U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2Fe.3O4S.5H2O
Molecular Weight 489.954
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERRIC SULFATE

SMILES

O.O.O.O.O.[Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O

InChI

InChIKey=YHGPYBQVSJBGHH-UHFFFAOYSA-H
InChI=1S/2Fe.3H2O4S.5H2O/c;;3*1-5(2,3)4;;;;;/h;;3*(H2,1,2,3,4);5*1H2/q2*+3;;;;;;;;/p-6

HIDE SMILES / InChI

Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O4S
Molecular Weight 98.078
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Unknown

Approved Use

Unknown
Primary
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

9.0935997E11
Curative
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

1.06496642E12
Palliative
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

1.40978881E12
PubMed

PubMed

TitleDatePubMed
The absorption of iron as supplements in infant cereal and infant formulas.
1975 May
Contact dermatitis to yellow iron oxide.
1985 Aug
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.
2013 Apr
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
2015 Nov 3
Mechanisms and origins of the switchable regioselectivity of FeBr3-catalyzed [1,2]-aryl and [1,2]-alkyl shifts of α-aryl aldehydes.
2016 Feb 28
Superior electrochemical performance of N-doped nanocrystalline FeF(3)/C with a single-step solid-state process.
2016 Oct 4
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:50:31 UTC 2023
Edited
by admin
on Fri Dec 15 15:50:31 UTC 2023
Record UNII
3HWS7HF5XD
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERRIC SULFATE
USP   VANDF  
INCI  
Official Name English
FERRIC SULFATE [USP MONOGRAPH]
Common Name English
FERRIC TRISULFATE PENTAHYDRATE
Common Name English
AMERSEP-5320
Brand Name English
FERRIC SULPHATE HYDRATE
Common Name English
IRON SULFATE (FE2(SO4)3) HYDRATE
Common Name English
IRON(III) SULFATE HYDRATE
Systematic Name English
VISCOSTAT
Brand Name English
SULFURIC ACID, IRON(3+) SALT (3:2), HYDRATE
Common Name English
IRON(III) SULFATE PENTAHYDRATE
Systematic Name English
PIX 115
Brand Name English
FERRIC SULFATE HYDRATE
Common Name English
SULFURIC ACID, IRON(3+) SALT (3:2), PENTAHYDRATE
Common Name English
FERRIC SULFATE [VANDF]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 184.1307
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
EPA PESTICIDE CODE 34902
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
CONCEPT Industrial Aid
CAS
142906-29-4
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY
RXCUI
24913
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY RxNorm
NCI_THESAURUS
C76712
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY
CHEBI
53438
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY
DRUG CENTRAL
4529
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY
DAILYMED
3HWS7HF5XD
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY
CAS
15244-10-7
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
NON-SPECIFIC STOICHIOMETRY
FDA UNII
3HWS7HF5XD
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY
EVMPD
SUB21766
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY
MESH
C024823
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY
PUBCHEM
23443659
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY
DRUG BANK
DB11171
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY
WIKIPEDIA
Ferric sulfate
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY
EPA CompTox
DTXSID70934500
Created by admin on Fri Dec 15 15:50:31 UTC 2023 , Edited by admin on Fri Dec 15 15:50:31 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
ANHYDROUS->SOLVATE
Related Record Type Details
ACTIVE MOIETY