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Details

Stereochemistry ACHIRAL
Molecular Formula C6H4O7.C5H14NO.Fe.3H2O
Molecular Weight 402.153
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERROCHOLINATE

SMILES

O.O.O.[Fe+3].C[N+](C)(C)CCO.[O-]C(=O)CC([O-])(CC([O-])=O)C([O-])=O

InChI

InChIKey=UQSASSBWRKBREL-UHFFFAOYSA-K
InChI=1S/C6H7O7.C5H14NO.Fe.3H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;1-6(2,3)4-5-7;;;;/h1-2H2,(H,7,8)(H,9,10)(H,11,12);7H,4-5H2,1-3H3;;3*1H2/q-1;+1;+3;;;/p-3

HIDE SMILES / InChI
Molecular Formula C5H13NO
Molecular Weight 103.1628
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C6H8O7
Molecular Weight 192.1235
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Fe
Molecular Weight 55.845
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: http://www.druginfosys.com/drug.aspx?drugcode=1316&type=1 | http://www.vademecum.es/medicamento-podertonic+adultos_3181

Ferrocholinate is a chelate prepared by reacting equal quantities of freshly precipitated ferric chloride with choline dihydrogen citrate. Ferrocholinate is used as a source of iron in iron deficiency anemia. Ferrocholinate absorption is increased by simultaneous administration of ascorbic acid. Absorption reduced by antacids, cholestyramine or proton pump inhibitors (omeprazole, pantoprazole, lansoprazole). The following adverse effects may occur: occasionally, gastrointestinal disorders (stomach pain, nausea, constipation or diarrhea) may appear, which usually disappear quickly after the dose is reduced or, if necessary, after treatment discontinuation. Darkness of stool: it is frequently observed during treatment and is safe for the patient. Allergic reactions may occur, also.

Originator

Approval Year

1953
193
Targets

Targets

Primary TargetPharmacologyConditionPotency
Modulator
828
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
FERROLIP

Approved Use

Ferrocholinate is primarily indicated in conditions like iron deficiency anaemia.

Launch Date

1960
Primary
Approved
8429
FERROLIP

Approved Use

Treatment of iron deficiency states and iron deficiency anemia in adults and children, for deficient iron absorption, chronic bleeding or in situations where there is an increase of iron demands such as pregnancy or breastfeeding.

Launch Date

1960
Primary
Approved
8429
FERROLIP

Approved Use

Treatment of iron deficiency states and iron deficiency anemia in adults and children, for deficient iron absorption, chronic bleeding or in situations where there is an increase of iron demands such as pregnancy or breastfeeding.

Launch Date

1960
Sourcing

Sourcing

Vendor/AggregatorIDURL
3B Scientific (Wuhan) Corp
3B3-054251
http://www.3bsc.com/index/pro_info.php?id=92722
BOC Sciences
65228-13-9
https://www.bocsci.com/ferric-choline-citrate-cas-65228-13-9-item-205804.html
PubChem
76966607
https://pubchem.ncbi.nlm.nih.gov/compound/76966607
PubMed

PubMed

TitleDatePubMed
Pediatric use of ferrocholinate.
1962 Jul
Patents

Patents

US20050042270 A1
2
US2575611 A
2

Sample Use Guides

In Vivo Use Guide
Curator's Comment: http://www.ndrugs.com/?s=podertonic%20ni%C3%B1os | https://clicks.co.za/chela-fer_iron-supplement-30-tablets/p/44856 | https://www.aemps.gob.es/cima/pdfs/es/ft/54556/54556_ft.pdf
1 tablet (100 mg) daily Adults daily dose is equivalent to 112.6 mg Fe3. Take this medication preferably a few hours before meals. Duration of treatment depends on nature and severity of iron deficiency.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:56:55 GMT 2023
Edited
by admin
on Fri Dec 15 15:56:55 GMT 2023
Record UNII
LWI5ZJ8WVL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERROCHOLINATE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
FERROLIP
Brand Name English
FERROCHOLINATE [MI]
Common Name English
FERROCHOLINATE [MART.]
Common Name English
Ferrocholinate [WHO-DD]
Common Name English
FERRIC CHOLINE CITRATE
Common Name English
IRON CHOLINE CITRATE COMPLEX
Common Name English
ferrocholinate [INN]
Common Name English
(HYDROGEN CITRATO(3-))TRIAQUOIRON, CHOLINE SALT
Common Name English
ETHANAMINIUM, 2-HYDROXY-N,N,N-TRIMETHYL-, (OC-6-44)-TRIAQUA(2-(HYDROXY-.KAPPA.O)-1,2,3-PROPANETRICARBOXYLATO(4-)-.KAPPA.O1,.KAPPA.O2)FERRATE(1-) (1:1)
Common Name English
FRE-SOL
Brand Name English
Classification Tree Code System Code
CFR 21 CFR 172.370
Created by admin on Fri Dec 15 15:56:55 GMT 2023 , Edited by admin on Fri Dec 15 15:56:55 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C1505
Created by admin on Fri Dec 15 15:56:55 GMT 2023 , Edited by admin on Fri Dec 15 15:56:55 GMT 2023
CONCEPT Dietary Supplement
EVMPD
SUB07612MIG
Created by admin on Fri Dec 15 15:56:55 GMT 2023 , Edited by admin on Fri Dec 15 15:56:55 GMT 2023
PRIMARY
MERCK INDEX
m5335
Created by admin on Fri Dec 15 15:56:55 GMT 2023 , Edited by admin on Fri Dec 15 15:56:55 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C76836
Created by admin on Fri Dec 15 15:56:55 GMT 2023 , Edited by admin on Fri Dec 15 15:56:55 GMT 2023
PRIMARY
INN
890
Created by admin on Fri Dec 15 15:56:55 GMT 2023 , Edited by admin on Fri Dec 15 15:56:55 GMT 2023
PRIMARY
SMS_ID
100000080961
Created by admin on Fri Dec 15 15:56:55 GMT 2023 , Edited by admin on Fri Dec 15 15:56:55 GMT 2023
PRIMARY
CAS
1336-80-7
Created by admin on Fri Dec 15 15:56:55 GMT 2023 , Edited by admin on Fri Dec 15 15:56:55 GMT 2023
PRIMARY
PUBCHEM
46174080
Created by admin on Fri Dec 15 15:56:55 GMT 2023 , Edited by admin on Fri Dec 15 15:56:55 GMT 2023
PRIMARY
FDA UNII
LWI5ZJ8WVL
Created by admin on Fri Dec 15 15:56:55 GMT 2023 , Edited by admin on Fri Dec 15 15:56:55 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-649-7
Created by admin on Fri Dec 15 15:56:55 GMT 2023 , Edited by admin on Fri Dec 15 15:56:55 GMT 2023
PRIMARY
Related Record Type Details
Structure of CHOLINE
PARENT -> SALT/SOLVATE
Structure of FERROCHOLINATE ANHYDROUS
ANHYDROUS->SOLVATE
Structure of FERRIC CATION
PARENT -> SALT/SOLVATE
Structure of ANHYDROUS CITRIC ACID
PARENT -> SALT/SOLVATE
NIH
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