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Details

Stereochemistry ACHIRAL
Molecular Formula Co
Molecular Weight 58.9332
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of COBALTOUS CATION

SMILES

[Co++]

InChI

InChIKey=XLJKHNWPARRRJB-UHFFFAOYSA-N
InChI=1S/Co/q+2

HIDE SMILES / InChI

Molecular Formula Co
Molecular Weight 58.9332
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Cobalt is a transition metal, naturally ocurring in the minerals cobaltite, smaltite, and erythrite, and is often associated with nickel, silver, lead, copper, and iron ores, from which it is most frequently obtained as a by-product. Depending on the considered species, cobalt has multiple industrial applications including the production of alloys and hard metal, diamond polishing, drying agents, pigments and catalysts. Cobalt is an essential component of Vitamin B12 (hydroxycolalamin). Cobalt functions as a co-factor in enzyme catalysed reactions and is involved in the production of erythropoietin, a hormone that stimulates the formation of erythrocytes. Cobalt salts were used to treat anemia and stimulate erythropoiesis, but was withdrawn from market since Co(II) cations are genotoxic in vitro and in vivo, and carcinogenic in rodents. Hovewer, Co salts are reported to be used by athletes as a doping

Originator

Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q9NWT6
Gene ID: 55662.0
Gene Symbol: HIF1AN
Target Organism: Homo sapiens (Human)
1.0 µM [Ki]
Conditions
PubMed

PubMed

TitleDatePubMed
Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes.
1990 Dec 1
Cobalt and antimony: genotoxicity and carcinogenicity.
2003 Dec 10
Synthesis and antifungal potential of Co(II) complexes of 1-(2'-hydroxyphenyl) ethylideneanilines.
2006 Feb
In vitro assessment of cobalt oxide particle toxicity: identifying and circumventing interference.
2013 Sep
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Thu Jul 06 01:59:27 UTC 2023
Edited
by admin
on Thu Jul 06 01:59:27 UTC 2023
Record UNII
AI1MR454XG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
COBALTOUS CATION
Common Name English
CO2+
Common Name English
COBALT(II) CATION
Common Name English
COBALT CATION (CO2+)
Common Name English
COBALT(II) ION
Common Name English
COBALTOUS ION
Common Name English
COBALT, ION (CO2+)
Common Name English
COBALT(2+)
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C68247
Created by admin on Thu Jul 06 01:59:27 UTC 2023 , Edited by admin on Thu Jul 06 01:59:27 UTC 2023
Code System Code Type Description
EPA CompTox
DTXSID20177066
Created by admin on Thu Jul 06 01:59:27 UTC 2023 , Edited by admin on Thu Jul 06 01:59:27 UTC 2023
PRIMARY
DAILYMED
AI1MR454XG
Created by admin on Thu Jul 06 01:59:27 UTC 2023 , Edited by admin on Thu Jul 06 01:59:27 UTC 2023
PRIMARY
NCI_THESAURUS
C68248
Created by admin on Thu Jul 06 01:59:27 UTC 2023 , Edited by admin on Thu Jul 06 01:59:27 UTC 2023
PRIMARY
CAS
22541-53-3
Created by admin on Thu Jul 06 01:59:27 UTC 2023 , Edited by admin on Thu Jul 06 01:59:27 UTC 2023
PRIMARY
RXCUI
1546419
Created by admin on Thu Jul 06 01:59:27 UTC 2023 , Edited by admin on Thu Jul 06 01:59:27 UTC 2023
PRIMARY RxNorm
PUBCHEM
104729
Created by admin on Thu Jul 06 01:59:27 UTC 2023 , Edited by admin on Thu Jul 06 01:59:27 UTC 2023
PRIMARY
DRUG BANK
DB14205
Created by admin on Thu Jul 06 01:59:27 UTC 2023 , Edited by admin on Thu Jul 06 01:59:27 UTC 2023
PRIMARY
FDA UNII
AI1MR454XG
Created by admin on Thu Jul 06 01:59:27 UTC 2023 , Edited by admin on Thu Jul 06 01:59:27 UTC 2023
PRIMARY
CHEBI
48828
Created by admin on Thu Jul 06 01:59:27 UTC 2023 , Edited by admin on Thu Jul 06 01:59:27 UTC 2023
PRIMARY
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