FERRIC NITRILOTRIACETATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H6NO6.Fe
Molecular Weight	243.96
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Fe+3].[O-]C(=O)CN(CC([O-])=O)CC([O-])=O

InChI

InChIKey=FXDLIMJMHVKXAR-UHFFFAOYSA-K

InChI=1S/C6H9NO6.Fe/c8-4(9)1-7(2-5(10)11)3-6(12)13;/h1-3H2,(H,8,9)(H,10,11)(H,12,13);/q;+3/p-3

HIDE SMILES / InChI

Molecular Formula	C6H6NO6
Molecular Weight	188.1149
Charge	-3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Fe
Molecular Weight	55.845
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Transforming growth factor-alpha expression of renal proximal tubules in Wistar rats treated with ferric and aluminum nitrilotriacetate.	1993 Jun	8340253
Expression of structure-specific recognition protein mRNA in fetal kidney and Fe-nitrilotriacetate-induced renal carcinoma in the rat.	1996 Sep 10	8844983
Vitamin E inhibits apoptosis, DNA modification, and cancer incidence induced by iron-mediated peroxidation in Wistar rat kidney.	1997 Jun 15	9192818
Evaluation of apoptosis and cell proliferation in experimentally induced renal cysts.	1998	9879822
MAP kinase-independent induction of proto-oncogene c-fos mRNA by hemin in human cells.	1999 Jun 24	10381381
Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress.	2000 Jun	10854235
Molecular mechanisms by which iron induces nitric oxide synthesis in cultured proximal tubule cells.	2001	11340304
Iron inhibits the nitric oxide synthesis elicited by asbestos in murine macrophages.	2001 Aug 1	11461780
Inhibition of the NA(+)/H(+) exchanger reduces rat hepatic stellate cell activity and liver fibrosis: an in vitro and in vivo study.	2001 Feb	11159895
Antioxidant and pro-oxidant effects of a manganese porphyrin complex against CYP2E1-dependent toxicity.	2002 Jul 1	12086689
Vitamin E inhibits hepatic oxidative stress, toxicity and hyperproliferation in rats treated with the renal carcinogen ferric nitrilotriacetate.	2005	15949125
Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis.	2005 Jun	15834431
Susceptibility of actin to modification by 4-hydroxy-2-nonenal.	2005 Nov 15	15886073
Cytoglobin overexpression protects against damage-induced fibrosis.	2006 Jun	16581302
Alpha-tocopherol induces calnexin in renal tubular cells: another protective mechanism against free radical-induced cellular damage.	2006 Sep 15	16908007
Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway.	2007 Dec	18055543
Asbestos induces doxorubicin resistance in MM98 mesothelioma cells via HIF-1alpha.	2008 Aug	18385176
Preclinical renal cancer chemopreventive efficacy of geraniol by modulation of multiple molecular pathways.	2011 Nov 28	21907755
Aberrant activation of ubiquitin D at G2 phase and apoptosis by carcinogens that evoke cell proliferation after 28-day administration in rats.	2012	23208426
Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB.	2013 Feb 4	23194824

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:46:50 UTC 2023` Edited by `admin` on `Fri Dec 15 19:46:50 UTC 2023`
Record UNII	Z3U5ED15B9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FERRIC NITRILOTRIACETATE

Common Name

English

IRON, (N,N-BIS((CARBOXY-.KAPPA.O)METHYL)GLYCINATO(3-)-.KAPPA.N,.KAPPA.O)-, (T-4)-

Systematic Name

English

FERRIC NITRILOTRIACETATE [HSDB]

Common Name

English

FE(III)-NTA COMPLEX (1:1

Common Name

English

IRON(III) NITRILOTRIACETATE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID60167764