FERRIC NITRILOTRIACETATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H6NO6.Fe
Molecular Weight	243.96
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Fe+3].[O-]C(=O)CN(CC([O-])=O)CC([O-])=O

InChI

InChIKey=FXDLIMJMHVKXAR-UHFFFAOYSA-K

InChI=1S/C6H9NO6.Fe/c8-4(9)1-7(2-5(10)11)3-6(12)13;/h1-3H2,(H,8,9)(H,10,11)(H,12,13);/q;+3/p-3

HIDE SMILES / InChI

Molecular Formula	Fe
Molecular Weight	55.845
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H6NO6
Molecular Weight	188.1149
Charge	-3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB.	2013-02-04	23194824
Oxidation and turnover of renal metallothioneins after an injection of ferric nitrilotriacetate.	2012-01-05	22001350
Aberrant activation of ubiquitin D at G2 phase and apoptosis by carcinogens that evoke cell proliferation after 28-day administration in rats.	2012	23208426
Preclinical renal cancer chemopreventive efficacy of geraniol by modulation of multiple molecular pathways.	2011-11-28	21907755
Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice.	2009-09-01	19482077
Oxidative changes in the rat brain by intraperitoneal injection of ferric nitrilotriacetate.	2009	19490752
Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity.	2008-09-15	18617210
Asbestos induces doxorubicin resistance in MM98 mesothelioma cells via HIF-1alpha.	2008-08	18385176
Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats.	2008-04	18684806
Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway.	2007-12	18055543
Iron stimulates urokinase plasminogen activator expression and activates NF-kappa B in human prostate cancer cells.	2007	17571974
CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation.	2006-12	17034788
Alpha-tocopherol induces calnexin in renal tubular cells: another protective mechanism against free radical-induced cellular damage.	2006-09-15	16908007
Oxidative stress induces phosphoenolpyruvate carboxykinase expression in H4IIE cells.	2006-09	16960379
Cytoglobin overexpression protects against damage-induced fibrosis.	2006-06	16581302
Susceptibility of actin to modification by 4-hydroxy-2-nonenal.	2005-11-15	15886073
Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis.	2005-06	15834431
Inhibitory effects of idoxifene on hepatic fibrosis in rats.	2005-05	15842777
Induction of hepatic and renal metallothionein synthesis by ferric nitrilotriacetate in mice: the role of MT as an antioxidant.	2005-04-01	15781289
Vitamin E inhibits hepatic oxidative stress, toxicity and hyperproliferation in rats treated with the renal carcinogen ferric nitrilotriacetate.	2005	15949125
Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress.	2003-12-19	14623030
Doxorubicin induces an increase of nitric oxide synthesis in rat cardiac cells that is inhibited by iron supplementation.	2002-12-01	12490132
Protective effect of metallothionein-III on DNA damage in response to reactive oxygen species.	2002-10-10	12383939
Antioxidant and pro-oxidant effects of a manganese porphyrin complex against CYP2E1-dependent toxicity.	2002-07-01	12086689
Iron treatment downregulates DMT1 and IREG1 mRNA expression in Caco-2 cells.	2002-04	11925462
Effect of nitric oxide on iron-mediated cytotoxicity in primary cultured renal proximal tubules.	2001-12	11746204
Iron inhibits the nitric oxide synthesis elicited by asbestos in murine macrophages.	2001-08-01	11461780
Inhibition of the NA(+)/H(+) exchanger reduces rat hepatic stellate cell activity and liver fibrosis: an in vitro and in vivo study.	2001-02	11159895
Molecular mechanisms by which iron induces nitric oxide synthesis in cultured proximal tubule cells.	2001	11340304
Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress.	2000-06	10854235
MAP kinase-independent induction of proto-oncogene c-fos mRNA by hemin in human cells.	1999-06-24	10381381
Ferric nitrilotriacetate promotes N-diethylnitrosamine-induced renal tumorigenesis in the rat: implications for the involvement of oxidative stress.	1998-06	9667754
Evaluation of apoptosis and cell proliferation in experimentally induced renal cysts.	1998	9879822
Vitamin E inhibits apoptosis, DNA modification, and cancer incidence induced by iron-mediated peroxidation in Wistar rat kidney.	1997-06-15	9192818
Overexpression of integrin-associated protein (CD47) in rat kidney treated with a renal carcinogen, ferric nitrilotriacetate.	1997-02	9119739
Expression of structure-specific recognition protein mRNA in fetal kidney and Fe-nitrilotriacetate-induced renal carcinoma in the rat.	1996-09-10	8844983
Transforming growth factor-alpha expression of renal proximal tubules in Wistar rats treated with ferric and aluminum nitrilotriacetate.	1993-06	8340253
Mechanism of iron potentiation of hepatic uroporphyria: studies in cultured chick embryo liver cells.	1989-09	2759551
Effect of dietary vitamin E on ferric nitrilotriacetate-induced nephrotoxicity in rats.	1988-03-15	3353995

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:56:43 GMT 2025` Edited by `admin` on `Mon Mar 31 19:56:43 GMT 2025`
Record UNII	Z3U5ED15B9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FERRIC NITRILOTRIACETATE

Common Name

English

FE(III)-NTA COMPLEX (1:1

Preferred Name

English

IRON, (N,N-BIS((CARBOXY-.KAPPA.O)METHYL)GLYCINATO(3-)-.KAPPA.N,.KAPPA.O)-, (T-4)-

Systematic Name

English

FERRIC NITRILOTRIACETATE [HSDB]

Common Name

English

IRON(III) NITRILOTRIACETATE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID60167764