U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Ca
Molecular Weight 40.078
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of CALCIUM CATION

SMILES

[Ca++]

InChI

InChIKey=BHPQYMZQTOCNFJ-UHFFFAOYSA-N
InChI=1S/Ca/q+2

HIDE SMILES / InChI

Molecular Formula Ca
Molecular Weight 40.078
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Calcium iodide (chemical formula CaI2) is the ionic compound of calcium and iodine, used in cat food as a source of iodine This colourless deliquescent solid is a salt that is highly soluble in water. Calcium iodide properties are similar to those for related salts, such as calcium chloride. Calcium iodide is also used in photography.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Hypocalcemia, chronic (treatment) — Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency, oral calcium salts may be administered concomitantly with vitamin D analogs. However, calcium phosphate should not be used in patients with hypoparathyroidism or renal failure, since phosphate levels may be too high and giving more phosphate would exacerbate the condition. Calcium supplements should not be used in hyperparathyroidism, unless the need for a calcium supplement is high and the patient is carefully monitored. For treatment of hypocalcemia, supplementation is preferred
PubMed

PubMed

TitleDatePubMed
Endothelin-induced changes of secondary messengers in cultured corneal endothelial cells.
2001 Aug
Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity.
2001 Aug 28
Complement activation in factor D-deficient mice.
2001 Dec 4
Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line.
2001 Jul
Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine.
2001 Jul
Endothelin- and sarafotoxin-induced receptor-mediated calcium mobilization in a clonal murine osteoblast-like cell line, MC3T3-E1/B.
2001 Jun
[Acute renal failure caused by hypercalcemia].
2001 Jun 10
Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy.
2001 Jun 8
Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities.
2001 Nov
Activating mutations of the calcium-sensing receptor: management of hypocalcemia.
2001 Nov
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.
2001 Nov 1
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.
2001 Nov 30
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
2001 Oct
Familial intrahepatic cholestasis 1: studies of localization and function.
2001 Oct
Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2+) channels.
2001 Oct 12
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.
2001 Oct 26
Heterologous expression of the Na(+),K(+)-ATPase gamma subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore.
2001 Sep 1
A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein.
2001 Sep 15
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.
2001 Sep 7
Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats.
2002
The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells.
2002 Apr 19
Interaction of intravenous anesthetics with recombinant human M1-M3 muscarinic receptors expressed in chinese hamster ovary cells.
2002 Dec
CXCR4 expression on monocytes is up-regulated by dexamethasone and is modulated by autologous CD3+ T cells.
2002 Feb
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.
2002 Feb
Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.
2002 Feb 1
Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.
2002 Jan 15
Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones.
2002 Jul
Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intravenous calcium.
2002 Jul
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.
2002 Jul 5
Human kidney diamine oxidase: heterologous expression, purification, and characterization.
2002 Jun
Expression of functional CCR and CXCR chemokine receptors in podocytes.
2002 Jun 15
Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.
2002 Mar
Hypertension-related intermyocyte junction remodelling is associated with a higher incidence of low-K(+)-induced lethal arrhythmias in isolated rat heart.
2002 Mar
Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.
2002 Mar 15
Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.
2002 May 15
Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons.
2002 Nov 4
Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.
2002 Sep
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.
2002 Sep 15
Effects of endothelin B receptor agonists on amyloid beta protein (25-35)-induced neuronal cell death.
2002 Sep 6
Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension.
2003 Jan
[Prevention of osteoporosis by foods and dietary supplements. Bioavailability of milk micellar calcium phosphate].
2006 Oct
Henri Moissan: winner of the Nobel Prize for Chemistry 1906.
2006 Oct 20
Dietary calcium source influences body composition, glucose metabolism and hormone levels in a mouse model of postmenopausal obesity.
2009 Jul-Aug
A combination of calcium phosphate and probiotics beneficially influences intestinal lactobacilli and cholesterol metabolism in humans.
2012 Apr
Effect of calcium phosphate and vitamin D₃ supplementation on bone remodelling and metabolism of calcium, phosphorus, magnesium and iron.
2014 Jan 17
Long-term remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo: a systematic review.
2014 Jul
Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model--a clinical trial.
2015 Aug 12
Dietary interventions for mineral and bone disorder in people with chronic kidney disease.
2015 Sep 16
Lactose behaviour in the presence of lactic acid and calcium.
2016 Aug
Effects of ultrasound treatment on physico-chemical, functional properties and antioxidant activity of whey protein isolate in the presence of calcium lactate.
2018 Mar
Patents

Sample Use Guides

oral: 500 to 2000 mg elemental calcium a day, in divided doses (bid-qid). inhalation: In a single-blind, phase 1B proof of concept study, 24 subjects were enrolled to sequentially receive three doses of PUR118 (calcium lactate inhalation powder (CLIP) formulation) (5.5 mg, n = 18; 11.0 mg, n = 18; 2.8 mg, n = 16). Each dose was inhaled 3 times (1, 13, 25 h, preceded by 2 puffs salbutamol) before the ozone exposure (250 ppb, 3 h intermittent exercise). Sputum was induced 3 h after the end of exposure.
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 16 18:01:17 UTC 2022
Edited
by admin
on Fri Dec 16 18:01:17 UTC 2022
Record UNII
2M83C4R6ZB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CALCIUM CATION
Common Name English
CALCIUM(2+)
Systematic Name English
CA2+
Common Name English
CALCIUM (II) ION
Common Name English
CALCIUM(2+) ION
Common Name English
CALCIUM ION(2+)
Common Name English
CALCIUM, ION(CA2+)
Common Name English
CALCIUM ION
Common Name English
Classification Tree Code System Code
LOINC 13959-2
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LOINC 53087-3
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LOINC 83064-6
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WHO-ATC A12AA07
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NCI_THESAURUS C68241
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LOINC 49936-8
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LOINC 53139-2
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LOINC 50837-4
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LOINC 59472-1
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LOINC 17863-2
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LOINC 12180-6
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NDF-RT N0000184168
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LOINC 14415-4
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WHO-ATC A12AA20
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NCI_THESAURUS C597
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LOINC 41645-3
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LOINC 57333-7
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LOINC 17864-0
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LOINC 38230-9
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LOINC 34581-9
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LOINC 46093-1
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LOINC 41644-6
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LOINC 47596-2
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LOINC 49935-0
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LOINC 54367-8
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LOINC 53138-4
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LOINC 53140-0
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LOINC 59470-5
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LOINC 42567-8
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LOINC 54366-0
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LOINC 59471-3
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LOINC 53088-1
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LOINC 1994-3
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LOINC 47598-8
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LOINC 1995-0
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LOINC 59473-9
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LOINC 50838-2
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LOINC 41646-1
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LOINC 19072-8
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Code System Code Type Description
CHEBI
39123
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY
NDF-RT
N0000009252
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY Increased Coagulation Factor Activity [PE]
DAILYMED
2M83C4R6ZB
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY
FDA UNII
2M83C4R6ZB
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY
CHEBI
39099
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY
EPA CompTox
DTXSID7037638
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY
EVMPD
SUB121174
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY
CHEBI
29108
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY
DRUG BANK
DB14577
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY
NDF-RT
N0000166192
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY Cations, Divalent [Chemical/Ingredient]
CHEBI
39124
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY
NCI_THESAURUS
C61660
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY
RXCUI
1316581
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY RxNorm
CAS
14127-61-8
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY
PUBCHEM
271
Created by admin on Fri Dec 16 18:01:18 UTC 2022 , Edited by admin on Fri Dec 16 18:01:18 UTC 2022
PRIMARY
Related Record Type Details
ACTIVE MOIETY