U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H12N2O8.Fe.Na
Molecular Weight 367.046
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM FEREDETATE

SMILES

[Na+].[Fe+3].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

InChIKey=MKWYFZFMAMBPQK-UHFFFAOYSA-J
InChI=1S/C10H16N2O8.Fe.Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;+3;+1/p-4

HIDE SMILES / InChI
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C10H12N2O8
Molecular Weight 288.2109
Charge -4
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: http://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=falsehttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.htmlhttps://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttps://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505
Curator's Comment: description was created based on several sources, including https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol3/pdf/CFR-1996-title21-vol3-sec182-5375.pdf

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Monsanto Chemicals
44
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Chelating Agent
142
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Approved
8429
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8429
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8429
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Curative
Approved
8429
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

2003
Palliative
Approved
8429
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
Effect of physical exercise and vitamin C on absorption of ferric sodium citrate.
1996 Dec
New phosphate binding agents: ferric compounds.
1999 Jun
Oxidative aromatic C-N bond formation: convenient synthesis of N-amino-3-nitrile-indoles via FeBr3-mediated intramolecular cyclization.
2011 May 21
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.
2013 Apr
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
2015 Nov 3
Mechanisms and origins of the switchable regioselectivity of FeBr3-catalyzed [1,2]-aryl and [1,2]-alkyl shifts of α-aryl aldehydes.
2016 Feb 28
Patents

Patents

20080188032
44
20090216060
44
6258758
44
US 5206265 A
44
US2385188
44
US3873678
44
US4364871
44
US6881255
44
US6903235
44
US7198668
44
US8071067
44

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 18:04:56 GMT 2023
Edited
by admin
on Sat Dec 16 18:04:56 GMT 2023
Record UNII
403J23EMFA
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM FEREDETATE
INN   MART.   WHO-DD  
INN  
Official Name English
FERROSTRANE
Brand Name English
SYTRON
Brand Name English
EDETIC ACID SODIUM IRON SALT
Common Name English
SODIUM FEREDETATE [MART.]
Common Name English
IRON(3+) SODIUM 2,2',2'',2'''-(ETHANE-1,2-DIYLDINITRILO)TETRAACETATE (1:1:1)
Systematic Name English
SODIUM IRON EDETATE
Systematic Name English
EDTA FERRIC SODIUM SALT
Common Name English
SODIUM IRON ETHYLENEDIAMINE TETRAACETIC ACID
Systematic Name English
IRON(III) SODIUM ETHYLENEDIAMINETETRAACETATE
Systematic Name English
IRON CHELATE OF THE MONOSODIUM SALT OF (ETHYLENEDINITRILO)TETRAACETIC ACID
Common Name English
SODIUM IRON EDTA
FCC   USP-RS  
Common Name English
SODIUM IRON EDTA [USP-RS]
Common Name English
ETHYLENEDIAMINETETRAACETIC ACID FERRIC SODIUM SALT
Common Name English
SODIUM IRON EDTA [FCC]
Common Name English
sodium feredetate [INN]
Common Name English
FERRIC SODIUM EDETATE [MI]
Common Name English
Sodium feredetate [WHO-DD]
Common Name English
EDTA, IRON (III) SODIUM
Common Name English
NSC-5237
Code English
FERRAZONE
Brand Name English
IRON(III) SODIUM ETHYLENEDIAMINE TETRAACETATE
Systematic Name English
EDTA IRON(III) SODIUM SALT
Common Name English
SYBRON
Brand Name English
Classification Tree Code System Code
WHO-ATC B03AB03
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
EPA PESTICIDE CODE 139114
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
WHO-VATC QB03AB03
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
Code System Code Type Description
DAILYMED
403J23EMFA
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
SMS_ID
100000091544
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
NCI_THESAURUS
C76827
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
GRAS Notification (GRN No.)
152
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
GRAS Notification (GRN No.)
178
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
WIKIPEDIA
Ferric sodium EDTA
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
INN
1122
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
NSC
5237
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
CHEBI
78292
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
FDA UNII
403J23EMFA
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
EVMPD
SUB10560MIG
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
DRUG CENTRAL
4709
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
MERCK INDEX
m5328
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY Merck Index
DRUG BANK
DB13381
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
RXCUI
105673
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID5027774
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
ECHA (EC/EINECS)
239-802-2
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
CONCEPT Dietary Supplement
RS_ITEM_NUM
1614239
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
CAS
15708-41-5
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
PUBCHEM
27461
Created by admin on Sat Dec 16 18:04:56 GMT 2023 , Edited by admin on Sat Dec 16 18:04:56 GMT 2023
PRIMARY
Related Record Type Details
Structure of FERRIC CATION
PARENT -> SALT/SOLVATE
Structure of EDETIC ACID
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of FERRIC CATION
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