Details
Stereochemistry | ACHIRAL |
Molecular Formula | Co.S |
Molecular Weight | 90.998 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[S--].[Co++]
InChI
InChIKey=INPLXZPZQSLHBR-UHFFFAOYSA-N
InChI=1S/Co.S/q+2;-2
Molecular Formula | HS |
Molecular Weight | 33.073 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Co |
Molecular Weight | 58.933195 |
Charge | 2 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pghttps://fscimage.fishersci.com/msds/05330.htmhttp://datasheets.scbt.com/sc-227251.pdfISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttps://pubchem.ncbi.nlm.nih.gov/compound/104729Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14643417 | https://www.ncbi.nlm.nih.gov/pubmed/16244201
Sources: ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pghttps://fscimage.fishersci.com/msds/05330.htmhttp://datasheets.scbt.com/sc-227251.pdfISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttps://pubchem.ncbi.nlm.nih.gov/compound/104729
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14643417 | https://www.ncbi.nlm.nih.gov/pubmed/16244201
Cobalt is a transition metal, naturally ocurring in the minerals cobaltite, smaltite, and erythrite, and is often associated with nickel, silver, lead, copper, and iron ores, from which it is most frequently obtained as a by-product. Depending on the considered species, cobalt has multiple industrial applications including the production of alloys and hard metal, diamond polishing, drying agents, pigments and catalysts. Cobalt is an essential component of Vitamin B12 (hydroxycolalamin). Cobalt functions as a co-factor in enzyme catalysed reactions and is involved in the production of erythropoietin, a hormone that stimulates the formation of erythrocytes. Cobalt salts were used to treat anemia and stimulate erythropoiesis, but was withdrawn from market since Co(II) cations are genotoxic in vitro and in vivo, and carcinogenic in rodents. Hovewer, Co salts are reported to be used by athletes as a doping
Originator
Sources: http://www.rsc.org/periodic-table/element/27/cobalt
Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Q9NWT6 Gene ID: 55662.0 Gene Symbol: HIF1AN Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15941769 |
1.0 µM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Acute oral toxicity of inorganic cobalt compounds in rats. | 1982 Jun |
|
Synthesis and Anti-Candida Activity of Cobalt(II) Complexes of Benzene-1,2-Dioxyacetic Acid (bdoaH(2)). X-Ray Crystal Structures of [Co(bdoa)(H(2)O)(3)] 3.5H(2)O and {[CO(phen)(3)](bdoa)}(2)24H(2)O (phen = 1,10-Phenanthroline). | 1999 |
|
Determination of trace metal ions in common salt by stripping voltammetry. | 1999 Nov-Dec |
|
Cobalt and antimony: genotoxicity and carcinogenicity. | 2003 Dec 10 |
|
Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals. | 2009 Apr |
|
Purification and characterization of glucose 6-phosphate dehydrogenase enzyme from rainbow trout (Oncorhynchus mykiss) liver and investigation of the effects of some metal ions on enzyme activity. | 2015 May |
Substance Class |
Chemical
Created
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Record UNII |
INZ5E36Y1V
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Record Status |
Validated (UNII)
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m3703
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COBALT SULFIDE
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE | |||
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PARENT -> SALT/SOLVATE |