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Details

Stereochemistry ACHIRAL
Molecular Formula CO3.2Fe.4Mg.12HO
Molecular Weight 473.007
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERMAGATE ANHYDROUS

SMILES

[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg++].[Mg++].[Mg++].[Mg++].[Fe+3].[Fe+3].[O-]C([O-])=O

InChI

InChIKey=HBHWBHDZABTVTA-UHFFFAOYSA-A
InChI=1S/CH2O3.2Fe.4Mg.12H2O/c2-1(3)4;;;;;;;;;;;;;;;;;;/h(H2,2,3,4);;;;;;;12*1H2/q;2*+3;4*+2;;;;;;;;;;;;/p-14

HIDE SMILES / InChI

Molecular Formula Mg
Molecular Weight 24.305
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula CO3
Molecular Weight 60.0089
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

FERMAGATE is a phosphate binder with phosphate plasma levels lowering activity. It is in Phase 3 development in the US and in Europe for the treatment of hyperphosphatemia in dialysis patients. It is made up of magnesium and ferric iron atoms held in an insoluble, rigid, crystalline-layered structure, with carbonate groups lying between the layers. Upon oral administration, the carbonate ions in FERMAGATE are exchanged for free phosphate ions released from food in the gastrointestinal tract; thereby, strongly binding phosphate. This inhibits phosphate uptake and preventing hyperphosphatemia.

Approval Year

PubMed

PubMed

TitleDatePubMed
Iron-magnesium hydroxycarbonate (fermagate): a novel non-calcium-containing phosphate binder for the treatment of hyperphosphatemia in chronic hemodialysis patients.
2009 Feb

Sample Use Guides

Recommended daily dose: 3000 mg, three pills per day.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 17 13:01:44 UTC 2022
Edited
by admin
on Sat Dec 17 13:01:44 UTC 2022
Record UNII
4VNO5L64GQ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERMAGATE ANHYDROUS
Common Name English
IRON MAGNESIUM CARBONATE HYDROXIDE (FE2MG4(CO3)(OH)12)
Common Name English
DIIRON(III) TETRAMAGNESIUM CARBONATE DODECAHYDROXIDE
Common Name English
FERRATE (FE(OH)63-), (OC-6-11)-, MAGNESIUM CARBONATE (2:4:1)
Common Name English
Code System Code Type Description
FDA UNII
4VNO5L64GQ
Created by admin on Sat Dec 17 13:01:44 UTC 2022 , Edited by admin on Sat Dec 17 13:01:44 UTC 2022
PRIMARY
CAS
96492-32-9
Created by admin on Sat Dec 17 13:01:44 UTC 2022 , Edited by admin on Sat Dec 17 13:01:44 UTC 2022
PRIMARY
PUBCHEM
56649436
Created by admin on Sat Dec 17 13:01:44 UTC 2022 , Edited by admin on Sat Dec 17 13:01:44 UTC 2022
PRIMARY
EPA CompTox
DTXSID10242277
Created by admin on Sat Dec 17 13:01:44 UTC 2022 , Edited by admin on Sat Dec 17 13:01:44 UTC 2022
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS