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Details

Stereochemistry ACHIRAL
Molecular Formula 3Cl.Fe
Molecular Weight 162.204
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERRIC CHLORIDE

SMILES

[Cl-].[Cl-].[Cl-].[Fe+3]

InChI

InChIKey=RBTARNINKXHZNM-UHFFFAOYSA-K
InChI=1S/3ClH.Fe/h3*1H;/q;;;+3/p-3

HIDE SMILES / InChI

Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Unknown

Approved Use

Unknown
Primary
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

9.0935997E11
Curative
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

1.06496642E12
Palliative
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

1.40978881E12
PubMed

PubMed

TitleDatePubMed
The formation of ferritin from apoferritin. Catalytic action of apoferritin.
1973 Oct
Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats.
1989
Effect of physical exercise and vitamin C on absorption of ferric sodium citrate.
1996 Dec
Non-invasive and non-destructive micro-XRF and micro-Raman analysis of a decorative wallpaper from the beginning of the 19th century.
2007 Feb
Interaction of omapatrilat with FD&C Blue No. 2 lake during dissolution of modified release tablets.
2007 Jul 18
Metal-mediated cyclization of aryl and benzyl glycidyl ethers: a complete scenario.
2008 Dec 17
Oxidative aromatic C-N bond formation: convenient synthesis of N-amino-3-nitrile-indoles via FeBr3-mediated intramolecular cyclization.
2011 May 21
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.
2013 Apr
Nazarov cyclization of 1,4-pentadien-3-ols: preparation of cyclopenta[b]indoles and spiro[indene-1,4'-quinoline]s.
2016 Feb 14
Mechanisms and origins of the switchable regioselectivity of FeBr3-catalyzed [1,2]-aryl and [1,2]-alkyl shifts of α-aryl aldehydes.
2016 Feb 28
Superior electrochemical performance of N-doped nanocrystalline FeF(3)/C with a single-step solid-state process.
2016 Oct 4
Ferric Chloride-induced Murine Thrombosis Models.
2016 Sep 5
Phosphorus recovery from biogas slurry by ultrasound/H(2)O(2) digestion coupled with HFO/biochar adsorption process.
2017 Feb
A Simplified Fe-Based PhotoATRP Using Only Monomers and Solvent.
2017 Jul
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:48:38 UTC 2023
Edited
by admin
on Fri Dec 15 15:48:38 UTC 2023
Record UNII
U38V3ZVV3V
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERRIC CHLORIDE
II   INCI   MI   VANDF   WHO-DD  
INCI  
Official Name English
Ferric chloride [WHO-DD]
Common Name English
FERRIC CHLORIDE [MI]
Common Name English
NSC-135798
Code English
FERRIC CHLORIDE ANHYDROUS
Common Name English
FERRIC CHLORIDE, ANHYDROUS
Common Name English
IRON(III) CHLORIDE
HSDB  
Systematic Name English
IRON PERCHLORIDE
Common Name English
FERRIC CHLORIDE [INCI]
Common Name English
IRON TRICHLORIDE
Systematic Name English
FLORES MARTIS
Common Name English
NSC-51150
Code English
IRON(III) CHLORIDE [HSDB]
Common Name English
IRON CHLORIDE (FECL3)
Common Name English
FERRIC CHLORIDE [VANDF]
Common Name English
FERRIC CHLORIDE [II]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 176.170
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
CFR 21 CFR 184.1297
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
EPA PESTICIDE CODE 34901
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
Code System Code Type Description
EVMPD
SUB13836MIG
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
CHEBI
30808
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
MESH
C024555
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
WIKIPEDIA
IRON(III) CHLORIDE
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
CONCEPT Industrial Aid
MERCK INDEX
m5316
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY Merck Index
CAS
7705-08-0
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
NSC
135798
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
DAILYMED
U38V3ZVV3V
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
SMS_ID
100000078720
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
NSC
51150
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
RXCUI
24898
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY RxNorm
DRUG BANK
DB15536
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
EPA CompTox
DTXSID8020622
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
PUBCHEM
24380
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
ECHA (EC/EINECS)
231-729-4
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
HSDB
449
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
NCI_THESAURUS
C76753
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
FDA UNII
U38V3ZVV3V
Created by admin on Fri Dec 15 15:48:38 UTC 2023 , Edited by admin on Fri Dec 15 15:48:38 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS
SOLVATE->ANHYDROUS
Related Record Type Details
ACTIVE MOIETY