Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H12N2O8.Co.2Na |
| Molecular Weight | 393.1236 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[Co++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O
InChI
InChIKey=SRRLDCNCJFKVFJ-UHFFFAOYSA-J
InChI=1S/C10H16N2O8.Co.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4
| Molecular Formula | Na |
| Molecular Weight | 22.98976928 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C10H12N2O8 |
| Molecular Weight | 288.2109 |
| Charge | -4 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Co |
| Molecular Weight | 58.933195 |
| Charge | 2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionSources: http://www.edta-chelate.com/cobalt-edta-1640873.html | https://www.ncbi.nlm.nih.gov/pubmed/13641039http://bookshop.europa.eu/en/antidotes-for-poisoning-by-cyanide-pbEUNA14280/downloads/EU-NA-14280-EN-C/EUNA14280ENC_001.pdf;pgid=y8dIS7GUWMdSR0EAlMEUUsWb0000TB7pJDF9?FileName=EUNA14280ENC_001.pdf&SKU=EUNA14280ENC_PDF&CatalogueNumber=EU-NA-14280-EN-C'Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/6787340 | https://www.drugs.com/uk/dicobalt-edetate-injection-300mg-leaflet.html
Sources: http://www.edta-chelate.com/cobalt-edta-1640873.html | https://www.ncbi.nlm.nih.gov/pubmed/13641039http://bookshop.europa.eu/en/antidotes-for-poisoning-by-cyanide-pbEUNA14280/downloads/EU-NA-14280-EN-C/EUNA14280ENC_001.pdf;pgid=y8dIS7GUWMdSR0EAlMEUUsWb0000TB7pJDF9?FileName=EUNA14280ENC_001.pdf&SKU=EUNA14280ENC_PDF&CatalogueNumber=EU-NA-14280-EN-C'
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/6787340 | https://www.drugs.com/uk/dicobalt-edetate-injection-300mg-leaflet.html
Dicobalt edetate was developed as a cyanide antidote based on the known ability of cobalt to form stable complexes with cyanide. One current cobalt-based antidote available in Europe is dicobalt-EDTA, sold as Kelocyanor. This agent chelates cyanide as the cobalticyanide. This drug provides an antidote effect more quickly than formation of methemoglobin. It can be very toxic and cause seizures, upper airway oedema, chest pain, hypotension, vomiting, rashes and dyspnoea especially in those who have not be exposed to cyanide.
Originator
Sources: http://www.edta-chelate.com/cobalt-edta-1640873.htmlhttps://www.ncbi.nlm.nih.gov/pubmed/14256807
Curator's Comment: The first use of cobalt compounds as cyanide antagonists was advocated by Antal J. in 1894. http://www.firesmoke.org/wp-content/uploads/2010/10/Cyanide_As_A_Weapon.pdf
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P79226 Gene ID: 1.00328928E8 Gene Symbol: ALDOB Target Organism: Oryctolagus cuniculus (Rabbit) |
|||
Target ID: CHEMBL5798 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | SWITCH C Hi Mineral Approved UseRecommended use: Low dose oral drench for the treatment and control of internal
parasites in cattle |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Curative | KELOCYANOR Approved UseDicobalt Edetate Injection is a specific antidote for acute cyanide poisoning. In view of the difficulty of certain diagnosis in emergency situations, it is recommended that Dicobalt Edetate Injection only be given when the patient is tending to lose or has lost consciousness. |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
9.8 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25414476/ |
4.28 mg/kg single, intravenous dose: 4.28 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
COBALT plasma | Sus scrofa population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
518 μg × min/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25414476/ |
4.28 mg/kg single, intravenous dose: 4.28 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
COBALT plasma | Sus scrofa population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
136 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/25414476/ |
4.28 mg/kg single, intravenous dose: 4.28 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
COBALT plasma | Sus scrofa population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Separation of digesta fractions complicates estimation of ileal digestibility using marker methods with Cr2O3 and cobalt-ethylenediamine tetraacetic acid in broiler chickens. | 2014-08 |
|
| Evaluation of the double-disk synergy test for New Delhi metallo-β-lactamase-1 and other metallo-β-lactamase producing gram-negative bacteria by using metal-ethylenediaminetetraacetic acid complexes. | 2013-05 |
|
| Cobalt-induced changes in the spleen of mice from different stages of development. | 2012 |
|
| Ruminal infusions of cobalt-EDTA reduce mammary delta9-desaturase index and alter milk fatty acid composition in lactating cows. | 2008-04 |
|
| Activation of rabbit kidney fructose diphosphatase by Mg-EDTA, Mn-EDTA and Co-EDTA complexes. | 1973-01 |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Also was used orally in rats: Cobalt disodium ethylenediamine tetra-acetate in a
dosage of 4, 8, 10, 20, 40 mg/Kg of elemental cobalt had no
effect on the weight gain of weanling rats.
Rabbits: Rabbits receiving 50 mg/Kg of elemental cobalt
intravenously, given as cobalt disodium ethylenediamine
tetra-acetate (Cobalt Disodium Edetate), showed no detectable toxic
symptoms. Approximately 100 mg/Kg elemental cobalt, administered as rapidly
as possible, still produced no toxic symptoms except
for a questionable increase in respiratory rate.
Route of Administration:
Intravenous
| Substance Class |
Chemical
Created
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3EY1Y2QRLI
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1722037
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PARENT -> SALT/SOLVATE |
