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Details

Stereochemistry ACHIRAL
Molecular Formula C10H12N2O8.2Co
Molecular Weight 406.0773
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DICOBALT EDETATE

SMILES

[Co++].[Co++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

InChIKey=TWAWHTJKASJPEK-UHFFFAOYSA-J
InChI=1S/C10H16N2O8.2Co/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;2*+2/p-4

HIDE SMILES / InChI
Molecular Formula C10H12N2O8
Molecular Weight 288.2109
Charge -4
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Co
Molecular Weight 58.9332
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: https://www.ncbi.nlm.nih.gov/pubmed/6787340 | https://www.drugs.com/uk/dicobalt-edetate-injection-300mg-leaflet.html

Cobalt Disodium Edetate (Cobalt EDTA) is a derivative of Ethylenediamine Tetraacetic Acid. Ethylenediamine Tetraacetic Acid is a Sequestering / Chelating Agent. Cobalt EDTA is a Sequestering Agent, which is normally used in Agriculture and Veterinary application for correcting Cobalt deficiency. Cobalt Disodium Edetate (Cobalt disodium ethylenediamine tetraacetate, Copoietin A) appears to represent the most satisfactory type of Cobalt-containing hemopoietic agents tested and should be worthy of clinical trial as a therapeutic agent for the treatment of anemia.

CNS Activity

Originator

Münz, F.
3
Curator's Comment: The first use of cobalt compounds as cyanide antagonists was advocated by Antal J. in 1894. http://www.firesmoke.org/wp-content/uploads/2010/10/Cyanide_As_A_Weapon.pdf

Approval Year

1963
70
Targets

Targets

Primary TargetPharmacologyConditionPotency
Chelating Agent
142
Fructose-bisphosphate aldolase B
2
Target ID: P79226
Gene ID: 1.00328928E8
Gene Symbol: ALDOB
Target Organism: Oryctolagus cuniculus (Rabbit)
Activator
1430
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
SWITCH C Hi Mineral

Approved Use

Recommended use: Low dose oral drench for the treatment and control of internal parasites in cattle
Primary
Preclinical
Unknown

Approved Use

Unknown
Curative
Approved
8429
KELOCYANOR

Approved Use

Dicobalt Edetate Injection is a specific antidote for acute cyanide poisoning. In view of the difficulty of certain diagnosis in emergency situations, it is recommended that Dicobalt Edetate Injection only be given when the patient is tending to lose or has lost consciousness.
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
9.8 μg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/25414476/
4.28 mg/kg single, intravenous
dose: 4.28 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
COBALT plasma
Sus scrofa
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
518 μg × min/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/25414476/
4.28 mg/kg single, intravenous
dose: 4.28 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
COBALT plasma
Sus scrofa
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
136 min
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/25414476/
4.28 mg/kg single, intravenous
dose: 4.28 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
COBALT plasma
Sus scrofa
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
Sourcing

Sourcing

Vendor/AggregatorIDURL
ABI Chem
AC1L2H44
AHH Chemical co.,ltd
MT-49463
http://www.ahhchemical.com/product/MT-49463.html
Ambinter
Amb22899123
http://www.ambinter.com/reference/22899123
BLD Pharm
BD124404
http://www.bldpharm.com/products/36499-65-7.html
ChemMol
99074893
http://www.chemmol.com/chemmol/99074893.html
ChemTik
CTK5I5019
MP Biomedicals
212205
Molcore
MC551306
https://www.molcore.com/product/36499-65-7
MuseChem
R015173
https://www.musechem.com/product/R015173.html
NovoSeek
71942
PubChem
71942
https://pubchem.ncbi.nlm.nih.gov/compound/71942
Smolecule
S525974
http://www.smolecule.com/products/s525974
THE BioTek
bt-264458
https://www.thebiotek.com/product/inhibitors/bt-264458
eNovation Chemicals
D670689
https://www.enovationchem.com/ProductDetails.asp?ProductID=D670689
PubMed

PubMed

TitleDatePubMed
Activation of rabbit kidney fructose diphosphatase by Mg-EDTA, Mn-EDTA and Co-EDTA complexes.
1973 Jan
Ruminal infusions of cobalt-EDTA reduce mammary delta9-desaturase index and alter milk fatty acid composition in lactating cows.
2008 Apr
Cobalt-induced changes in the spleen of mice from different stages of development.
2012
Evaluation of the double-disk synergy test for New Delhi metallo-β-lactamase-1 and other metallo-β-lactamase producing gram-negative bacteria by using metal-ethylenediaminetetraacetic acid complexes.
2013 May
Separation of digesta fractions complicates estimation of ileal digestibility using marker methods with Cr2O3 and cobalt-ethylenediamine tetraacetic acid in broiler chickens.
2014 Aug
Patents

Patents

US20030082107
2
US20090117207
2

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Also was used orally in rats: Cobalt disodium ethylenediamine tetra-acetate in a dosage of 4, 8, 10, 20, 40 mg/Kg of elemental cobalt had no effect on the weight gain of weanling rats.
600 mg (20 ml) in 30 seconds followed by an intravenous injection of 50 ml of hypertonic glucose solution.
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:04:50 UTC 2023
Edited
by admin
on Fri Dec 15 16:04:50 UTC 2023
Record UNII
UKC6GH80QR
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DICOBALT EDETATE
INN   MART.   WHO-DD  
INN  
Official Name English
DICOBALT ETHYLENEDIAMINETETRAACETATE
Systematic Name English
Dicobalt edetate [WHO-DD]
Common Name English
dicobalt edetate [INN]
Common Name English
COBALT(2+)((ETHYLENEDINITRILO)TETRAACETATO)COBALTATE(2-)
Common Name English
KELOCYANOR
Brand Name English
EDTA COBALT SALT [MI]
Common Name English
DICOBALT EDETATE [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C26170
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C81167
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
PRIMARY
WIKIPEDIA
DICOBALT EDETATE
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
PRIMARY
ECHA (EC/EINECS)
253-067-5
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
PRIMARY
RXCUI
288331
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
PRIMARY RxNorm
INN
4989
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
PRIMARY
PUBCHEM
71942
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
PRIMARY
MERCK INDEX
m4835
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
PRIMARY Merck Index
EVMPD
SUB13569MIG
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
PRIMARY
SMS_ID
100000079552
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
PRIMARY
FDA UNII
UKC6GH80QR
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
PRIMARY
EPA CompTox
DTXSID70189997
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
PRIMARY
CAS
36499-65-7
Created by admin on Fri Dec 15 16:04:50 UTC 2023 , Edited by admin on Fri Dec 15 16:04:50 UTC 2023
PRIMARY
Related Record Type Details
Structure of EDETIC ACID
PARENT -> SALT/SOLVATE
Structure of COBALTOUS CATION
PARENT -> SALT/SOLVATE
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