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Details

Stereochemistry ACHIRAL
Molecular Formula CO3.2Fe.4Mg.12HO.4H2O
Molecular Weight 545.068
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERMAGATE

SMILES

O.O.O.O.[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg++].[Mg++].[Mg++].[Mg++].[Fe+3].[Fe+3].[O-]C([O-])=O

InChI

InChIKey=VESOWWBEYMMDFG-UHFFFAOYSA-A
InChI=1S/CH2O3.2Fe.4Mg.16H2O/c2-1(3)4;;;;;;;;;;;;;;;;;;;;;;/h(H2,2,3,4);;;;;;;16*1H2/q;2*+3;4*+2;;;;;;;;;;;;;;;;/p-14

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula CH2O3
Molecular Weight 62.0248
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Mg
Molecular Weight 24.305
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

FERMAGATE is a phosphate binder with phosphate plasma levels lowering activity. It is in Phase 3 development in the US and in Europe for the treatment of hyperphosphatemia in dialysis patients. It is made up of magnesium and ferric iron atoms held in an insoluble, rigid, crystalline-layered structure, with carbonate groups lying between the layers. Upon oral administration, the carbonate ions in FERMAGATE are exchanged for free phosphate ions released from food in the gastrointestinal tract; thereby, strongly binding phosphate. This inhibits phosphate uptake and preventing hyperphosphatemia.

Approval Year

PubMed

PubMed

TitleDatePubMed

Sample Use Guides

Recommended daily dose: 3000 mg, three pills per day.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:09:11 GMT 2023
Edited
by admin
on Fri Dec 15 16:09:11 GMT 2023
Record UNII
LH78JQC1MP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERMAGATE
INN  
INN  
Official Name English
DIIRON(III) TETRAMAGNESIUM CARBONATE DODECAHYDROXIDE-WATER (1/4)
Common Name English
IRON MAGNESIUM CARBONATE HYDROXIDE(FE2MG4(CO3)(OH)12) TETRAHYDRATE
Common Name English
ALPHAREN
Brand Name English
fermagate [INN]
Common Name English
FERRATE (FE(OH)63-), (OC-6-11)-, MAGNESIUM CARBONATE (2:4:1), TETRAHYDRATE
Common Name English
FERRATE (FE(OH)63-), (OC-6-11)-, MAGNESIUM CARBONATE, HYDRATE (2:4:1:4)
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C78275
Created by admin on Fri Dec 15 16:09:11 GMT 2023 , Edited by admin on Fri Dec 15 16:09:11 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C81345
Created by admin on Fri Dec 15 16:09:11 GMT 2023 , Edited by admin on Fri Dec 15 16:09:11 GMT 2023
PRIMARY
EVMPD
SUB126750
Created by admin on Fri Dec 15 16:09:11 GMT 2023 , Edited by admin on Fri Dec 15 16:09:11 GMT 2023
PRIMARY
SMS_ID
100000152995
Created by admin on Fri Dec 15 16:09:11 GMT 2023 , Edited by admin on Fri Dec 15 16:09:11 GMT 2023
PRIMARY
MESH
C541219
Created by admin on Fri Dec 15 16:09:11 GMT 2023 , Edited by admin on Fri Dec 15 16:09:11 GMT 2023
PRIMARY
EPA CompTox
DTXSID70152328
Created by admin on Fri Dec 15 16:09:11 GMT 2023 , Edited by admin on Fri Dec 15 16:09:11 GMT 2023
PRIMARY
INN
8948
Created by admin on Fri Dec 15 16:09:11 GMT 2023 , Edited by admin on Fri Dec 15 16:09:11 GMT 2023
PRIMARY
FDA UNII
LH78JQC1MP
Created by admin on Fri Dec 15 16:09:11 GMT 2023 , Edited by admin on Fri Dec 15 16:09:11 GMT 2023
PRIMARY
PUBCHEM
71491874
Created by admin on Fri Dec 15 16:09:11 GMT 2023 , Edited by admin on Fri Dec 15 16:09:11 GMT 2023
PRIMARY
CAS
119175-48-3
Created by admin on Fri Dec 15 16:09:11 GMT 2023 , Edited by admin on Fri Dec 15 16:09:11 GMT 2023
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE
PARENT -> SALT/SOLVATE