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Details

Stereochemistry ACHIRAL
Molecular Formula H4O7P2
Molecular Weight 177.9751
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PYROPHOSPHORIC ACID

SMILES

OP(O)(=O)OP(O)(O)=O

InChI

InChIKey=XPPKVPWEQAFLFU-UHFFFAOYSA-N
InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)

HIDE SMILES / InChI

Molecular Formula H4O7P2
Molecular Weight 177.9751
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11401820 | https://www.ncbi.nlm.nih.gov/pubmed/27061894 | http://www.food-info.net/uk/e/e450.htm

Inorganic pyrophosphate (PPi ) has long been known as a by-product of many intracellular biosynthetic reactions. PPi plays the regulatory role in living systems, such as activities of enzymes, fidelity of syntheses of macromolecules, and proliferation of cells. PPi is used as a biochemical energy source instead of ATP especially in bacteria, protists, and plants. PPi may also regulate the formation and dissolution of bone as well as pathologic calcification of soft tissues and the formation of urinary stones. The formation of calcium pyrophosphate dihydrate crystals in the extracellular fluids of joints cause the disease called pseudogout. Sodium, potassium and calcium pyrophosphates (E450) are used as food additives as buffers and emulsifiers.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Stannous Pyrophosphate

Approved Use

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=30046b6b-09ea-46b1-8e60-61c53e1e7282
Diagnostic
Stannous Pyrophosphate

Approved Use

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=30046b6b-09ea-46b1-8e60-61c53e1e7282
Diagnostic
Stannous Pyrophosphate

Approved Use

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=30046b6b-09ea-46b1-8e60-61c53e1e7282
PubMed

PubMed

TitleDatePubMed
PPi analogs as inhibitors of human T-lymphotropic virus type III reverse transcriptase.
1986 May
Nucleoside triphosphates promote the transformation of Ah receptor to its DNA-binding form.
1991 Mar 1
Biochemical characterization of HIV-1 reverse transcriptases encoding mutations at amino acid residues 161 and 208 involved in resistance to phosphonoformate.
1998 Dec 15
Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz.
2005 Jan
Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors.
2008 Jun
Patents

Sample Use Guides

In Vivo Use Guide
Acceptable Daily Intake: Up to 70 mg/kg bodyweight for all pyrophosphate containing food additives
Route of Administration: Oral
In Vitro Use Guide
pyrophosphoric acid at the concentration of 0.1 - 1.0 mM does not affect spore germination of Streptomyces galilaeus ATCC 31133.
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:18:55 GMT 2023
Edited
by admin
on Fri Dec 15 17:18:55 GMT 2023
Record UNII
4E862E7GRQ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PYROPHOSPHORIC ACID
MI   WHO-DD  
Systematic Name English
Pyrophosphoric acid [WHO-DD]
Common Name English
PYROPHOSPHORIC ACID [MI]
Common Name English
DIPHSOPHORIC ACID
Common Name English
DIPHOSPHORIC-ACID
Systematic Name English
Classification Tree Code System Code
Food Contact Sustance Notif, (FCN No.) FCN NO. 962
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
Code System Code Type Description
CHEBI
29888
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY
DAILYMED
4E862E7GRQ
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY
RXCUI
1546425
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY RxNorm
EVMPD
SUB15065MIG
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY
DRUG BANK
DB04160
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY
MESH
C107241
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY
CAS
2466-09-3
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY
SMS_ID
100000078915
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY
FDA UNII
4E862E7GRQ
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY
MERCK INDEX
m9390
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
PYROPHOSPHORIC ACID
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY
PUBCHEM
1023
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY
EPA CompTox
DTXSID4075035
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY
ECHA (EC/EINECS)
219-574-0
Created by admin on Fri Dec 15 17:18:55 GMT 2023 , Edited by admin on Fri Dec 15 17:18:55 GMT 2023
PRIMARY
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