EDETATE CALCIUM DISODIUM ANHYDROUS

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H12N2O8.Ca.2Na
Molecular Weight	374.268
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of EDETATE CALCIUM DISODIUM ANHYDROUS

Structure Search

SMILES

[Na+].[Na+].[Ca++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

InChIKey=SHWNNYZBHZIQQV-UHFFFAOYSA-J

InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4

HIDE SMILES / InChI

Molecular Formula	Ca
Molecular Weight	40.078
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C10H12N2O8
Molecular Weight	288.2109
Charge	-4
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/inactive/calcium-phosphate-dibasic-anhydrous-463.htmlhttp://apps.who.int/iris/bitstream/10665/43579/1/9789241530729_eng.pdfhttp://www.globalrph.com/calcium_supplements.htm | https://www.ncbi.nlm.nih.gov/pubmed/26265479
Curator's Comment: description was created based on several sources, including https://www.alfa.com/en/catalog/043674/

Calcium lactate is the salt that consists of two lactate anions for each calcium cation (Ca2+); this salt is used as a calcium supplement to treat hypocalcemia. However, as a source of free calcium, this salt is less convenient than calcium citrate. Calcium lactate inhalation powder also called as PUR118 participated in phase I clinical trials to determine whether this formulation was safe and tolerable in a population of subjects with Cystic Fibrosis (CF). PUR118 also was used in another clinical trials to evaluate its effect on ozone-induced airway Inflammation in healthy normal volunteers in case of Chronic Obstructive Pulmonary Disease (COPD). The obtained results revealed that PUR118 reduced the severity of acute exacerbations in COPD and CF and had the beneficial impacts on mortality, morbidity, and quality of life in affected individuals. However, both studies were discontinued.

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2596
Hypocalcemia 73 Sources: http://www.globalrph.com/calcium_supplements.htm	Primary	Not Provided 511	Unknown Approved Use Unknown
Chronic obstructive pulmonary disease 175 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26265479	Palliative	Phase I 438	Unknown Approved Use Unknown
Cystic fibrosis 120 Sources: https://clinicaltrials.gov/ct2/show/NCT01543191	Palliative	Phase I 438	Unknown Approved Use Unknown
Unknown 2596
Hypocalcemia 73 Sources: https://www.drugs.com/mmx/calcium-phosphate-dibasic.html	Primary	Approved 8583	Unknown Approved Use Hypocalcemia, chronic (treatment) — Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency, oral calcium salts may be administered concomitantly with vitamin D analogs. However, calcium phosphate should not be used in patients with hypoparathyroidism or renal failure, since phosphate levels may be too high and giving more phosphate would exacerbate the condition. Calcium supplements should not be used in hyperparathyroidism, unless the need for a calcium supplement is high and the patient is carefully monitored. For treatment of hypocalcemia, supplementation is preferred

PubMed

Title	Date	PubMed
Dietary interventions for mineral and bone disorder in people with chronic kidney disease.	2015-09-16	26376110
Long-term remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo: a systematic review.	2014-07	24705069
Effect of calcium phosphate and vitamin D₃ supplementation on bone remodelling and metabolism of calcium, phosphorus, magnesium and iron.	2014-01-17	24438153
A combination of calcium phosphate and probiotics beneficially influences intestinal lactobacilli and cholesterol metabolism in humans.	2012-04	22019281
Dietary calcium source influences body composition, glucose metabolism and hormone levels in a mouse model of postmenopausal obesity.	2009-07-02	19567386
Henri Moissan: winner of the Nobel Prize for Chemistry 1906.	2006-10-20	16960820
[Prevention of osteoporosis by foods and dietary supplements. Bioavailability of milk micellar calcium phosphate].	2006-10	17012812
Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension.	2003-01	12388232
Interaction of intravenous anesthetics with recombinant human M1-M3 muscarinic receptors expressed in chinese hamster ovary cells.	2002-12	12456425
Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons.	2002-11-04	12445469
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.	2002-09-15	12069687
Effects of endothelin B receptor agonists on amyloid beta protein (25-35)-induced neuronal cell death.	2002-09-06	12383957
A critical interplay between Ca2+ inhibition and activation by Mg2+ of AC5 revealed by mutants and chimeric constructs.	2002-09-06	12065575
Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.	2002-09	12181424
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.	2002-07-05	11959854
Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones.	2002-07	12110441
Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intravenous calcium.	2002-07	12101159
Expression of functional CCR and CXCR chemokine receptors in podocytes.	2002-06-15	12055238
Human kidney diamine oxidase: heterologous expression, purification, and characterization.	2002-06	12072962
Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.	2002-05-15	11988098
The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells.	2002-04-19	11830588
Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	2002-03-15	11897840
Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.	2002-03	11895442
Hypertension-related intermyocyte junction remodelling is associated with a higher incidence of low-K(+)-induced lethal arrhythmias in isolated rat heart.	2002-03	11856964
Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.	2002-02-01	11826162
CXCR4 expression on monocytes is up-regulated by dexamethasone and is modulated by autologous CD3+ T cells.	2002-02	11872090
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.	2002-02	11796525
Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.	2002-01-15	11809688
Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats.	2002	12421626
Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds.	2001-12-21	11592964
Complement activation in factor D-deficient mice.	2001-12-04	11724962
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.	2001-11-30	11577072
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.	2001-11-01	11705452
Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities.	2001-11	11701772
Activating mutations of the calcium-sensing receptor: management of hypocalcemia.	2001-11	11701698
Regression of ventral striatum hypometabolism after calcium/calcitriol therapy in paroxysmal kinesigenic choreoathetosis due to idiopathic primary hypoparathyroidism.	2001-11	11606688
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.	2001-10-26	11679415
Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2+) channels.	2001-10-12	11597992
Microarray analysis of differential gene expression in lead-exposed astrocytes.	2001-10-01	11578147
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.	2001-10	11606325
Familial intrahepatic cholestasis 1: studies of localization and function.	2001-10	11584374
A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein.	2001-09-15	11535132
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.	2001-09-07	11553362
Heterologous expression of the Na(+),K(+)-ATPase gamma subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore.	2001-09-01	11533133
Regional differences in functional receptor distribution and calcium mobilization in the intact human lens.	2001-09	11527950
Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism.	2001-09	11500311
Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity.	2001-08-28	11513607
Endothelin-induced changes of secondary messengers in cultured corneal endothelial cells.	2001-08	11572466
[Acute renal failure caused by hypercalcemia].	2001-06-10	11464680
Studies on the calcemic effect of intravenous secretin in humans.	1975-06	1220513

Patents

Sample Use Guides

In Vivo Use Guide

Proper administration of calcium carbonate or phosphate: Taking tablets 1 to 11/2 hours after meals, unless otherwise directed by physician. Recommended doses for adolescents and adults is 800-1200 mg/day; for pregnat orbreast-feeding females 1200 mg/day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:59:08 GMT 2025` Edited by `admin` on `Mon Mar 31 17:59:08 GMT 2025`
Record UNII	8U5D034955
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CALCIUM DISODIUM EDTA

Preferred Name

English

EDETATE CALCIUM DISODIUM ANHYDROUS

Common Name

English

SODIUM CALCIUM EDETATE

Official Name

English

CALCIATE (2-), ((N,N'-1,2-ETHANEDIYLBIS(N-(CARBOXYMETHYL)GLYCINATO))(4-)-N,N',O,O',ON,ON')-, DISODIUM

Common Name

English

INS-385

Code

English

CALCIATE(2-), ((N,N'-1,2-ETHANEDIYLBIS(N-((CARBOXY- .KAPPA.O)METHYL)GLYCINATO-.KAPPA.N,.KAPPA.O))(4-))-, DISODIUM, (OC-6-21)-

Common Name

English

ETHYLENE DIAMINE TETRAACETIC ACID, DISODIUM CALCIUM SALT

Common Name

English

CALCIUM DISODIUM EDETATE

Systematic Name

English

CALCIUM TITRIPLEX

Common Name

English

CALCIUM DISODIUM ETHYLENE-DIAMINETETRAACETATE

Systematic Name

English

CALCIUM DISODIUM ETHYLENEDIAMINETETRAACETATE

Systematic Name

English

E-385

Code

English

CALCIATE(2-), ((ETHYLENEDINITRILO)TETRAACETATO)-, DISODIUM

Common Name

English

INS NO.385

Code

English

DETOXAMIN

Common Name

English

CALCIUM DISODIUM (ETHYLENEDINITRILO)TETRAACETATE

Systematic Name

English

DISODIUM CALCIUM EDTA

Common Name

English

SODIUM CALCIUM EDETATE [EP MONOGRAPH]

Common Name

English

TETAZINE

Common Name

English

Sodium calcium edetate [WHO-DD]

Common Name

English

CALCIATE(2-), ((N,N'-1,2-ETHANEDIYLBIS(N-((CARBOXY- .KAPPA.O)METHYL)GLYCINATO-.KAPPA.N,.KAPPA.O))(4-))-, SODIUM (1:2), (OC-6-21)-

Common Name

English

DISODIUM((ETHYLENEDINITRILO)TETRAACETATO)CALCIATE(2-)

Common Name

English

CALCIATE (2-), ((N,N'-1,2-ETHANEDIYLBIS(N-(CARBOXYMETHYL)GLYCINATO))(4-)-N,N',O,O',ON,ON')-, DISODIUM, (OC-6-21)-

Common Name

English

NSC-310151

Code

English

EDETATE CALCIUM DISODIUM (ANHYDROUS) [HSDB]

Common Name

English

EDTA CALCIUM DISODIUM SALT [MI]

Common Name

English

CALCIUM DISODIUM EDETATE [GREEN BOOK]

Common Name

English

sodium calcium edetate [INN]

Common Name

English

EDETAMINE

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 176.170