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Details

Stereochemistry ACHIRAL
Molecular Formula C10H21N3O.C6H8O7
Molecular Weight 391.4168
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIETHYLCARBAMAZINE CITRATE

SMILES

OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)C(=O)N1CCN(C)CC1

InChI

InChIKey=PGNKBEARDDELNB-UHFFFAOYSA-N
InChI=1S/C10H21N3O.C6H8O7/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

HIDE SMILES / InChI

Molecular Formula C10H21N3O
Molecular Weight 199.2932
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H8O7
Molecular Weight 192.1235
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including http://filobase.bicpu.edu.in/banocide.pdf

Diethylcarbamazine is used in humans, dogs and cats for the treatment of parasitic infections, including pulmonary eosinophilia, loiasis, and lymphatic filariasis. The exact mechanism of its action is unknown, however some studies showed the involvment of inducible nitric-oxide synthase and the cyclooxygenase pathway. Although there is no information on whether the drug is marketed in the USA and Europe, it is currently used in India.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
BANOCIDE

Approved Use

Used for the treatment of individual patients with certain filarial diseases including tropical pulmonary eosinophilia, loiasis, and lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori.
Curative
BANOCIDE

Approved Use

Used for the treatment of individual patients with certain filarial diseases including tropical pulmonary eosinophilia, loiasis, and lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori.
Curative
BANOCIDE

Approved Use

Used for the treatment of individual patients with certain filarial diseases including tropical pulmonary eosinophilia, loiasis, and lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori.
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
500 ng/mL
150 mg single, oral
dose: 150 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
DIETHYLCARBAMAZINE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
637 ng/mL
150 mg single, oral
dose: 150 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
DIETHYLCARBAMAZINE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
5840 ng × h/mL
150 mg single, oral
dose: 150 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
DIETHYLCARBAMAZINE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
7220 ng × h/mL
150 mg single, oral
dose: 150 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
DIETHYLCARBAMAZINE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
14.6 h
150 mg single, oral
dose: 150 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
DIETHYLCARBAMAZINE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
11.4 h
150 mg single, oral
dose: 150 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
DIETHYLCARBAMAZINE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
6 mg/kg 1 times / day multiple, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, 12 to 69 years
Health Status: unhealthy
Age Group: 12 to 69 years
Sex: M+F
Sources:
Other AEs: Fever, Pruritus...
Other AEs:
Fever (63.6%)
Pruritus (9.1%)
Giddiness (9.1%)
Joint ache (9.1%)
Sources:
2 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 2 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 2 mg/kg, 3 times / day
Sources:
unhealthy, 13 to 46 years
Health Status: unhealthy
Age Group: 13 to 46 years
Sex: M+F
Sources:
Other AEs: Fever, Nausea...
Other AEs:
Fever
Nausea (27.3%)
Vomiting (18.2%)
Abdominal discomfort (9.1%)
Sources:
50 mg multiple, oral
Studied dose
Dose: 50 mg
Route: oral
Route: multiple
Dose: 50 mg
Sources:
unhealthy, 37 years
Health Status: unhealthy
Age Group: 37 years
Sex: M
Sources:
Other AEs: Lymphadenopathy, Papular urticarial eruption...
Other AEs:
Lymphadenopathy (100%)
Papular urticarial eruption (30%)
Proteinuria (10%)
Visual field constriction (20%)
Optic nerve pallor (10%)
Corneal opacity (90%)
Anterior uveitis (10%)
Chorioretinitis (10%)
Sources:
300 mg multiple, topical
Studied dose
Dose: 300 mg
Route: topical
Route: multiple
Dose: 300 mg
Sources:
unhealthy, 40 years
Health Status: unhealthy
Age Group: 40 years
Sex: M
Sources:
Other AEs: Lymphadenopathy, Papular urticarial eruption...
Other AEs:
Lymphadenopathy (100%)
Papular urticarial eruption (70%)
Proteinuria (30%)
Visual field constriction (10%)
Optic nerve pallor (20%)
Corneal opacity (80%)
Anterior uveitis (30%)
Chorioretinitis (30%)
Sources:
6 mg/kg 1 times / day single, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, median age 35 years
Health Status: unhealthy
Age Group: median age 35 years
Sex: M+F
Sources:
Other AEs: Fatigue, Nausea...
Other AEs:
Fatigue (grade 2, 5%)
Nausea (grade 2, 2%)
Vomiting (grade 2, 2%)
Joint pain (grade 2, 2%)
Eye swelling (grade 2, 2%)
Rash (grade 2, 2%)
Dyspnea (grade 2, 2%)
Sources:
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Other AEs: Fever, Headache...
Other AEs:
Fever (69%)
Headache (65%)
Vertigo (57%)
Malaise (49%)
Chills (45%)
Joint pain (40%)
Abdominal pain (37%)
Chest pain (33%)
Nausea (28%)
Neck pain (24%)
Vomiting (16%)
Muscular pain (14%)
Lymph node tenderness (38%)
Epididymal tenderness (34%)
Nodule (15%)
Tinnitus (8%)
Convulsion (2%)
Eruption (<1%)
Shock (<1%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Fever 63.6%
6 mg/kg 1 times / day multiple, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, 12 to 69 years
Health Status: unhealthy
Age Group: 12 to 69 years
Sex: M+F
Sources:
Giddiness 9.1%
6 mg/kg 1 times / day multiple, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, 12 to 69 years
Health Status: unhealthy
Age Group: 12 to 69 years
Sex: M+F
Sources:
Joint ache 9.1%
6 mg/kg 1 times / day multiple, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, 12 to 69 years
Health Status: unhealthy
Age Group: 12 to 69 years
Sex: M+F
Sources:
Pruritus 9.1%
6 mg/kg 1 times / day multiple, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, 12 to 69 years
Health Status: unhealthy
Age Group: 12 to 69 years
Sex: M+F
Sources:
Fever
2 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 2 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 2 mg/kg, 3 times / day
Sources:
unhealthy, 13 to 46 years
Health Status: unhealthy
Age Group: 13 to 46 years
Sex: M+F
Sources:
Vomiting 18.2%
2 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 2 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 2 mg/kg, 3 times / day
Sources:
unhealthy, 13 to 46 years
Health Status: unhealthy
Age Group: 13 to 46 years
Sex: M+F
Sources:
Nausea 27.3%
2 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 2 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 2 mg/kg, 3 times / day
Sources:
unhealthy, 13 to 46 years
Health Status: unhealthy
Age Group: 13 to 46 years
Sex: M+F
Sources:
Abdominal discomfort 9.1%
2 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 2 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 2 mg/kg, 3 times / day
Sources:
unhealthy, 13 to 46 years
Health Status: unhealthy
Age Group: 13 to 46 years
Sex: M+F
Sources:
Anterior uveitis 10%
50 mg multiple, oral
Studied dose
Dose: 50 mg
Route: oral
Route: multiple
Dose: 50 mg
Sources:
unhealthy, 37 years
Health Status: unhealthy
Age Group: 37 years
Sex: M
Sources:
Chorioretinitis 10%
50 mg multiple, oral
Studied dose
Dose: 50 mg
Route: oral
Route: multiple
Dose: 50 mg
Sources:
unhealthy, 37 years
Health Status: unhealthy
Age Group: 37 years
Sex: M
Sources:
Optic nerve pallor 10%
50 mg multiple, oral
Studied dose
Dose: 50 mg
Route: oral
Route: multiple
Dose: 50 mg
Sources:
unhealthy, 37 years
Health Status: unhealthy
Age Group: 37 years
Sex: M
Sources:
Proteinuria 10%
50 mg multiple, oral
Studied dose
Dose: 50 mg
Route: oral
Route: multiple
Dose: 50 mg
Sources:
unhealthy, 37 years
Health Status: unhealthy
Age Group: 37 years
Sex: M
Sources:
Lymphadenopathy 100%
50 mg multiple, oral
Studied dose
Dose: 50 mg
Route: oral
Route: multiple
Dose: 50 mg
Sources:
unhealthy, 37 years
Health Status: unhealthy
Age Group: 37 years
Sex: M
Sources:
Visual field constriction 20%
50 mg multiple, oral
Studied dose
Dose: 50 mg
Route: oral
Route: multiple
Dose: 50 mg
Sources:
unhealthy, 37 years
Health Status: unhealthy
Age Group: 37 years
Sex: M
Sources:
Papular urticarial eruption 30%
50 mg multiple, oral
Studied dose
Dose: 50 mg
Route: oral
Route: multiple
Dose: 50 mg
Sources:
unhealthy, 37 years
Health Status: unhealthy
Age Group: 37 years
Sex: M
Sources:
Corneal opacity 90%
50 mg multiple, oral
Studied dose
Dose: 50 mg
Route: oral
Route: multiple
Dose: 50 mg
Sources:
unhealthy, 37 years
Health Status: unhealthy
Age Group: 37 years
Sex: M
Sources:
Visual field constriction 10%
300 mg multiple, topical
Studied dose
Dose: 300 mg
Route: topical
Route: multiple
Dose: 300 mg
Sources:
unhealthy, 40 years
Health Status: unhealthy
Age Group: 40 years
Sex: M
Sources:
Lymphadenopathy 100%
300 mg multiple, topical
Studied dose
Dose: 300 mg
Route: topical
Route: multiple
Dose: 300 mg
Sources:
unhealthy, 40 years
Health Status: unhealthy
Age Group: 40 years
Sex: M
Sources:
Optic nerve pallor 20%
300 mg multiple, topical
Studied dose
Dose: 300 mg
Route: topical
Route: multiple
Dose: 300 mg
Sources:
unhealthy, 40 years
Health Status: unhealthy
Age Group: 40 years
Sex: M
Sources:
Anterior uveitis 30%
300 mg multiple, topical
Studied dose
Dose: 300 mg
Route: topical
Route: multiple
Dose: 300 mg
Sources:
unhealthy, 40 years
Health Status: unhealthy
Age Group: 40 years
Sex: M
Sources:
Chorioretinitis 30%
300 mg multiple, topical
Studied dose
Dose: 300 mg
Route: topical
Route: multiple
Dose: 300 mg
Sources:
unhealthy, 40 years
Health Status: unhealthy
Age Group: 40 years
Sex: M
Sources:
Proteinuria 30%
300 mg multiple, topical
Studied dose
Dose: 300 mg
Route: topical
Route: multiple
Dose: 300 mg
Sources:
unhealthy, 40 years
Health Status: unhealthy
Age Group: 40 years
Sex: M
Sources:
Papular urticarial eruption 70%
300 mg multiple, topical
Studied dose
Dose: 300 mg
Route: topical
Route: multiple
Dose: 300 mg
Sources:
unhealthy, 40 years
Health Status: unhealthy
Age Group: 40 years
Sex: M
Sources:
Corneal opacity 80%
300 mg multiple, topical
Studied dose
Dose: 300 mg
Route: topical
Route: multiple
Dose: 300 mg
Sources:
unhealthy, 40 years
Health Status: unhealthy
Age Group: 40 years
Sex: M
Sources:
Dyspnea grade 2, 2%
6 mg/kg 1 times / day single, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, median age 35 years
Health Status: unhealthy
Age Group: median age 35 years
Sex: M+F
Sources:
Eye swelling grade 2, 2%
6 mg/kg 1 times / day single, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, median age 35 years
Health Status: unhealthy
Age Group: median age 35 years
Sex: M+F
Sources:
Joint pain grade 2, 2%
6 mg/kg 1 times / day single, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, median age 35 years
Health Status: unhealthy
Age Group: median age 35 years
Sex: M+F
Sources:
Nausea grade 2, 2%
6 mg/kg 1 times / day single, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, median age 35 years
Health Status: unhealthy
Age Group: median age 35 years
Sex: M+F
Sources:
Rash grade 2, 2%
6 mg/kg 1 times / day single, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, median age 35 years
Health Status: unhealthy
Age Group: median age 35 years
Sex: M+F
Sources:
Vomiting grade 2, 2%
6 mg/kg 1 times / day single, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, median age 35 years
Health Status: unhealthy
Age Group: median age 35 years
Sex: M+F
Sources:
Fatigue grade 2, 5%
6 mg/kg 1 times / day single, oral
Studied dose
Dose: 6 mg/kg, 1 times / day
Route: oral
Route: single
Dose: 6 mg/kg, 1 times / day
Sources:
unhealthy, median age 35 years
Health Status: unhealthy
Age Group: median age 35 years
Sex: M+F
Sources:
Muscular pain 14%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Nodule 15%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Vomiting 16%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Convulsion 2%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Neck pain 24%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Nausea 28%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Chest pain 33%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Epididymal tenderness 34%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Abdominal pain 37%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Lymph node tenderness 38%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Joint pain 40%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Chills 45%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Malaise 49%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Vertigo 57%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Headache 65%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Fever 69%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Tinnitus 8%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Eruption <1%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Shock <1%
8 mg/kg 3 times / day multiple, oral
Studied dose
Dose: 8 mg/kg, 3 times / day
Route: oral
Route: multiple
Dose: 8 mg/kg, 3 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: M+F
Sources:
Overview

Overview

OverviewOther

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
no [Activation >10 uM]
no
no
no
no
no
yes [Inhibition 10 uM]
yes [Inhibition 10 uM]
yes
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
likely
likely
no
no (co-administration study)
Comment: Coadministration of refampicin/ketoconazole did not affect the exposure of diethylcarbamazine.
no
no (co-administration study)
Comment: Coadministration of refampicin/ketoconazole did not affect the exposure of diethylcarbamazine.
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Lymphatic filariasis.
2003-05-16
Strategic options for global lymphatic filariasis elimination.
2003-05
Ensuring supplies of quality diethylcarbamazine citrate (DEC).
2003-05
Factors responsible for coverage and compliance in mass drug administration during the programme to eliminate lymphatic filariasis in the East Godavari District, South India.
2003-04
Long-term population migration: an important aspect to be considered during mass drug administration for elimination of lymphatic filariasis.
2003-04
Case report: intraocular localization of Mansonella perstans in a patient from south Chad.
2003-03-11
Relationships between Wuchereria bancrofti microfilaria counts in human blood and parasite uptake and maturation in Culex pipiens, with observations on the effects of diethylcarbamazine treatment on these parameters.
2003-03
Setaria cervi: in vitro released collagenases and their inhibition by Wuchereria bancrofti infected sera.
2003-03
Serum immunoglobulin G4 antibodies to the recombinant antigen, Ll-SXP-1, are highly specific for Loa loa infection.
2003-01-01
Long-term follow-up of treatment with diethylcarbamazine on anti-filarial IgG4: dosage, compliance, and differential patterns in adults and children.
2003-01
Targeting apoptotic signalling pathway and pro-inflammatory cytokine expression as therapeutic intervention in TPE induced lung damage.
2003
A comparison of the efficacy of single doses of albendazole, ivermectin, and diethylcarbamazine alone or in combinations against Ascaris and Trichuris spp.
2003
Major progress toward eliminating lymphatic filariasis.
2002-12-05
Mass treatment to eliminate filariasis in Papua New Guinea.
2002-12-05
Modelling the epidemiology, transmission and control of lymphatic filariasis.
2002-12
Use of floating layers of polystyrene beads to control populations of the filaria vector Culex quinquefasciatus.
2002-12
Cost-effectiveness of the use of vector control and mass drug administration, separately or in combination, against lymphatic filariasis.
2002-12
Operational issues in the control of the vectors of Brugia.
2002-12
Progress towards, and challenges for, the elimination of filariasis from Pacific-island communities.
2002-12
Detection of Onchocerca volvulus infection in low prevalence areas: a comparison of three diagnostic methods.
2002-12
Bancroftian filariasis: clinical parasitologic and serologic evaluation after 4 years applying two antifilarial regimens.
2002-12
Targeting of children in filariasis mass drug administration.
2002-11-02
[Asthenoscopic problems with a subconjunctival worm].
2002-11
Neoplastic change in Onchocerca volvulus and its relation to ivermectin treatment.
2002-11
Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells.
2002-11
Prevalence of diurnally subperiodic bancroftian filariasis among the Nicobarese in Andaman and Nicobar Islands, India: effect of age and gender.
2002-11
Red blood cell antioxidant levels in Wuchereria bancrofti infection.
2002-10
Microfilaria in a thyroid nodule which resolved on treatment.
2002-10
Treatment of Brugia timori and Wuchereria bancrofti infections in Indonesia using DEC or a combination of DEC and albendazole: adverse reactions and short-term effects on microfilariae.
2002-10
Statistical issues in the assessment of the evidence for an interaction between factors in epilepsy trials.
2002-09-30
The pharmacokinetics, safety and tolerability of the co-administration of diethylcarbamazine and albendazole.
2002-09
The influence of the mass administration of diethylcarbamazine, alone or with albendazole, on the prevalence of filarial antigenaemia.
2002-09
The effect of six rounds of single dose mass treatment with diethylcarbamazine or ivermectin on Wuchereria bancrofti infection and its implications for lymphatic filariasis elimination.
2002-09
Efficacy and sustainability of a footcare programme in preventing acute attacks of adenolymphangitis in Brugian filariasis.
2002-09
The impact of single-dose diethylcarbamazine treatment of bancroftian filariasis in a low-endemicity setting in Egypt.
2002-08
New goals set for filariasis elimination in India.
2002-07
Mass drug administration to treat lymphatic filariasis.
2002-06-01
Efficacy of co-administration of albendazole and diethylcarbamazine against geohelminthiases: a study from South India.
2002-06
Case 1-2002: Loa loa.
2002-05-30
Electron microscopic and molecular identification of Wolbachia endosymbionts from Onchocerca lupi: implications for therapy.
2002-05-30
Young male with pancytopenia: an unusual cause.
2002-05
Anthelmintics: a review.
2002-04-20
[Toxocariasis in Poznan region, Poland, in years 1990-2000].
2002
[Technical measures of filariasis elimination in Tengzhou City].
2002
Carbamazepine-provoked hepatotoxicity and possible aetiopathological role of glutathione in the events. Retrospective review of old data and call for new investigation.
2002
Subconjunctival Loa Loa worm: case report.
2002
Compliance with the mass chemotherapy program for lymphatic filariasis.
2001-12
Lymphatic filariasis in kenya since 1910, and the prospects for its elimination: a review.
2001-11
Mass DEC campaign for filariasis in a hyper endemic district of West Bengal.
2001-09
A brief introduction to the research achievement on the strategy and technical measures for interrupting the transmission of lymphatic filariasis in China.
2001

Sample Use Guides

Lymphatic filariasis: 6 mg/kg daily for 12 days administered orally, preferably in divided doses after meals (W. bancrofti infection); 3-6 mg/kg daily for 6-12 days administered orally, preferably in divided doses after meals (B. malayi and B. timori infections). Tropical pulmonary eosinophilia: a dose of 8 mg/kg daily for 14 days repeated, as necessary, if symptoms return.
Route of Administration: Oral
Larvae of nocturnally subperiodic Brugia malayi was inhibited under incubation with diethylcarbamazine at concentration of 10(-5) M.
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:46:03 GMT 2025
Edited
by admin
on Mon Mar 31 17:46:03 GMT 2025
Record UNII
OS1Z389K8S
Record Status Validated (UNII)
Record Version
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Name Type Language
DIETHYLCARBAMAZINE CITRATE
EP   GREEN BOOK   HSDB   MART.   MI   ORANGE BOOK   USP   USP-RS   WHO-DD  
Common Name English
HETRAZAN
Preferred Name English
DIETHYLCARBAMAZINE CITRATE [GREEN BOOK]
Common Name English
LOXURAN
Common Name English
DIETHYLCARBAMAZINE CITRATE [USP IMPURITY]
Common Name English
1-PIPERAZINECARBOXAMIDE, N,N-DIETHYL-4-METHYL-, 2-HYDROXY-1,2,3-PROPANETRICARBOXYLATE
Systematic Name English
DIETHYLCARBAMAZINI DIHYDROGENOCITRAS [WHO-IP LATIN]
Common Name English
NSC-80513
Code English
DIETHYLCARBAMAZINE CITRATE [USP-RS]
Common Name English
Diethylcarbamazine citrate [WHO-DD]
Common Name English
DIETHYLCARBAMAZINE CITRATE [MART.]
Common Name English
DIETHYLCARBAMAZINE CITRATE [JAN]
Common Name English
DIETHYLCARBAMAZINE DIHYDROGEN CITRATE [WHO-IP]
Common Name English
DIETHYLCARBAMAZINE CITRATE [ORANGE BOOK]
Common Name English
DIETHYLCARBAMAZINE CITRATE [MI]
Common Name English
DIETHYLCARBAMAZINE CITRATE [HSDB]
Common Name English
ETHYLAMINOAZINE CITRATE
Common Name English
DIETHYLCARBAMAZINE CITRATE [USP MONOGRAPH]
Common Name English
N,N-Diethyl-4-methyl-1-piperazinecarboxamide citrate (1:1)
Systematic Name English
Classification Tree Code System Code
CFR 21 CFR 520.622B
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
NCI_THESAURUS C250
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
CFR 21 CFR 520.622
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
CFR 21 CFR 520.622A
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
CFR 21 CFR 520.622C
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
Code System Code Type Description
EPA CompTox
DTXSID4045555
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
DRUG BANK
DBSALT000975
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
NSC
80513
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
FDA UNII
OS1Z389K8S
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
NCI_THESAURUS
C65379
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
ECHA (EC/EINECS)
216-696-6
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
RS_ITEM_NUM
1193006
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
MERCK INDEX
m4398
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY Merck Index
ChEMBL
CHEMBL684
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
CAS
1642-54-2
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
DIETHYLCARBAMAZINE DIHYDROGEN CITRATE
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY Description: A white, crystalline powder; odourless or almost odourless.Solubility: Very soluble in water; soluble in 35 parts of ethanol (~750 g/l) TS; practically insoluble in ether R.Category: Filaricide.Storage: Diethylcarbamazine dihydrogen citrate should be kept in a tightly closed container, protected from light.Additional information: Diethylcarbamazine dihydrogen citrate is hygroscopic; it has an acid and bitter taste. Even in the absenceof light, Diethylcarbamazine dihydrogen citrate is gradually degraded on exposure to a humid atmosphere, the decompositionbeing faster at higher temperatures.Definition: Diethylcarbamazine dihydrogen citrate contains not less than 98.0% and not more than 101.0% of C10H21N3O,C6H8O7, calculated with reference to the anhydrous substance.
EVMPD
SUB01686MIG
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
RXCUI
203175
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY RxNorm
DAILYMED
OS1Z389K8S
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
SMS_ID
100000087926
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
HSDB
6421
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
PUBCHEM
15432
Created by admin on Mon Mar 31 17:46:03 GMT 2025 , Edited by admin on Mon Mar 31 17:46:03 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
IMPURITY -> PARENT
IMPURITY -> PARENT
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ACTIVE MOIETY