Edetic Acid

First approved in 1953

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H16N2O8
Molecular Weight	292.2426
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O

InChI

InChIKey=KCXVZYZYPLLWCC-UHFFFAOYSA-N

InChI=1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)

HIDE SMILES / InChI

Molecular Formula	C10H16N2O8
Molecular Weight	292.2426
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.webmd.com/balance/tc/chelation-therapy-topic-overview#1 | https://www.empowerpharmacy.com/drugs/edetate-disodium-injection.htmlhttp://umm.edu/health/medical/altmed/supplement/ethylenediaminetetraacetic-acid
Curator's Comment: description was created based on several sources, including, http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5508a3.htm

Edetic acid (EDTA) is a chelating agent. The U.S. Food and Drug Administration (FDA) approved edetic acid chelation therapy as a treatment for lead and heavy metal poisoning. Edetic acid in form of disodium salt was withdrawn from the market due to death resulting from hypocalcemia during chelation.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
divalent and trivalent metals 12 Target ID: divalent and trivalent metals Sources: https://www.webmd.com/balance/tc/chelation-therapy-topic-overview#1	Binding Agent 1076
Lead 16 Target ID: CHEMBL2364029 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/008922s016lbl.pdf	Chelating Agent 139		18.3 null [pKd]

Conditions

Condition	Modality	Highest Phase	Product
Lead poisoning 12 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/008922s016lbl.pdf	Curative	Approved 8583	Calcium disodium versenate Approved Use Edetate calcium disodium is indicated for the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults. Launch Date 1953
Lead encephalopathy 12 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/008922s016lbl.pdf	Curative	Approved 8583	Calcium Disodium Versenate Approved Use Edetate calcium disodium is indicated for the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults. Launch Date 1953
Heavy metal poisoning 13 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20537473	Curative	Approved 8583	Unknown Approved Use Unknown
Hypercalcemia 21 Sources: https://www.empowerpharmacy.com/drugs/edetate-disodium-injection.html	Curative	Not Provided 511	Unknown Approved Use Unknown
Ventricular arrhythmias associated with digitalis toxicity 12 Sources: https://www.empowerpharmacy.com/drugs/edetate-disodium-injection.html	Diagnostic	Not Provided 511	Unknown Approved Use Unknown

C_max

Value	Dose	Co-administered	Analyte	Population
51 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3096624	1 g single, intramuscular dose: 1 g route of administration: Intramuscular experiment type: SINGLE co-administered:		EDETATE CALCIUM DISODIUM serum	Homo sapiens population: UNKNOWN age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
60 min DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/008922s016lbl.pdf	unknown, unknown		EDETATE CALCIUM DISODIUM plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
25 mg/kg 2 times / day multiple, intravenous Recommended Dose: 25 mg/kg, 2 times / day Route: intravenous Route: multiple Dose: 25 mg/kg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/7099793	unhealthy, 1-8 Health Status: unhealthy Age Group: 1-8 Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/7099793	Disc. AE: Acute renal failure... Other AEs: Nephrotoxicity... AEs leading to discontinuation/dose reduction: Acute renal failure (3%) Other AEs: Nephrotoxicity (mild, 13%) Sources: https://pubmed.ncbi.nlm.nih.gov/7099793
160 mg/kg single, intravenous Studied dose Dose: 160 mg/kg Route: intravenous Route: single Dose: 160 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/	unhealthy, 49 Health Status: unhealthy Age Group: 49 Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/	Disc. AE: Hypocalcemia... AEs leading to discontinuation/dose reduction: Hypocalcemia Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/
400 mg/kg 1 times / day multiple, intravenous Highest studied dose Dose: 400 mg/kg, 1 times / day Route: intravenous Route: multiple Dose: 400 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/	unhealthy, 58 Health Status: unhealthy Age Group: 58 Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/	Disc. AE: Restlessness, Hypocalcemia... AEs leading to discontinuation/dose reduction: Restlessness Hypocalcemia Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/
400 mg/kg 1 times / day multiple, intravenous Highest studied dose Dose: 400 mg/kg, 1 times / day Route: intravenous Route: multiple Dose: 400 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/	unhealthy, 58 Health Status: unhealthy Age Group: 58 Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/	Disc. AE: Headache... AEs leading to discontinuation/dose reduction: Headache Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/

AEs

AE	Significance	Dose	Population
Acute renal failure	3% Disc. AE	25 mg/kg 2 times / day multiple, intravenous Recommended Dose: 25 mg/kg, 2 times / day Route: intravenous Route: multiple Dose: 25 mg/kg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/7099793	unhealthy, 1-8 Health Status: unhealthy Age Group: 1-8 Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/7099793
Nephrotoxicity	mild, 13%	25 mg/kg 2 times / day multiple, intravenous Recommended Dose: 25 mg/kg, 2 times / day Route: intravenous Route: multiple Dose: 25 mg/kg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/7099793	unhealthy, 1-8 Health Status: unhealthy Age Group: 1-8 Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/7099793
Hypocalcemia	Disc. AE	160 mg/kg single, intravenous Studied dose Dose: 160 mg/kg Route: intravenous Route: single Dose: 160 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/	unhealthy, 49 Health Status: unhealthy Age Group: 49 Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/
Hypocalcemia	Disc. AE	400 mg/kg 1 times / day multiple, intravenous Highest studied dose Dose: 400 mg/kg, 1 times / day Route: intravenous Route: multiple Dose: 400 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/	unhealthy, 58 Health Status: unhealthy Age Group: 58 Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/
Restlessness	Disc. AE	400 mg/kg 1 times / day multiple, intravenous Highest studied dose Dose: 400 mg/kg, 1 times / day Route: intravenous Route: multiple Dose: 400 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/	unhealthy, 58 Health Status: unhealthy Age Group: 58 Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/
Headache	Disc. AE	400 mg/kg 1 times / day multiple, intravenous Highest studied dose Dose: 400 mg/kg, 1 times / day Route: intravenous Route: multiple Dose: 400 mg/kg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/	unhealthy, 58 Health Status: unhealthy Age Group: 58 Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/13121040/

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B4-2695	http://www.3bsc.com/index/pro_info.php?id=77330
AA Blocks	AA003QGC	http://www.aablocks.com/goods/Goods/detail?id=AA003QGC
Aaron Chemicals	AR003R84	http://www.aaronchem.com/60-00-4
abcr GmbH	AB116519	http://www.abcr.com/shop/en/AB116519
abcr GmbH	AB202813	http://www.abcr.com/shop/en/AB202813
abcr GmbH	AB354847	http://www.abcr.com/shop/en/AB354847
abcr GmbH	AB354848	http://www.abcr.com/shop/en/AB354848
abcr GmbH	AB354852	http://www.abcr.com/shop/en/AB354852
AbMole Bioscience	M6699	http://www.abmole.com/products/edta.html
Acadechem	ACDS-021218	http://www.acadechemical.com/product/95917
Achemica	ACMC-209mhe	http://www.achemica.com/prodinfo/?id=129500
Achemtek	0104-009324	http://www.achemtek.com/60-00-4
Acros Organics	AC118430010	https://www.fishersci.com/shop/products/ethylenediaminetetraacetic-acid-99-pure-acros-organics/AC118430010
Acros Organics	AC118430050	https://www.fishersci.com/shop/products/ethylenediaminetetraacetic-acid-99-pure-acros-organics-2/AC118430050
Acros Organics	AC118432500	https://www.fishersci.com/shop/products/ethylenediaminetetraacetic-acid-99-pure-acros-organics/AC118432500
Acros Organics	AC409930050	https://www.fishersci.com/shop/products/ethylenediaminetetraacetic-acid-reagent-acs-99-5-acros-organics/AC409930050
AK Scientific, Inc. (AKSCI)	67869	http://www.aksci.com/item_detail.php?cat=67869
Alfa Aesar	11931	https://www.alfa.com/en/catalog/L11927/
Alfa Aesar	A10713	https://www.alfa.com/en/catalog/A10713/
Alfa Aesar	J60292	https://www.alfa.com/en/catalog/J60292/
Alfa Aesar	J62786	https://www.alfa.com/en/catalog/J62786/
Alfa Aesar	J62948	https://www.alfa.com/en/catalog/J62948/
Alfa Chemistry	470462-56-7	https://www.alfa-chemistry.com/cas_470462-56-7.htm
Alfa Chemistry	AP60004	https://reagents.alfa-chemistry.com/product/edetic-acid-cas-60-00-4-13818.html
Alichem	490009228	http://www.alichem.com/en/products/60-00-4.html
Anward	ANW-33408	http://www.anward.com/pro_result/24113
ApexBio Technology	B7197	http://www.apexbt.com/edta.html
Ark Pharm	AK109916	http://www.arkpharminc.com/products/60-00-4.html
Aurora Fine Chemicals LLC	K01.177.831	http://online.aurorafinechemicals.com/info?ID=K01.177.831
Avantor Inc	100201-854	https://us.vwr.com/store/product/7808204/edta-disodium-salt-dihydrate
Avantor Inc	101224-880	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101224-880
Avantor Inc	200000-460	https://us.vwr.com/store/product/7514334/edta-ethylenediamine-tetraacetic-acid
Avantor Inc	200003-806	https://us.vwr.com/store/product/7520700/edta-disodium-salt-dihydrate-99-acs
Avantor Inc	200006-524	https://us.vwr.com/store/product/7515293/edta-disodium-salt-dihydrate
BioSynth	J-610078	https://www.biosynth.com/en/products/life-science/other-biochemicals/products/J-610078.html
BLD Pharm	BD127148	http://www.bldpharm.com/products/60-00-4.html
BOC Sciences	15251-22-6	https://www.bocsci.com/ethylenediaminetetraacetic-acid-d4-car-cas-15251-22-6-item-152363.html
BOC Sciences	203805-96-3	https://www.bocsci.com/ethylenediaminetetraacetic-acid-d16-cas-203805-96-3-item-79116.html
BOC Sciences	203806-08-0	https://www.bocsci.com/edta-cas-203806-08-0-item-349938.html
Calbiochem	324504	http://www.emdbiosciences.com/product/324504
Chemenu	CM119890	http://www.chemenu.com/products/CM119890
ChemMol	30100576	http://www.chemmol.com/chemmol/30100576.html
ChemMol	49415941	http://www.chemmol.com/chemmol/49415941.html
ChemMol	49425917	http://www.chemmol.com/chemmol/49425917.html
ChemMol	99117790	http://www.chemmol.com/chemmol/99117790.html
Chemspace	CSSB00016998507	https://chem-space.com/CSSB00016998507
China MainChem Co., Ltd	60-00-4	https://www.mainchem.com/product/edta-acid/
Clearsynth	CS-EB-00754	https://www.clearsynth.com/en/CSEB00754.html
Clearsynth	CS-ER-00746	https://www.clearsynth.com/en/CSER00746.html
Clearsynth	CS-T-54458	https://www.clearsynth.com/en/CST54458.html
DC Chemicals	DC37345	http://www.dcchemicals.com//product_show-Sequestrol.html
Debye Scientific	DB-084840	http://www.debyesci.com/cas_124949-23-1.html
Debye Scientific	DS-003836	http://www.debyesci.com/cas_53632-26-1.html
EMD Millipore	324504	http://www.emdbiosciences.com/product/324504
Enamine	Z2688689169	https://www.enaminestore.com/catalog/Z2688689169
eNovation Chemicals	Y1081631	https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1081631
Finetech	FT-0626319	http://www.finetechnology-ind.com/prod/detail/pub/60-00-4.html
Finetech	FT-0668253	http://www.finetechnology-ind.com/prod/detail/pub/1215408-17-5.html
Finetech	FT-0668254	http://www.finetechnology-ind.com/prod/detail/pub/470462-56-7.html
Fisher Chemical	E4781	https://www.fishersci.com/shop/products/ethylenediamine-tetraacetic-acid-certified-acs-fisher-chemical-2/p-127675
Fisher Chemical	E478500	https://www.fishersci.com/shop/products/ethylenediamine-tetraacetic-acid-certified-acs-fisher-chemical-2/p-127675
Glentham Life Sciences	GE4011	http://www.glentham.com/products/product/GE4011/
Hairui	HR130739	http://www.hairuichem.com/en/product/60-00-4.html
iChemical	EBD3431	http://www.ichemical.com/products/60-00-4.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
LGC Standards	DRE-C13110800	https://www.lgcstandards.com/US/en/p/DRE-C13110800
Matrix Scientific	98034	https://www.matrixscientific.com/098034.html
mcule	MCULE-1868494404	https://mcule.com/MCULE-1868494404/
MuseChem	R053901	https://www.musechem.com/product/R053901.html
Oakwood	238173	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=119172&ExtHyperLink=1
Oakwood	99729	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=165594&ExtHyperLink=1
Parchem	11395	http://www.parchem.com/chemical-supplier-distributor/Ethylenediamineteraacetic-Acid-001395.aspx
Parchem	37787	http://www.parchem.com/chemical-supplier-distributor/EDTA-027787.aspx
Renno Tech	RL04264	http://www.rennotech.com/product_show.asp?id=4513
Selleck Chemicals	S6350	http://www.selleckchem.com/products/ethylenediaminetetraacetic-acid.html
Sigma-Aldrich	03609_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/03609?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	03620_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/03620?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	03690_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/03690?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	09-1320_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/091320?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	1233508_USP	https://www.sigmaaldrich.com/catalog/product/usp/1233508?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S005561	http://www.sinfoobiotech.com/product/1008959
Smolecule	S526875	http://www.smolecule.com/products/s526875
Strem Chemicals, Inc.	07-0573	http://www.strem.com/catalog/v/07-0573/
TCI (Tokyo Chemical Industry)	E0084	http://www.tcichemicals.com/eshop/en/us/commodity/E0084/index.html
THE BioTek	bt-267051	https://www.thebiotek.com/product/inhibitors/bt-267051
Tocris	2811	https://www.tocris.com/products/edta_2811
VladaChem	VL142272	https://www.vladachem.com/product.php?products=60-00-4
VladaChem	VL162896	https://www.vladachem.com/product.php?products=60-00-4
VladaChem	VL162965	https://www.vladachem.com/product.php?products=60-00-4
VladaChem	VL167435	https://www.vladachem.com/product.php?products=60-00-4
VladaChem	VL275423-1KG	https://www.vladachem.com/product.php?products=60-00-4
Yuhao Chemical	LT7792	http://www.chemyuhao.com/60-00-4.html
Yuhao Chemical	RT5315	http://www.chemyuhao.com/470462-56-7.html

PubMed

Title	Date	PubMed
Effect of ethylenediaminetetraacetic acid (EDTA) on acute mercury poisoning of toad.	1986	2877801
Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin.	2001	11231886
Hydroxyl radical footprinting of proteins using metal ion complexes.	2001	11219012
Artificial iron-dependent proteases.	2001	11219010
Evaluation of Er:YAG laser and EDTAC on dentin adhesion of six endodontic sealers.	2001	11210246
Attachment of human gingival fibroblasts to periodontally involved root surface following scaling and/or etching procedures: a scanning electron microscopy study.	2001	11210244
Evaluation of copper availability to plants in copper-contaminated vineyard soils.	2001	11202733
Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture--primary culture cells markedly differ from fourth-passage cells.	2001	11178129
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice.	2001	11178110
Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene.	2001	11178108
Brain dystrophin-glycoprotein complex: persistent expression of beta-dystroglycan, impaired oligomerization of Dp71 and up-regulation of utrophins in animal models of muscular dystrophy.	2001	11178104
Chemical speciation used to assess [S,S']-ethylenediaminedisuccinic acid (EDDS) as a readily-biodegradable replacement for EDTA in radiochemical decontamination formulations.	2001 Apr	11225694
Cloning and biochemical characterization of BglC, a beta-glucosidase from the cellulolytic actinomycete Thermobifida fusca.	2001 Apr	11178732
Quantitation of genomic DNA in plasma and serum samples: higher concentrations of genomic DNA found in serum than in plasma.	2001 Feb	11239235
Anti-Saccharomyces cerevisiae antibodies (ASCA), phenotypes of IBD, and intestinal permeability: a study in IBD families.	2001 Feb	11233666
Prolonged stability of endogenous cardiotrophin-1 in whole blood.	2001 Feb	11229435
Characterization of a protease responsible for truncated actin increase in neutrophils of patients with Behçet's disease.	2001 Feb	11217076
Microwave decalcification of human temporal bones.	2001 Feb	11210875
Binding sites for progastrin-derived peptides in colonic crypts.	2001 Feb	11207897
Estimation of glomerular filtration rate in cancer patients.	2001 Feb	11207037
Localization of estrogen receptor beta protein expression in adult human bone.	2001 Feb	11204421
Simultaneous determination of 226Ra and 210Pb in groundwater and soil samples by using the liquid scintillation counter-suspension gel method.	2001 Feb	11200889
Pharmacological characterization and antithrombotic effect of agkistin, a platelet glycoprotein Ib antagonist.	2001 Feb	11181425
Determination of glomerular filtration rate per unit renal volume using computerized tomography: correlation with conventional measures of total and divided renal function.	2001 Feb	11176378
Influence of citrate and EDTA anticoagulants on plasma malondialdehyde concentrations estimated by high-performance liquid chromatography.	2001 Feb 10	11232851
Characterization of a model compound for the lysine tyrosylquinone cofactor of lysyl oxidase.	2001 Feb 16	11178979
Robustness of slope-intercept versus slope-only for measurement of glomerular filtration rate.	2001 Jan	11233546
Phagocytic response of bovine polymorphonuclear leukocytes to different incubation conditions and following exposure to some effectors of phagocytosis and different anticoagulants in vitro.	2001 Jan	11227193
Enhancement of jejunal absorption of conjugated bile acid by neurotensin in rats.	2001 Jan	11208724
Differential inhibitory mechanism of Fe2+ and Fe3+ on contraction of ileal longitudinal smooth muscle.	2001 Jan	11207072
Immunological assay for the determination of procarboxypeptidase U antigen levels in human plasma.	2001 Jan	11204563
Use of an orally administered combined sugar solution to evaluate intestinal absorption and permeability in cats.	2001 Jan	11197547
Flow cytometric analysis of the human articular chondrocyte phenotype in vitro.	2001 Jan	11178950
Long-term preservation of chilled canine semen: effect of commercial and laboratory prepared extenders.	2001 Jan 15	11233792
The occurrence of internal (1 --> 5)-linked arabinofuranose and arabinopyranose residues in arabinogalactan side chains from soybean pectic substances.	2001 Jan 15	11217953
Environmental lead exposure and progressive renal insufficiency.	2001 Jan 22	11176742
Determination of metal complexes of ethylenediaminetetraacetate in the presence of organic matter by high-performance liquid chromatography.	2001 Jan 5	11206782
Predicting the kinetics of peptide-antibody interactions using a multivariate experimental design of sequence and chemical space.	2001 Jan-Feb	11180562
Detection of bile duct leaks using MR cholangiography with mangfodipir trisodium (Teslascan).	2001 Jan-Feb	11176303
Measurement of intact insulin-like growth factor-binding protein-3 in human plasma using a ligand immunofunctional assay.	2001 Mar	11238518
Duration of sample storage dramatically alters expression of the human immunodeficiency virus coreceptors CXCR4 and CCR5.	2001 Mar	11238234
Adherence of Giardia lamblia trophozoites to Int-407 human intestinal cells.	2001 Mar	11238205
Pseudomonas aeruginosa protease IV enzyme assays and comparison to other Pseudomonas proteases.	2001 Mar	11237336
Kinetic modeling of liquid-phase adsorption of reactive dyes and metal ions on chitosan.	2001 Mar	11228956
Two new modes of smooth muscle myosin regulation by the interaction between the two regulatory light chains, and by the S2 domain.	2001 Mar	11226875
Quaternary ammoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells.	2001 Mar	11222522
Effect of collagenase inhibitors on corneal haze after PRK.	2001 Mar	11180974
Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors.	2001 Mar 15	11238657
EDTA redistribution of lead and cadmium into the soft tissues in a human with a high lead burden - should DMSA always be used to follow EDTA in such cases?	2011 Jun	21649453
Lead mobilization study and the clearance of intravenous CaNa2EDTA in a patient with end-stage renal failure on hemodialysis.	2012 Jan	21415282

Patents

Sample Use Guides

In Vivo Use Guide

hypercalcemia: adults: 50 mg/kg/day (up to 3 g/day) administered by slow IV infusion. Frequency and duration of administration are quite variable, and should be determined based on the patient's serum calcium. Five consecutive daily doses may be administered, followed by 2 days without medication, repeating these courses as necessary to a total of 15 doses.

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:37:08 GMT 2025` Edited by `admin` on `Mon Mar 31 17:37:08 GMT 2025`
Record UNII	9G34HU7RV0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EDTA	Locators: INCI MI VANDF Naming Organization: INCI Sources:

Preferred Name

English

Edetic Acid

Official Name

English

EDTA [VANDF]

Common Name

English

ETHYLENEDIAMINETETRAACETIC ACID

Systematic Name

English

EDETIC ACID [HSDB]

Common Name

English

Edetic acid [WHO-DD]

Common Name

English

edetic acid [INN]

Common Name

English

(Ethylenedinitrilo)tetraacetic acid

Systematic Name

English

EDETIC ACID [II]

Common Name

English

ANTICOAGULANT ETHYLENEDIAMINE TETRAACETIC ACID (EDTA)

Common Name

English

EDETIC ACID [MART.]

Common Name

English

EDTA [MI]

Common Name

English

EDETIC ACID [EP MONOGRAPH]

Common Name

English

VERSENE ACID

Brand Name

English

ANTICOAGULANT ETHYLENEDIAMINE TETRAACETIC ACID

Common Name

English

ETHYLENEBIS(IMINODIACETIC ACID)

Common Name

English

GLYCINE, N,N'-1,2-ETHANEDIYLBIS(N-(CARBOXYMETHYL)-

Systematic Name

English

EDETIC ACID [USP-RS]

Common Name

English

ETHYLENEDIAMINETETRAACETATE

Systematic Name

English

Classification Tree Code System Code

WHO-VATC

QV03AB03