLVATE -> PARENT
Structure of FERROCHOLINATE ANHYDROUS
SALT/SOLVATE -> PARENT
Structure of FERRIC CHROMATE
SALT/SOLVATE -> PARENT
Structure of FERRIC ACETATE
SALT/SOLVATE -> PARENT
Structure of FERRIC SULFATE
SALT/SOLVATE -> PARENT
Structure of FERRIC OXIDE YELLOW
SALT/SOLVATE -> PARENT
Structure of FERRIC PHOSPHATE
SALT/SOLVATE -> PARENT
Structure of FERRIC 1-GLYCEROPHOSPHATE
SALT/SOLVATE -> PARENT
Structure of FERRIC OLEATE
SALT/SOLVATE -> PARENT
Structure of FERBAM
SALT/SOLVATE -> PARENT
Structure of FERRIC MALTOL
SALT/SOLVATE -> PARENT
Structure of HEMIN
SALT/SOLVATE -> PARENT
Structure of FERRIC AMMONIUM SULFATE DODECAHYDRATE
SALT/SOLVATE -> PARENT
Structure of SODIUM FERRIC GLUCONATE COMPLEX
SALT/SOLVATE -> PARENT
Structure of FERRIC CITRATE PENTAHYDRATE
SALT/SOLVATE -> PARENT
Structure of FERRIC CITRATE TRIHYDRATE
SALT/SOLVATE -> PARENT
Structure of FERRIC FLUORIDE
SALT/SOLVATE -> PARENT
Structure of SODIUM FEREDETATE
SALT/SOLVATE -> PARENT
Structure of FERRIC SUBSULFATE
SALT/SOLVATE -> PARENT
Structure of FERRIC AMMONIUM FERROCYANIDE
SALT/SOLVATE -> PARENT
Structure of FERRIC THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of FERRIC ARSENATE
SALT/SOLVATE -> PARENT
Structure of HEMATIN
SALT/SOLVATE -> PARENT
Structure of FERRIC FERROCYANIDE
SALT/SOLVATE -> PARENT
Structure of PBT-1033
LIGAND->TARGET
Scientific Literature
Structure of FERPIFOSATE SODIUM
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of FERRIC CATION
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