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Details

Stereochemistry ACHIRAL
Molecular Formula Fe.3HO
Molecular Weight 106.867
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERRIC HYDROXIDE

SMILES

[OH-].[OH-].[OH-].[Fe+3]

InChI

InChIKey=MSNWSDPPULHLDL-UHFFFAOYSA-K
InChI=1S/Fe.3H2O/h;3*1H2/q+3;;;/p-3

HIDE SMILES / InChI
Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: http://www.mfc.co.jp/english/eng/product/sanferol/pdf/fls_gras_notice.pdfhttps://mistralhowto.wordpress.com/2012/03/12/what-is-pigment-yellow-42-and-what-is-it-used-for/ | http://sensientfoodcolors.com/en-us/confection/iron-oxides-approved-by-the-fda/ | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=73.2250 | https://www.drugs.com/inactive/ferric-oxide-yellow-381.htmlhttps://books.google.ru/books?id=vxtxWneRBN4C&pg=PA1103&#v=onepage&q&f=falsehttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205874Orig1s000PharmR.pdfhttp://www.edta-chelate.com/ferric-ammonium-edta-liquid--1640836.htmlhttps://books.google.ru/books?id=3hLmyma2-MsC&pg=PA241&lpg=PA241&dq=FERRIC+AMMONIUM+CHLORIDE retrieved from A Consumer's Dictionary of Cosmetic Ingredients, 7th Edition: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics and Cosmeceuticals By Ruth Winterhttps://www.ncbi.nlm.nih.gov/pubmed/27995746 | http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01568/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=https://cameochemicals.noaa.gov/chemical/3468 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/27684194 | https://www.ncbi.nlm.nih.gov/pubmed/17511797 | https://www.ncbi.nlm.nih.gov/pubmed/1427505
Curator's Comment: description was created based on several sources, including https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol3/pdf/CFR-1996-title21-vol3-sec182-5375.pdf

Ferric chloride is a compound used as a food additive, a haemostatic or treatment for hypochromic anaemia. Ferric chloride induced vascular injury is a widely used model of occlusive thrombosis that reports platelet activation and aggregation in the context of an aseptic closed vascular system. Iron i.v. ferric chloride (960 mg) has being shown to be effective in correcting anaemia in HD patients with iron deficiency.

Originator

Monsanto Chemicals
44
Curator's Comment: The relation between phosphate level and ferric citrate consumption was first discovered in 1940s.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Chelating Agent
142
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Additrace N

Approved Use

A source of electrolytes and trace elements as an integral part of a complete intravenous nutritional regimen, for adults and children over 40 kg.
Preventing
Approved
8429
Parmirin

Approved Use

Preventive treatment of iron deficiency
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8429
SANFEROL

Approved Use

It has also been reported that SFC preparation improved iron deficiency in a pregnant woman with iron deficiency anemia whose hemoglobin level had not increased after administration of other iron preparations such as ferrous fumarate. A dairy supplemental dose of SFC improved iron deficiency in young women with iron deficiency.
Inactive ingredient
Approved
8429
Oxycontin

Approved Use

OxyContin is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

9.0935997E11
Curative
Approved
8429
RADIOGARDASE

Approved Use

Insoluble Prussian blue is indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.

Launch Date

1.06496642E12
Palliative
Approved
8429
AURYXIA

Approved Use

Ferric Citrate is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

Launch Date

1.40978881E12
PubMed

PubMed

TitleDatePubMed
The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake.
1972 Jan
Effect of physical exercise and vitamin C on absorption of ferric sodium citrate.
1996 Dec
New phosphate binding agents: ferric compounds.
1999 Jun
Finnish wallpaper pigments in the 18th-19th century: presence of KFe3(CrO4)2(OH)6 and odd pigment mixtures.
2013 Apr
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
2015 Nov 3
Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes.
2016 May 17
Phosphorus recovery from biogas slurry by ultrasound/H(2)O(2) digestion coupled with HFO/biochar adsorption process.
2017 Feb
Effect of iron and carbon monoxide on fibrinogenase-like degradation of plasmatic coagulation by venoms of four Crotalus species.
2017 Jan
Patents

Patents

20080188032
44
20090216060
44
6258758
44
US 5206265 A
44
US2385188
44
US3873678
44
US4364871
44
US6881255
44
US6903235
44
US7198668
44
US8071067
44

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Iron oxides black, red and yellow are intended to be used as colourants in feedingstuffs for all animal species without dose or age restriction. The applicant recommends 500–1,200 mg/kg of the additives in complete (and complementary) feedingstuffs as standard dose. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4482/full
Ferric sodium citrate is an additive used in various foods such as baby milk powder, school and hospital food, beverages, cereals and supplements. It is administered orally.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:07:18 UTC 2023
Edited
by admin
on Fri Dec 15 16:07:18 UTC 2023
Record UNII
2UA751211N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERRIC HYDROXIDE
WHO-DD  
Common Name English
IRON HYDROXIDE (FE(OH)3)
Common Name English
HYDRATED IRON SESQUIOXIDE
Common Name English
FERRIC HYDROXIDE GEL
Common Name English
Ferric hydroxide [WHO-DD]
Common Name English
DIIRON TRIOXIDE HYDRATE
Common Name English
Classification Tree Code System Code
WHO-ATC B03AB04
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
WHO-VATC QB03AB04
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
Code System Code Type Description
SMS_ID
100000078937
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
NCI_THESAURUS
C83713
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
PUBCHEM
73964
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
DRUG BANK
DB13423
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
MESH
C021024
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
RXCUI
1428835
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY RxNorm
EVMPD
SUB13843MIG
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
ALTERNATIVE
CAS
1309-33-7
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
FDA UNII
2UA751211N
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
CAS
11113-66-9
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
ALTERNATIVE
WIKIPEDIA
Ferric hydroxide
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
CONCEPT Industrial Aid
ECHA (EC/EINECS)
215-166-1
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
EPA CompTox
DTXSID5051652
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
DRUG CENTRAL
4539
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
EVMPD
SUB13842MIG
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
ECHA (EC/EINECS)
234-346-0
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
ALTERNATIVE
ChEMBL
CHEMBL3707285
Created by admin on Fri Dec 15 16:07:18 UTC 2023 , Edited by admin on Fri Dec 15 16:07:18 UTC 2023
PRIMARY
Related Record Type Details
Structure of FERRIC CATION
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of FERRIC CATION
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