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Details

Stereochemistry ACHIRAL
Molecular Formula 3C6H5O3.Fe
Molecular Weight 431.151
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERRIC MALTOL

SMILES

[Fe+3].CC1=C([O-])C(=O)C=CO1.CC2=C([O-])C(=O)C=CO2.CC3=C([O-])C(=O)C=CO3

InChI

InChIKey=AHPWLYJHTFAWKI-UHFFFAOYSA-K
InChI=1S/3C6H6O3.Fe/c3*1-4-6(8)5(7)2-3-9-4;/h3*2-3,8H,1H3;/q;;;+3/p-3

HIDE SMILES / InChI
Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C6H5O3
Molecular Weight 125.1021
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: http://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=falsehttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.htmlhttps://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttps://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505
Curator's Comment: description was created based on several sources, including https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol3/pdf/CFR-1996-title21-vol3-sec182-5375.pdf

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Monsanto Chemicals
44
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Chelating Agent
142
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Approved
8429
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8429
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8429
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Curative
Approved
8429
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

2003
Palliative
Approved
8429
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
The formation of ferritin from apoferritin. Catalytic action of apoferritin.
1973 Oct
Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats.
1989
Non-invasive and non-destructive micro-XRF and micro-Raman analysis of a decorative wallpaper from the beginning of the 19th century.
2007 Feb
Metal-mediated cyclization of aryl and benzyl glycidyl ethers: a complete scenario.
2008 Dec 17
Oxidative aromatic C-N bond formation: convenient synthesis of N-amino-3-nitrile-indoles via FeBr3-mediated intramolecular cyclization.
2011 May 21
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.
2013 Apr
Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes.
2016 May 17
Superior electrochemical performance of N-doped nanocrystalline FeF(3)/C with a single-step solid-state process.
2016 Oct 4
Phosphorus recovery from biogas slurry by ultrasound/H(2)O(2) digestion coupled with HFO/biochar adsorption process.
2017 Feb
Effect of iron and carbon monoxide on fibrinogenase-like degradation of plasmatic coagulation by venoms of four Crotalus species.
2017 Jan
A Simplified Fe-Based PhotoATRP Using Only Monomers and Solvent.
2017 Jul
Patents

Patents

20080188032
44
20090216060
44
6258758
44
US 5206265 A
44
US2385188
44
US3873678
44
US4364871
44
US6881255
44
US6903235
44
US7198668
44
US8071067
44

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:51:20 GMT 2023
Edited
by admin
on Fri Dec 15 15:51:20 GMT 2023
Record UNII
MA10QYF1Z0
Record Status Validated (UNII)
Record Version
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Name Type Language
FERRIC MALTOL
INN   WHO-DD  
USAN   INN  
Official Name English
Ferric maltol [WHO-DD]
Common Name English
FERRIC MALTOL [MI]
Common Name English
FERRIC MALTOL [ORANGE BOOK]
Common Name English
IRON, TRIS(3-(HYDROXY-.KAPPA.O)-2-METHYL-4H-PYRAN-4-ONATO-.KAPPA.O4)-
Systematic Name English
FERRIC MALTOL [USAN]
Common Name English
Tris[3-(hydroxy-κO)-2-methyl-4H-pyran-4-onato-κO4]iron(III)
Common Name English
ST-10
Code English
ST10
Code English
IRON MALTOL
Common Name English
ST10-021
Code English
ferric maltol [INN]
Common Name English
Classification Tree Code System Code
WHO-ATC B03AB10
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
Code System Code Type Description
DRUG BANK
DB15598
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
PUBCHEM
169535
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
NCI_THESAURUS
C174702
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
DRUG CENTRAL
5076
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
DAILYMED
MA10QYF1Z0
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
INN
9974
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
CAS
33725-54-1
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
RXCUI
2539932
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
SMS_ID
100000159704
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
MERCK INDEX
m11933
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
WIKIPEDIA
Ferric maltol
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
USAN
GH-72
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
EVMPD
SUB170121
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
FDA UNII
MA10QYF1Z0
Created by admin on Fri Dec 15 15:51:21 GMT 2023 , Edited by admin on Fri Dec 15 15:51:21 GMT 2023
PRIMARY
Related Record Type Details
Structure of FERRIC CATION
PARENT -> SALT/SOLVATE
Structure of MALTOL
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of FERRIC CATION
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