FERRIC SODIUM PYROPHOSPHATE

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Fe.Na.O7P2
Molecular Weight	252.778
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of FERRIC SODIUM PYROPHOSPHATE

Structure Search

SMILES

[Na+].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O

InChI

InChIKey=XWQGIDJIEPIQBD-UHFFFAOYSA-J

InChI=1S/Fe.Na.H4O7P2/c;;1-8(2,3)7-9(4,5)6/h;;(H2,1,2,3)(H2,4,5,6)/q+3;+1;/p-4

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Fe
Molecular Weight	55.845
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	O7P2
Molecular Weight	173.9433
Charge	-4
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.htmlhttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505https://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttp://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=false
Curator's Comment: description was created based on several sources, including https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol3/pdf/CFR-1996-title21-vol3-sec182-5375.pdf

Ferric sodium pyrophosphate is a salt, produced by combining sodium pyrophosphate with ferric citrate. It is used as a dietary supplement. The substance is generally recognized as safe when used in accordance with good manufacturing practice.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
transformed cell apoptotic process 106 Target ID: GO:0006927 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21121365	Activator 1410
Phosphate 43 Target ID: CHEMBL2364184 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdf	Chelating Agent 143

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2565
Unknown 2565
Parenteral Nutrition 49 Sources: https://www.hpra.ie/img/uploaded/swedocuments/2124555.PA0566_015_002.9e9eecde-fb07-4612-8f14-39d5233b7ace.000001Product%20Leaflet%20Approved.150327.pdf https://www.ncbi.nlm.nih.gov/pubmed/20377770	Primary	Approved 8360	Additrace N Approved Use A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Iron deficiency 80 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17511797	Preventing	Approved 8360	Parmirin Approved Use Preventive treatment of iron deficiency
Dental diseases 44 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13224146 https://www.ncbi.nlm.nih.gov/pubmed/286710	Primary	Basic research	Unknown Approved Use Unknown
Iron deficiency anemia 55 Sources: http://www.mfc.co.jp/english/eng/product/sanferol/page/3_11.html	Primary	Approved 8360	SANFEROL Approved Use It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Unknown 2565
Pain 608 Sources: https://www.drugs.com/inactive/ferric-oxide-yellow-381.html https://www.drugs.com/imprints/op-40-16159.html	Inactive ingredient	Approved 8360	Oxycontin Approved Use OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics. Launch Date 9.0935997E11
Unknown 2565
Chronic kidney disease 55 Sources: https://www.drugs.com/pro/ferric-citrate-tablets.html	Palliative	Approved 8360	AURYXIA Approved Use Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis. Launch Date 1.40978881E12

PubMed

Title	Date	PubMed
[Effects of ferric fluoride compounds on dental enamel].	1954 Nov 15	13224146
The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake.	1972 Jan	5075227
The formation of ferritin from apoferritin. Catalytic action of apoferritin.	1973 Oct	4797166
The absorption of iron as supplements in infant cereal and infant formulas.	1975 May	165454
Biological availability of iron supplements for rats, chicks and humans.	1976 Feb	1249649
Contact dermatitis to yellow iron oxide.	1985 Aug	4064645
Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats.	1989	2744824
Effect of physical exercise and vitamin C on absorption of ferric sodium citrate.	1996 Dec	8970140
New phosphate binding agents: ferric compounds.	1999 Jun	10361865
Non-invasive and non-destructive micro-XRF and micro-Raman analysis of a decorative wallpaper from the beginning of the 19th century.	2007 Feb	16838156
Interaction of omapatrilat with FD&C Blue No. 2 lake during dissolution of modified release tablets.	2007 Jul 18	17398043
Metal-mediated cyclization of aryl and benzyl glycidyl ethers: a complete scenario.	2008 Dec 17	19053452
Fabrication of FeF3 Nanoflowers on CNT branches and their application to high power lithium rechargeable batteries.	2010 Dec 7	20954196
Thermal behavior study and decomposition kinetics of amiodarone hydrochloride under isothermal conditions.	2011 Jun	21449701
Oxidative aromatic C-N bond formation: convenient synthesis of N-amino-3-nitrile-indoles via FeBr3-mediated intramolecular cyclization.	2011 May 21	21451828
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.	2013 Apr	23376265
Microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions and antimicrobial activities of the products.	2014 Aug 26	25255747
FeF(3) catalyzed cascade C-C and C-N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition.	2014 May	24504377
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.	2015 Nov 3	26478504
Nazarov cyclization of 1,4-pentadien-3-ols: preparation of cyclopenta[b]indoles and spiro[indene-1,4'-quinoline]s.	2016 Feb 14	26771024
Mechanisms and origins of the switchable regioselectivity of FeBr3-catalyzed [1,2]-aryl and [1,2]-alkyl shifts of α-aryl aldehydes.	2016 Feb 28	26822257
Halide Influence on Molecular and Supramolecular Arrangements of Iron Complexes with a 3,5-Bis(2-Pyridyl)-1,2,4,6-Thiatriazine Ligand.	2016 Jun 6	27152549
Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes.	2016 May 17	27072872
Superior electrochemical performance of N-doped nanocrystalline FeF(3)/C with a single-step solid-state process.	2016 Oct 4	27711351
Ferric Chloride-induced Murine Thrombosis Models.	2016 Sep 5	27684194
Phosphorus recovery from biogas slurry by ultrasound/H(2)O(2) digestion coupled with HFO/biochar adsorption process.	2017 Feb	27594573
Effect of iron and carbon monoxide on fibrinogenase-like degradation of plasmatic coagulation by venoms of four Crotalus species.	2017 Jan	26845427
A Simplified Fe-Based PhotoATRP Using Only Monomers and Solvent.	2017 Jul	27995746

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Bovine enamel was treated with 10 mM FeF3 (Ferric fluoride)

Substance Class	Chemical Created by `admin` on `Wed Jul 05 23:23:51 UTC 2023` Edited by `admin` on `Wed Jul 05 23:23:51 UTC 2023`
Record UNII	NGH4LHX6XQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FERRIC SODIUM PYROPHOSPHATE

Common Name

English

IRON SODIUM PYROPHOSPHATE (FENAP2O7)

Common Name

English

SODIUM IRON (III) PYROPHOSPHATE

Systematic Name

English

FERRIC SODIUM PYROPHOSPHATE [MI]

Common Name

English

Ferric sodium pyrophosphate [WHO-DD]

Common Name

English

IRON SODIUM PYROPHOSPHATE [HSDB]

Common Name

English

DIPHOSPHORIC ACID, IRON(3+) SODIUM SALT (1:1:1)

Common Name

English

SODIUM FERRIC PYROPHOSPHATE

Common Name

English

IRON(III) SODIUM PYROPHOSPHATE

Systematic Name

English

PYROPHOSPHORIC ACID, IRON(3+) SODIUM SALT (1:1:1)

Common Name

English

IRON SODIUM DIPHOSPHATE

Systematic Name

English

Code System Code Type Description

FDA UNII

NGH4LHX6XQ