U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Ca
Molecular Weight 40.078
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of CALCIUM CATION

SMILES

[Ca++]

InChI

InChIKey=BHPQYMZQTOCNFJ-UHFFFAOYSA-N
InChI=1S/Ca/q+2

HIDE SMILES / InChI

Molecular Formula Ca
Molecular Weight 40.078
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260884.htm | http://www.webmd.com/drugs/2/drug-159847/calcium-phosphate-dibasic-oral/details

Anhydrous dibasic calcium phosphate is a calcium salt of phosphoric acid. It is used as a diluent in pharmaceutical industry, in some toothpastes as a polishing agent. Calcium phosphate is generally recognized as safe by FDA. Dibasic calcium phosphate is ised as a supplement to treat conditions associated with calcium deficit, such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany)

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Hypocalcemia, chronic (treatment) — Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency, oral calcium salts may be administered concomitantly with vitamin D analogs. However, calcium phosphate should not be used in patients with hypoparathyroidism or renal failure, since phosphate levels may be too high and giving more phosphate would exacerbate the condition. Calcium supplements should not be used in hyperparathyroidism, unless the need for a calcium supplement is high and the patient is carefully monitored. For treatment of hypocalcemia, supplementation is preferred
PubMed

PubMed

TitleDatePubMed
[Early stage of cardiomyopathy: mechanisms of damage and compensation].
1999 Jul
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.
1999 Sep
C-reactive protein in the hemolymph of Achatina fulica: interrelationship with sex steroids and metallothionein.
2000 Apr
Oim mice exhibit altered femur and incisor mineral composition and decreased bone mineral density.
2000 Aug
Regulation of Na/K-ATPase beta1-subunit gene expression by ouabain and other hypertrophic stimuli in neonatal rat cardiac myocytes.
2000 Dec
D2 dopamine receptors in striatal medium spiny neurons reduce L-type Ca2+ currents and excitability via a novel PLC[beta]1-IP3-calcineurin-signaling cascade.
2000 Dec 15
Inactivation properties of human recombinant class E calcium channels.
2000 Feb
Regulation of LPA-promoted myofibroblast contraction: role of Rho, myosin light chain kinase, and myosin light chain phosphatase.
2000 Feb 1
Effect of ADP and ionic strength on the kinetic and motile properties of recombinant mouse myosin V.
2000 Feb 11
Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors.
2000 Feb 15
alpha(1E) subunits form the pore of three cerebellar R-type calcium channels with different pharmacological and permeation properties.
2000 Jan 1
Vanadate induces calcium signaling, Ca2+ release-activated Ca2+ channel activation, and gene expression in T lymphocytes and RBL-2H3 mast cells via thiol oxidation.
2000 Jan 15
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.
2000 Jan 7
Hepatocyte growth factor disrupts cell contact and stimulates an increase in type 3 inositol triphosphate receptor expression, intracellular calcium levels, and apoptosis of rat ovarian surface epithelial cells.
2000 Jun
A family of gamma-like calcium channel subunits.
2000 Mar 24
Polyoxygenated dysidea sterols that inhibit the binding of [I125] IL-8 to the human recombinant IL-8 receptor type A.
2000 May
Dual regulation of leptin secretion: intracellular energy and calcium dependence of regulated pathway.
2000 May
Ca2+-induced contraction of cat esophageal circular smooth muscle cells.
2001 Apr
Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity.
2001 Apr 27
Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations.
2001 Apr 7
Endothelin-induced changes of secondary messengers in cultured corneal endothelial cells.
2001 Aug
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel.
2001 Feb 16
Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line.
2001 Jul
Analysis of the native quaternary structure of vanilloid receptor 1.
2001 Jul 27
Mechanisms of regulation of agonist efficacy at the 5-HT(1A) receptor by phospholipid-derived signaling components.
2001 Jun
Vasopressin-stimulated Ca2+ spiking in vascular smooth muscle cells involves phospholipase D.
2001 Jun
[Acute renal failure caused by hypercalcemia].
2001 Jun 10
Cloning and characterization of a novel human histamine receptor.
2001 Mar
Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines.
2001 Mar
Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors.
2001 Mar 15
Tight control of exogenous SERCA expression is required to obtain acceleration of calcium transients with minimal cytotoxic effects in cardiac myocytes.
2001 Mar 2
RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses.
2001 Mar 27
Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities.
2001 Nov
Activating mutations of the calcium-sensing receptor: management of hypocalcemia.
2001 Nov
Regression of ventral striatum hypometabolism after calcium/calcitriol therapy in paroxysmal kinesigenic choreoathetosis due to idiopathic primary hypoparathyroidism.
2001 Nov
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.
2001 Nov 1
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.
2001 Nov 30
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
2001 Oct
Microarray analysis of differential gene expression in lead-exposed astrocytes.
2001 Oct 1
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.
2001 Oct 26
Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats.
2002
Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.
2002 Feb 1
Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.
2002 Jan 15
Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones.
2002 Jul
Expression of functional CCR and CXCR chemokine receptors in podocytes.
2002 Jun 15
Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.
2002 Mar
Hypertension-related intermyocyte junction remodelling is associated with a higher incidence of low-K(+)-induced lethal arrhythmias in isolated rat heart.
2002 Mar
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.
2002 Sep 15
Effects of endothelin B receptor agonists on amyloid beta protein (25-35)-induced neuronal cell death.
2002 Sep 6
Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension.
2003 Jan
Patents

Sample Use Guides

oral: 500 to 2000 mg elemental calcium a day, in divided doses (bid-qid). inhalation: In a single-blind, phase 1B proof of concept study, 24 subjects were enrolled to sequentially receive three doses of PUR118 (calcium lactate inhalation powder (CLIP) formulation) (5.5 mg, n = 18; 11.0 mg, n = 18; 2.8 mg, n = 16). Each dose was inhaled 3 times (1, 13, 25 h, preceded by 2 puffs salbutamol) before the ozone exposure (250 ppb, 3 h intermittent exercise). Sputum was induced 3 h after the end of exposure.
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:44:14 GMT 2023
Edited
by admin
on Fri Dec 15 15:44:14 GMT 2023
Record UNII
2M83C4R6ZB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CALCIUM CATION
Common Name English
CALCIUM(2+)
Systematic Name English
CA2+
Common Name English
CALCIUM (II) ION
Common Name English
CALCIUM(2+) ION
Common Name English
CALCIUM ION(2+)
Common Name English
CALCIUM, ION(CA2+)
Common Name English
CALCIUM ION
Common Name English
Classification Tree Code System Code
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WHO-ATC A12AA07
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NCI_THESAURUS C68241
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NDF-RT N0000184168
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NCI_THESAURUS C597
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Code System Code Type Description
CHEBI
39123
Created by admin on Fri Dec 15 15:44:15 GMT 2023 , Edited by admin on Fri Dec 15 15:44:15 GMT 2023
PRIMARY
NDF-RT
N0000009252
Created by admin on Fri Dec 15 15:44:15 GMT 2023 , Edited by admin on Fri Dec 15 15:44:15 GMT 2023
PRIMARY Increased Coagulation Factor Activity [PE]
DAILYMED
2M83C4R6ZB
Created by admin on Fri Dec 15 15:44:15 GMT 2023 , Edited by admin on Fri Dec 15 15:44:15 GMT 2023
PRIMARY
FDA UNII
2M83C4R6ZB
Created by admin on Fri Dec 15 15:44:15 GMT 2023 , Edited by admin on Fri Dec 15 15:44:15 GMT 2023
PRIMARY
CHEBI
39099
Created by admin on Fri Dec 15 15:44:15 GMT 2023 , Edited by admin on Fri Dec 15 15:44:15 GMT 2023
PRIMARY
EPA CompTox
DTXSID7037638
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PRIMARY
EVMPD
SUB121174
Created by admin on Fri Dec 15 15:44:15 GMT 2023 , Edited by admin on Fri Dec 15 15:44:15 GMT 2023
PRIMARY
CHEBI
29108
Created by admin on Fri Dec 15 15:44:15 GMT 2023 , Edited by admin on Fri Dec 15 15:44:15 GMT 2023
PRIMARY
DRUG BANK
DB14577
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PRIMARY
SMS_ID
100000144534
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PRIMARY
NDF-RT
N0000166192
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PRIMARY Cations, Divalent [Chemical/Ingredient]
CHEBI
39124
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PRIMARY
NCI_THESAURUS
C61660
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PRIMARY
RXCUI
1316581
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PRIMARY RxNorm
CAS
14127-61-8
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PRIMARY
PUBCHEM
271
Created by admin on Fri Dec 15 15:44:15 GMT 2023 , Edited by admin on Fri Dec 15 15:44:15 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY