N-Methylpiperazine

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H12N2
Molecular Weight	100.1622
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCNCC1

InChI

InChIKey=PVOAHINGSUIXLS-UHFFFAOYSA-N

InChI=1S/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H3

HIDE SMILES / InChI

Molecular Formula	C5H12N2
Molecular Weight	100.1622
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
[Synthesis and pharmacological activity of amides and ozonolysis product of maleopimaric acid].	2011-02-15	21317950
Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells.	2010-11-15	20932753
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds.	2010-09-15	20667740
In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.	2010-09-14	20856868
Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors.	2010-09-09	20690647
Chalcogenides of the aminomethylphosphines derived from 1-methylpiperazine, 1-ethylpiperazine and morpholine: NMR, DFT and structural studies for determination of electronic and steric properties of the phosphines.	2010-08-28	20617235
catena-Poly[(S)-2-methyl-piperazine-1,4-diium [[trichloridobismuthate(III)]-di-μ-chlorido]].	2010-08-11	21588498
Determination of individual proton affinities of ofloxacin from its UV-Vis absorption, fluorescence and charge-transfer spectra: effect of inclusion in beta-cyclodextrin on the proton affinities.	2010-08-05	20666527
[Synthesis, modifications, and antimicrobial activity of the methylpiperazinyl amides of triterpenic acids].	2010-07-21	20644598
Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.	2010-06-08	20544024
A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products.	2010-05	20305283
Streamlined, automated protocols for the production of milligram quantities of untagged recombinant human cyclophilin-A (hCypA) and untagged human proliferating cell nuclear antigen (hPCNA) using AKTAxpress.	2010-05	19995609
Synthesis and antimicrobial activities of some new 1,2,3-triazole derivatives.	2010-04-08	20428053
Conjugate addition of nucleophiles to the vinyl function of 2-chloro-4-vinylpyrimidine derivatives.	2010-03-19	20336026
Sulfonamide-1,2,4-thiadiazole derivatives as antifungal and antibacterial agents: synthesis, biological evaluation, lipophilicity, and conformational studies.	2010-02	20118573
Detection of nitric oxide in tissue samples by ESI-MS.	2010-02	20098762
Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.	2010-01-28	20017493
Imatinibium dipicrate.	2010-01-20	21579830
Theoretical and experimental studies of the isomeric protonation in solution for a prototype aliphatic ring containing two nitrogens.	2010-01-14	19994881
Novel imatinib derivatives with altered specificity between Bcr-Abl and FMS, KIT, and PDGF receptors.	2010-01	19950162
Solution structure of a covalently bound pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole hybrid to a 10mer DNA duplex.	2009-12-29	19911838
Proteomics: challenges, techniques and possibilities to overcome biological sample complexity.	2009-12-08	20948568
[2-(4-Methyl-piperazin-1-ylmeth-yl)phen-yl]diphenyl-phosphane.	2009-11-25	21578904
Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT.	2009-09-30	19789626
Nilotinib: optimal therapy for patients with chronic myeloid leukemia and resistance or intolerance to imatinib.	2009-09-21	19920925
Regioselective reaction: synthesis and pharmacological study of Mannich bases containing ibuprofen moiety.	2009-09	19427713
Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities.	2009-07	19167136
Discovery of substituted N'-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay.	2009-05-15	19369076
Manipulation of fluorescent and colorimetric changes of fluorescein derivatives and applications for sensing silver ions.	2009-03-14	19240884
Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities.	2009-03	18676062
The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2).	2009-02-24	19236722
Development and targeted use of nilotinib in chronic myeloid leukemia.	2009-02-06	19920910
Synthesis and spectral characterization of a new class of N-(N-methylpiperazinoacetyl)-2,6-diarylpiperidin-4-ones: antimicrobial, analgesic and antipyretic studies.	2009-02	18485539
Structure elucidation of thioketone analogues of sildenafil detected as adulterants in herbal aphrodisiacs.	2009-01-15	19042103
Hoechst 33342: the dye that enabled differentiation of living X-and Y-chromosome bearing mammalian sperm.	2009-01-01	18952273
The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.	2009	19240808
Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.	2008-10-23	18811133
Improved proteome coverage by using iTRAQ labelling and peptide OFFGEL fractionation.	2008-10-13	18851748
Refining targeted therapies in chronic myeloid leukemia: development and application of nilotinib, a step beyond imatinib.	2008-10-01	21127752
Copper(I) cyanide networks: synthesis, structure, and luminescence behavior. Part 2. Piperazine ligands and hexamethylenetetramine.	2008-08-04	18597424
Use of N-methylpiperazine for the preparation of piperazine-based unsymmetrical bis-ureas as anti-HIV agents.	2008-07	18383064
Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry.	2008-06-24	18567304
Morpholine-based immonium and halogenoamidinium salts as coupling reagents in Peptide synthesis1.	2008-04-04	18321124
3-(4-Methyl-piperazin-1-yl)isobenzofuran-1(3H)-one.	2008-04-02	21202272
Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates.	2008-01	20390097
Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation.	2008	19030106
N-Methyl-piperazinediium penta-chloridoanti-monate(III) monohydrate.	2007-12-12	21200500
NS-187 (INNO-406), a Bcr-Abl/Lyn dual tyrosine kinase inhibitor.	2007-11-14	19662183
Synthesis of o-sulfamidotriazobenzenes from 1,1'-sulfonylbis(benzotriazole).	2007-07-20	17583958
Precise protein quantification based on peptide quantification using iTRAQ.	2007-06-21	17584939

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:36:17 GMT 2025` Edited by `admin` on `Mon Mar 31 19:36:17 GMT 2025`
Record UNII	B92I95EL9Q
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

N-Methylpiperazine

Systematic Name

English

Cyclizine related ocmpound A

Preferred Name

English

Piperazine, 1-methyl-

Systematic Name

English

1-Methylpiperazine

Systematic Name

English

1-Methylpiperazine [USP IMPURITY]

Common Name

English

Cyclizine related ocmpound A [USP-RS]

Common Name

English

NSC-30195

Code

English

NSC-30675

Code

English

1-Methyl-1,4-piperazine

Common Name

English

Diethylcarbamazine citrate impurity A [EP IMPURITY]

Common Name

English

Code System Code Type Description

WIKIPEDIA

Methylpiperazine