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Details

Stereochemistry ACHIRAL
Molecular Formula Co.S
Molecular Weight 90.998
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COBALTOUS SULFIDE

SMILES

[S--].[Co++]

InChI

InChIKey=INPLXZPZQSLHBR-UHFFFAOYSA-N
InChI=1S/Co.S/q+2;-2

HIDE SMILES / InChI
Molecular Formula HS
Molecular Weight 33.073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Co
Molecular Weight 58.9332
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/104729ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pgISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://fscimage.fishersci.com/msds/05330.htmhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttp://datasheets.scbt.com/sc-227251.pdf
Curator's Comment: description was created based on several sources, including: DOI:10.1080/00958970802416020 | DOI:10.1080/00958972.2010.521553 | https://www.ncbi.nlm.nih.gov/pubmed/7201957 | https://www.ncbi.nlm.nih.gov/pubmed/18475879

Cobaltous iodide is a catalyst used in organic synthesis.

Originator

Brandt, G.
20
Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Hypoxia-inducible factor 1-alpha inhibitor
22
Target ID: Q9NWT6
Gene ID: 55662.0
Gene Symbol: HIF1AN
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 1.0 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes.
1990 Dec 1
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.
2005 Aug
Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice.
2016 Aug 15
Patents

Patents

US20150010463
20
US3459677 A
20
US4326084
20
US5718844
20
US6740618 B2
20
WO2014127808A1
20

Sample Use Guides

In Vivo Use Guide
For treatment of anemia, oral cobal chloride was administered at doses 25 mg and 50 mg daily.
Route of Administration: Oral
In Vitro Use Guide
HIF asparaginyl hydroxylase activity was measured by a method based on the hydroxylation coupled decarboxylation of 2-oxoglutarate with the synthetic HIF-1α peptides in the presence of varying concentrations of Co (1-5 uM). Ki for HIF asparaginyl hydroxylase was 1uM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:40:29 GMT 2023
Edited
by admin
on Fri Dec 15 19:40:29 GMT 2023
Record UNII
INZ5E36Y1V
Record Status Validated (UNII)
Record Version
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Name Type Language
COBALTOUS SULFIDE
MI  
Common Name English
COBALTOUS SULFIDE [MI]
Common Name English
COBALT SULPHIDE
Systematic Name English
COBALT MONOSULFIDE [HSDB]
Common Name English
COBALT(II) SULFIDE
Systematic Name English
COBALT SULFIDE
Systematic Name English
COBALT MONOSULFIDE
HSDB  
Systematic Name English
Code System Code Type Description
MERCK INDEX
m3703
Created by admin on Fri Dec 15 19:40:29 GMT 2023 , Edited by admin on Fri Dec 15 19:40:29 GMT 2023
PRIMARY Merck Index
FDA UNII
INZ5E36Y1V
Created by admin on Fri Dec 15 19:40:29 GMT 2023 , Edited by admin on Fri Dec 15 19:40:29 GMT 2023
PRIMARY
WIKIPEDIA
COBALT SULFIDE
Created by admin on Fri Dec 15 19:40:29 GMT 2023 , Edited by admin on Fri Dec 15 19:40:29 GMT 2023
PRIMARY
CAS
1317-42-6
Created by admin on Fri Dec 15 19:40:29 GMT 2023 , Edited by admin on Fri Dec 15 19:40:29 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-273-3
Created by admin on Fri Dec 15 19:40:29 GMT 2023 , Edited by admin on Fri Dec 15 19:40:29 GMT 2023
PRIMARY
PUBCHEM
159453
Created by admin on Fri Dec 15 19:40:29 GMT 2023 , Edited by admin on Fri Dec 15 19:40:29 GMT 2023
PRIMARY
MESH
C027875
Created by admin on Fri Dec 15 19:40:29 GMT 2023 , Edited by admin on Fri Dec 15 19:40:29 GMT 2023
PRIMARY
HSDB
5448
Created by admin on Fri Dec 15 19:40:29 GMT 2023 , Edited by admin on Fri Dec 15 19:40:29 GMT 2023
PRIMARY
EPA CompTox
DTXSID80892187
Created by admin on Fri Dec 15 19:40:29 GMT 2023 , Edited by admin on Fri Dec 15 19:40:29 GMT 2023
PRIMARY
Related Record Type Details
Structure of HYDROGEN SULFIDE
PARENT -> SALT/SOLVATE
Structure of COBALTOUS CATION
PARENT -> SALT/SOLVATE
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