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Details

Stereochemistry ACHIRAL
Molecular Formula Ca
Molecular Weight 40.078
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of CALCIUM CATION

SMILES

[Ca++]

InChI

InChIKey=BHPQYMZQTOCNFJ-UHFFFAOYSA-N
InChI=1S/Ca/q+2

HIDE SMILES / InChI

Molecular Formula Ca
Molecular Weight 40.078
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Calcium lactate is the salt that consists of two lactate anions for each calcium cation (Ca2+); this salt is used as a calcium supplement to treat hypocalcemia. However, as a source of free calcium, this salt is less convenient than calcium citrate. Calcium lactate inhalation powder also called as PUR118 participated in phase I clinical trials to determine whether this formulation was safe and tolerable in a population of subjects with Cystic Fibrosis (CF). PUR118 also was used in another clinical trials to evaluate its effect on ozone-induced airway Inflammation in healthy normal volunteers in case of Chronic Obstructive Pulmonary Disease (COPD). The obtained results revealed that PUR118 reduced the severity of acute exacerbations in COPD and CF and had the beneficial impacts on mortality, morbidity, and quality of life in affected individuals. However, both studies were discontinued.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Hypocalcemia, chronic (treatment) — Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency, oral calcium salts may be administered concomitantly with vitamin D analogs. However, calcium phosphate should not be used in patients with hypoparathyroidism or renal failure, since phosphate levels may be too high and giving more phosphate would exacerbate the condition. Calcium supplements should not be used in hyperparathyroidism, unless the need for a calcium supplement is high and the patient is carefully monitored. For treatment of hypocalcemia, supplementation is preferred
PubMed

PubMed

TitleDatePubMed
Studies on the calcemic effect of intravenous secretin in humans.
1975 Jun
1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes.
1999 Feb
Aluminum is a weak agonist for the calcium-sensing receptor.
1999 May
Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes.
1999 Sep
Oim mice exhibit altered femur and incisor mineral composition and decreased bone mineral density.
2000 Aug
Regulation of LPA-promoted myofibroblast contraction: role of Rho, myosin light chain kinase, and myosin light chain phosphatase.
2000 Feb 1
alpha(1E) subunits form the pore of three cerebellar R-type calcium channels with different pharmacological and permeation properties.
2000 Jan 1
Vanadate induces calcium signaling, Ca2+ release-activated Ca2+ channel activation, and gene expression in T lymphocytes and RBL-2H3 mast cells via thiol oxidation.
2000 Jan 15
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.
2000 Jan 7
NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways.
2000 Jul 17
Chemokines induce eosinophil degranulation through CCR-3.
2000 Sep
Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds.
2001 Dec 21
Complement activation in factor D-deficient mice.
2001 Dec 4
Molecular and functional characterization of a family of rat brain T-type calcium channels.
2001 Feb 9
Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line.
2001 Jul
Mechanisms of regulation of agonist efficacy at the 5-HT(1A) receptor by phospholipid-derived signaling components.
2001 Jun
[Acute renal failure caused by hypercalcemia].
2001 Jun 10
Cloning and characterization of a novel human histamine receptor.
2001 Mar
Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines.
2001 Mar
RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses.
2001 Mar 27
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.
2001 Nov 1
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
2001 Oct
Microarray analysis of differential gene expression in lead-exposed astrocytes.
2001 Oct 1
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.
2001 Oct 26
Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism.
2001 Sep
Interaction of intravenous anesthetics with recombinant human M1-M3 muscarinic receptors expressed in chinese hamster ovary cells.
2002 Dec
CXCR4 expression on monocytes is up-regulated by dexamethasone and is modulated by autologous CD3+ T cells.
2002 Feb
Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.
2002 Jan 15
Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones.
2002 Jul
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.
2002 Jul 5
Hypertension-related intermyocyte junction remodelling is associated with a higher incidence of low-K(+)-induced lethal arrhythmias in isolated rat heart.
2002 Mar
Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.
2002 Mar 15
Long-term remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo: a systematic review.
2014 Jul
Lactose behaviour in the presence of lactic acid and calcium.
2016 Aug
Patents

Sample Use Guides

Proper administration of calcium carbonate or phosphate: Taking tablets 1 to 11/2 hours after meals, unless otherwise directed by physician. Recommended doses for adolescents and adults is 800-1200 mg/day; for pregnat orbreast-feeding females 1200 mg/day.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:12:57 UTC 2023
Edited
by admin
on Wed Jul 05 23:12:57 UTC 2023
Record UNII
2M83C4R6ZB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CALCIUM CATION
Common Name English
CALCIUM(2+)
Systematic Name English
CA2+
Common Name English
CALCIUM (II) ION
Common Name English
CALCIUM(2+) ION
Common Name English
CALCIUM ION(2+)
Common Name English
CALCIUM, ION(CA2+)
Common Name English
CALCIUM ION
Common Name English
Classification Tree Code System Code
LOINC 13959-2
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
LOINC 53087-3
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LOINC 83064-6
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WHO-ATC A12AA07
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
NCI_THESAURUS C68241
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
LOINC 49936-8
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
LOINC 53139-2
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LOINC 50837-4
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LOINC 59472-1
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LOINC 17863-2
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LOINC 12180-6
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NDF-RT N0000184168
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LOINC 14415-4
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WHO-ATC A12AA20
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
NCI_THESAURUS C597
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
LOINC 41645-3
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LOINC 57333-7
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LOINC 17864-0
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LOINC 38230-9
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LOINC 34581-9
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LOINC 46093-1
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LOINC 41644-6
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LOINC 47596-2
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LOINC 49935-0
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LOINC 54367-8
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LOINC 53138-4
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LOINC 53140-0
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LOINC 59470-5
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LOINC 42567-8
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LOINC 54366-0
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LOINC 59471-3
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LOINC 53088-1
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LOINC 1994-3
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LOINC 47598-8
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LOINC 1995-0
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LOINC 59473-9
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
LOINC 50838-2
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
LOINC 41646-1
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
LOINC 19072-8
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
Code System Code Type Description
CHEBI
39123
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
NDF-RT
N0000009252
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY Increased Coagulation Factor Activity [PE]
DAILYMED
2M83C4R6ZB
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
FDA UNII
2M83C4R6ZB
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
CHEBI
39099
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
EPA CompTox
DTXSID7037638
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
EVMPD
SUB121174
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
CHEBI
29108
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
DRUG BANK
DB14577
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
SMS_ID
100000144534
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
NDF-RT
N0000166192
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY Cations, Divalent [Chemical/Ingredient]
CHEBI
39124
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
NCI_THESAURUS
C61660
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
RXCUI
1316581
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY RxNorm
CAS
14127-61-8
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
PUBCHEM
271
Created by admin on Wed Jul 05 23:12:58 UTC 2023 , Edited by admin on Wed Jul 05 23:12:58 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY