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Details

Stereochemistry ACHIRAL
Molecular Formula 3Cl.Fe.6H2O
Molecular Weight 270.296
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERRIC CHLORIDE HEXAHYDRATE

SMILES

O.O.O.O.O.O.[Cl-].[Cl-].[Cl-].[Fe+3]

InChI

InChIKey=NQXWGWZJXJUMQB-UHFFFAOYSA-K
InChI=1S/3ClH.Fe.6H2O/h3*1H;;6*1H2/q;;;+3;;;;;;/p-3

HIDE SMILES / InChI
Molecular Formula Cl
Molecular Weight 35.453
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.htmlhttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505https://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttp://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=false
Curator's Comment: description was created based on several sources, including https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol3/pdf/CFR-1996-title21-vol3-sec182-5375.pdf

Ferric sodium pyrophosphate is a salt, produced by combining sodium pyrophosphate with ferric citrate. It is used as a dietary supplement. The substance is generally recognized as safe when used in accordance with good manufacturing practice.

Originator

Monsanto Chemicals
43
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1447
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1410
Chelating Agent
143
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8360
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Approved
8360
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8360
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8360
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

9.0935997E11
Palliative
Approved
8360
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

1.40978881E12
PubMed

PubMed

TitleDatePubMed
[Effects of ferric fluoride compounds on dental enamel].
1954 Nov 15
The absorption of iron as supplements in infant cereal and infant formulas.
1975 May
Biological availability of iron supplements for rats, chicks and humans.
1976 Feb
Contact dermatitis to yellow iron oxide.
1985 Aug
Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats.
1989
Effect of physical exercise and vitamin C on absorption of ferric sodium citrate.
1996 Dec
New phosphate binding agents: ferric compounds.
1999 Jun
Non-invasive and non-destructive micro-XRF and micro-Raman analysis of a decorative wallpaper from the beginning of the 19th century.
2007 Feb
Interaction of omapatrilat with FD&C Blue No. 2 lake during dissolution of modified release tablets.
2007 Jul 18
Metal-mediated cyclization of aryl and benzyl glycidyl ethers: a complete scenario.
2008 Dec 17
Fabrication of FeF3 Nanoflowers on CNT branches and their application to high power lithium rechargeable batteries.
2010 Dec 7
Thermal behavior study and decomposition kinetics of amiodarone hydrochloride under isothermal conditions.
2011 Jun
Microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions and antimicrobial activities of the products.
2014 Aug 26
FeF(3) catalyzed cascade C-C and C-N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition.
2014 May
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
2015 Nov 3
Halide Influence on Molecular and Supramolecular Arrangements of Iron Complexes with a 3,5-Bis(2-Pyridyl)-1,2,4,6-Thiatriazine Ligand.
2016 Jun 6
Ferric Chloride-induced Murine Thrombosis Models.
2016 Sep 5
Phosphorus recovery from biogas slurry by ultrasound/H(2)O(2) digestion coupled with HFO/biochar adsorption process.
2017 Feb
Effect of iron and carbon monoxide on fibrinogenase-like degradation of plasmatic coagulation by venoms of four Crotalus species.
2017 Jan
Patents

Patents

20080188032
43
20090216060
43
6258758
43
US 5206265 A
43
US2385188
43
US3873678
43
US4364871
43
US6881255
43
US6903235
43
US7198668
43
US8071067
43

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Bovine enamel was treated with 10 mM FeF3 (Ferric fluoride)
Substance Class Chemical
Created
by admin
on Thu Jul 06 00:44:55 UTC 2023
Edited
by admin
on Thu Jul 06 00:44:55 UTC 2023
Record UNII
0I2XIN602U
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
FERRIC CHLORIDE HEXAHYDRATE
EP   MI   WHO-DD  
Common Name English
IRON(3+) CHLORIDE HEXAHYDRATE
Systematic Name English
IRON CHLORIDE (FECL3.6H2O)
Common Name English
FERRIC CHLORIDE HEXAHYDRATE [EP MONOGRAPH]
Common Name English
FERRIC CHLORIDE HEXAHYDRATE [MI]
Common Name English
FERRIC TRICHLORIDE HEXAHYDRATE
Common Name English
FERRUM MURIATICUM [HPUS]
Common Name English
IRON(III) CHLORIDE HEXAHYDRATE
Systematic Name English
FERRUM MURIATICUM
HPUS  
Common Name English
Ferric chloride hexahydrate [WHO-DD]
Common Name English
IRON PERCHLORIDE, HEXAHYDRATE
Common Name English
Code System Code Type Description
MERCK INDEX
M5316
Created by admin on Thu Jul 06 00:44:55 UTC 2023 , Edited by admin on Thu Jul 06 00:44:55 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID30894792
Created by admin on Thu Jul 06 00:44:55 UTC 2023 , Edited by admin on Thu Jul 06 00:44:55 UTC 2023
PRIMARY
SMS_ID
100000078740
Created by admin on Thu Jul 06 00:44:55 UTC 2023 , Edited by admin on Thu Jul 06 00:44:55 UTC 2023
PRIMARY
MESH
C024555
Created by admin on Thu Jul 06 00:44:55 UTC 2023 , Edited by admin on Thu Jul 06 00:44:55 UTC 2023
PRIMARY
EVMPD
SUB13837MIG
Created by admin on Thu Jul 06 00:44:55 UTC 2023 , Edited by admin on Thu Jul 06 00:44:55 UTC 2023
PRIMARY
DAILYMED
0I2XIN602U
Created by admin on Thu Jul 06 00:44:55 UTC 2023 , Edited by admin on Thu Jul 06 00:44:55 UTC 2023
PRIMARY
RXCUI
1323279
Created by admin on Thu Jul 06 00:44:55 UTC 2023 , Edited by admin on Thu Jul 06 00:44:55 UTC 2023
PRIMARY RxNorm
PUBCHEM
24810
Created by admin on Thu Jul 06 00:44:55 UTC 2023 , Edited by admin on Thu Jul 06 00:44:55 UTC 2023
PRIMARY
CHEBI
86254
Created by admin on Thu Jul 06 00:44:55 UTC 2023 , Edited by admin on Thu Jul 06 00:44:55 UTC 2023
PRIMARY
FDA UNII
0I2XIN602U
Created by admin on Thu Jul 06 00:44:55 UTC 2023 , Edited by admin on Thu Jul 06 00:44:55 UTC 2023
PRIMARY
CAS
10025-77-1
Created by admin on Thu Jul 06 00:44:55 UTC 2023 , Edited by admin on Thu Jul 06 00:44:55 UTC 2023
PRIMARY
Related Record Type Details
Structure of FERRIC CHLORIDE
ANHYDROUS->SOLVATE
Structure of FERRIC CATION
PARENT -> SALT/SOLVATE
FERRIC CHLORIDE TINCTURE
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
Structure of FERRIC CATION
ACTIVE MOIETY
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