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Details

Stereochemistry ACHIRAL
Molecular Formula 3Cl.Fe.6H2O
Molecular Weight 270.296
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERRIC CHLORIDE HEXAHYDRATE

SMILES

O.O.O.O.O.O.[Cl-].[Cl-].[Cl-].[Fe+3]

InChI

InChIKey=NQXWGWZJXJUMQB-UHFFFAOYSA-K
InChI=1S/3ClH.Fe.6H2O/h3*1H;;6*1H2/q;;;+3;;;;;;/p-3

HIDE SMILES / InChI
Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Cl
Molecular Weight 35.453
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: http://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=falsehttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.htmlhttps://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttps://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505
Curator's Comment: description was created based on several sources, including https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol3/pdf/CFR-1996-title21-vol3-sec182-5375.pdf

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Monsanto Chemicals
44
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Chelating Agent
142
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Approved
8429
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8429
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8429
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Curative
Approved
8429
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

2003
Palliative
Approved
8429
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
[Effects of ferric fluoride compounds on dental enamel].
1954 Nov 15
The formation of ferritin from apoferritin. Catalytic action of apoferritin.
1973 Oct
Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats.
1989
Effect of physical exercise and vitamin C on absorption of ferric sodium citrate.
1996 Dec
Interaction of omapatrilat with FD&C Blue No. 2 lake during dissolution of modified release tablets.
2007 Jul 18
Microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions and antimicrobial activities of the products.
2014 Aug 26
FeF(3) catalyzed cascade C-C and C-N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition.
2014 May
Nazarov cyclization of 1,4-pentadien-3-ols: preparation of cyclopenta[b]indoles and spiro[indene-1,4'-quinoline]s.
2016 Feb 14
Mechanisms and origins of the switchable regioselectivity of FeBr3-catalyzed [1,2]-aryl and [1,2]-alkyl shifts of α-aryl aldehydes.
2016 Feb 28
Phosphorus recovery from biogas slurry by ultrasound/H(2)O(2) digestion coupled with HFO/biochar adsorption process.
2017 Feb
Patents

Patents

20080188032
44
20090216060
44
6258758
44
US 5206265 A
44
US2385188
44
US3873678
44
US4364871
44
US6881255
44
US6903235
44
US7198668
44
US8071067
44

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:24:52 GMT 2023
Edited
by admin
on Fri Dec 15 17:24:52 GMT 2023
Record UNII
0I2XIN602U
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
FERRIC CHLORIDE HEXAHYDRATE
EP   MI   WHO-DD  
Common Name English
IRON(3+) CHLORIDE HEXAHYDRATE
Systematic Name English
IRON CHLORIDE (FECL3.6H2O)
Common Name English
FERRIC CHLORIDE HEXAHYDRATE [EP MONOGRAPH]
Common Name English
FERRIC CHLORIDE HEXAHYDRATE [MI]
Common Name English
FERRIC TRICHLORIDE HEXAHYDRATE
Common Name English
FERRUM MURIATICUM [HPUS]
Common Name English
IRON(III) CHLORIDE HEXAHYDRATE
Systematic Name English
FERRUM MURIATICUM
HPUS  
Common Name English
Ferric chloride hexahydrate [WHO-DD]
Common Name English
IRON PERCHLORIDE, HEXAHYDRATE
Common Name English
Code System Code Type Description
MERCK INDEX
m5316
Created by admin on Fri Dec 15 17:24:52 GMT 2023 , Edited by admin on Fri Dec 15 17:24:52 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID30894792
Created by admin on Fri Dec 15 17:24:52 GMT 2023 , Edited by admin on Fri Dec 15 17:24:52 GMT 2023
PRIMARY
SMS_ID
100000078740
Created by admin on Fri Dec 15 17:24:52 GMT 2023 , Edited by admin on Fri Dec 15 17:24:52 GMT 2023
PRIMARY
MESH
C024555
Created by admin on Fri Dec 15 17:24:52 GMT 2023 , Edited by admin on Fri Dec 15 17:24:52 GMT 2023
PRIMARY
EVMPD
SUB13837MIG
Created by admin on Fri Dec 15 17:24:52 GMT 2023 , Edited by admin on Fri Dec 15 17:24:52 GMT 2023
PRIMARY
DAILYMED
0I2XIN602U
Created by admin on Fri Dec 15 17:24:52 GMT 2023 , Edited by admin on Fri Dec 15 17:24:52 GMT 2023
PRIMARY
RXCUI
1323279
Created by admin on Fri Dec 15 17:24:52 GMT 2023 , Edited by admin on Fri Dec 15 17:24:52 GMT 2023
PRIMARY RxNorm
PUBCHEM
24810
Created by admin on Fri Dec 15 17:24:52 GMT 2023 , Edited by admin on Fri Dec 15 17:24:52 GMT 2023
PRIMARY
CHEBI
86254
Created by admin on Fri Dec 15 17:24:52 GMT 2023 , Edited by admin on Fri Dec 15 17:24:52 GMT 2023
PRIMARY
FDA UNII
0I2XIN602U
Created by admin on Fri Dec 15 17:24:52 GMT 2023 , Edited by admin on Fri Dec 15 17:24:52 GMT 2023
PRIMARY
CAS
10025-77-1
Created by admin on Fri Dec 15 17:24:52 GMT 2023 , Edited by admin on Fri Dec 15 17:24:52 GMT 2023
PRIMARY
Related Record Type Details
Structure of FERRIC CHLORIDE
ANHYDROUS->SOLVATE
Structure of FERRIC CATION
PARENT -> SALT/SOLVATE
FERRIC CHLORIDE TINCTURE
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
Structure of FERRIC CATION
ACTIVE MOIETY
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