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Details

Stereochemistry ACHIRAL
Molecular Formula C6H5O7.Fe.3H2O
Molecular Weight 298.991
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERRIC CITRATE TRIHYDRATE

SMILES

O.O.O.[Fe+3].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

InChIKey=XIZOGMFSXFMCDT-UHFFFAOYSA-K
InChI=1S/C6H8O7.Fe.3H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;3*1H2/q;+3;;;/p-3

HIDE SMILES / InChI
Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C6H8O7
Molecular Weight 192.1235
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including http://www.mfc.co.jp/english/eng/product/sanferol/index.html

Ferric Ammonium EDTA Solution is normally used as a photographic chemical for a bleaching agent in the process of colour washing. It is also used as a complexing, and oxidizing agent & as a fertilizer and catalyst. EDTA acid are colourless, water-soluble solid that are widely used to dissolve scale. The usefulness of these ammonium salts arise because of its role as a chelating agent, i.e. its ability to "sequester" metal ions such as Ca2+ and Fe3+.

Originator

Monsanto Chemicals
40
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1468
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1447
Chelating Agent
139
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8583
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8583
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Palliative
Approved
8583
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
[Effects of ferric fluoride compounds on dental enamel].
1954 Nov 15
Thermal behavior study and decomposition kinetics of amiodarone hydrochloride under isothermal conditions.
2011 Jun
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.
2013 Apr
FeF(3) catalyzed cascade C-C and C-N bond formation: synthesis of differentially substituted triheterocyclic benzothiazole functionalities under solvent-free condition.
2014 May
Patents

Patents

20090216060
40
6258758
40
US 5206265 A
40
US2385188
40
US4364871
40
US6881255
40
US6903235
40
US7198668
40

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Bovine enamel was treated with 10 mM FeF3 (Ferric fluoride)
Substance Class Chemical
Created
by admin
on Mon Mar 31 20:20:01 GMT 2025
Edited
by admin
on Mon Mar 31 20:20:01 GMT 2025
Record UNII
756B6D74H4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERRIC CITRATE TRIHYDRATE
Common Name English
1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, IRON(3+) SALT, HYDRATE (1:1:3)
Preferred Name English
FERRIC CITRATE HYDRATE [JAN]
Common Name English
IRON(III) CITRATE TRIBASIC TRIHYDRATE
Common Name English
FERRIC CITRATE HYDRATE
Common Name English
Code System Code Type Description
SMS_ID
300000044039
Created by admin on Mon Mar 31 20:20:01 GMT 2025 , Edited by admin on Mon Mar 31 20:20:01 GMT 2025
PRIMARY
MESH
C025314
Created by admin on Mon Mar 31 20:20:01 GMT 2025 , Edited by admin on Mon Mar 31 20:20:01 GMT 2025
PRIMARY
FDA UNII
756B6D74H4
Created by admin on Mon Mar 31 20:20:01 GMT 2025 , Edited by admin on Mon Mar 31 20:20:01 GMT 2025
PRIMARY
CAS
17217-76-4
Created by admin on Mon Mar 31 20:20:01 GMT 2025 , Edited by admin on Mon Mar 31 20:20:01 GMT 2025
PRIMARY
PUBCHEM
56928187
Created by admin on Mon Mar 31 20:20:01 GMT 2025 , Edited by admin on Mon Mar 31 20:20:01 GMT 2025
PRIMARY
EPA CompTox
DTXSID0051788
Created by admin on Mon Mar 31 20:20:01 GMT 2025 , Edited by admin on Mon Mar 31 20:20:01 GMT 2025
PRIMARY
Related Record Type Details
Structure of FERRIC CITRATE ANHYDROUS
ANHYDROUS->SOLVATE
Structure of Anhydrous citric acid
PARENT -> SALT/SOLVATE
Structure of FERRIC CATION
PARENT -> SALT/SOLVATE
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