ANHYDROUS TRISODIUM CITRATE

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H5O7.3Na
Molecular Weight	258.069
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ANHYDROUS TRISODIUM CITRATE

Structure Search

SMILES

[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

InChIKey=HRXKRNGNAMMEHJ-UHFFFAOYSA-K

InChI=1S/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H5O7
Molecular Weight	189.0997
Charge	-3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.rxlist.com/urocit-drug.htm
Curator's Comment: Description was created based on several sources, including http://www.adm.com/en-US/worldwide/australia/Documents/Potassium%20Citrate%20AU.pdf | https://noshly.com/additive/e332/acidity-regulator-plus/332/#.WUp-1uvyjIU

Potassium citrate is indicated for the management of renal tubular acidosis with calcium stones, hypocitraturic calcium oxalate nephrolithiasis of any etiology, uric acid lithiasis with or without calcium stones. WhenPotassium citrate is given orally, the metabolism of absorbed citrate produces an alkaline load. The induced alkaline load in turn increases urinary pH and raises urinary citrate by augmenting citrate clearance without measurably altering ultrafilterable serum citrate. Thus, potassium citrate therapy appears to increase urinary citrate principally by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. Potassium citrate is used as a food additive (E 332) to regulate acidity.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
response to acidic pH 16 Target ID: GO:0010447 Sources: https://www.rxlist.com/urocit-drug.htm	Interacts 323

Conditions

Condition	Modality	Targets	Highest Phase	Product
Renal tubular acidosis 16 Sources: https://www.rxlist.com/urocit-drug.htm#indications_dosage	Primary		Approved 8429	UROCIT-K Approved Use Urocit®-K is a citrate salt of potassium indicated for the management of: • Renal tubular acidosis (RTA) with calcium stones • Hypocitraturic calcium oxalate nephrolithiasis of any etiology • Uric acid lithiasis with or without calcium stones Launch Date 4.94121615E11
Nephrolithiasis 23 Sources: https://www.rxlist.com/urocit-drug.htm#indications_dosage	Primary		Approved 8429	UROCIT-K Approved Use Urocit®-K is a citrate salt of potassium indicated for the management of: • Renal tubular acidosis (RTA) with calcium stones • Hypocitraturic calcium oxalate nephrolithiasis of any etiology • Uric acid lithiasis with or without calcium stones Launch Date 4.94121615E11

Doses

Dose	Population	Adverse events
540 mg 1 times / day multiple, oral Recommended Dose: 540 mg, 1 times / day Route: oral Route: multiple Dose: 540 mg, 1 times / day Co-administed with:: Thiamin oral 1.1 mg Arginine oral 1240 mg caffeine oral 52 mg Sources: https://pubmed.ncbi.nlm.nih.gov/14646190 Page: p.2326	healthy, 24-59 n = 16 Health Status: healthy Age Group: 24-59 Sex: M+F Population Size: 16 Sources: https://pubmed.ncbi.nlm.nih.gov/14646190 Page: p.2326	Sources: https://pubmed.ncbi.nlm.nih.gov/14646190 Page: p.2326

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY41878	https://www.001chemical.com/chem/77-92-9
3B Scientific (Wuhan) Corp	3B1-00227	http://www.3bsc.com/index/pro_info.php?id=20439
AA Blocks	AA0038YF	http://www.aablocks.com/goods/Goods/detail?id=AA0038YF
AK Scientific, Inc. (AKSCI)	K376	http://www.aksci.com/item_detail.php?cat=K376
Aaron Chemicals	AR0039Q7	http://www.aaronchem.com/77-92-9
AbMole Bioscience	M6610	http://www.abmole.com/products/citric-acid.html
Acadechem	ACDS-021188	http://www.acadechemical.com/product/95887
Aceschem	ACS015658	https://www.aceschem.com/catalog/77-92-9.html
Achemica	ACMC-209pcr	http://www.achemica.com/prodinfo/?id=131549
Achemtek	0104-042098	http://www.achemtek.com/6080-58-6
Achemtek	0104-006324	http://www.achemtek.com/77-92-9
Acorn PharmaTech	ACN-046876	http://www.acornpharmatech.com/
Acros Organics	AC110450010	https://www.fishersci.com/shop/products/citric-acid-anhydrous-99-pure-acros-organics-2/AC110450010
Acros Organics	AC110450050	https://www.fishersci.com/shop/products/citric-acid-anhydrous-99-pure-acros-organics/AC110450050
Acros Organics	AC110450250	https://www.fishersci.com/shop/products/citric-acid-anhydrous-99-pure-acros-organics/AC110450250
Acros Organics	AC220340025	https://www.fishersci.com/shop/products/citric-acid-anhydrous-p-a-acros-organics-2/AC220340025
Acros Organics	AC220341000	https://www.fishersci.com/shop/products/citric-acid-anhydrous-p-a-acros-organics/AC220341000
Alfa Aesar	36664	https://www.alfa.com/en/catalog/036664/
Alfa Aesar	A10395	https://www.alfa.com/en/catalog/A10395/
Alfa Chemistry	AP77929-A	https://reagents.alfa-chemistry.com/product/citric-acid-anhydrous-cas-77-92-9-16525.html
Alfa Chemistry	AP77929-B	https://reagents.alfa-chemistry.com/product/citric-acid-cas-77-92-9-16526.html
Alfa Chemistry	AP77929-C	https://reagents.alfa-chemistry.com/product/citric-acid-cas-77-92-9-16527.html
Alfa Chemistry	77-92-9	https://www.alfa-chemistry.com/citric-acid-cas-77-92-9-item-293668.htm
Alichem	490002446	http://www.alichem.com/en/products/77-92-9.html
Angene	AGN-PC-00UNT2	http://www.angenechemical.com/productshow/AGN-PC-00UNT2.html
Anward	ANW-37129	http://www.anward.com/pro_result/22246
Anward	ANW-44011	http://www.anward.com/pro_result/30462
ApexBio Technology	B7297	http://www.apexbt.com/citric-acid-30358.html
Ark Pharm	AK116143	http://www.arkpharminc.com/products/77-92-9.html
Aurum Pharmatech LLC	NE10694	http://www.Aurumpharmatech.com/Product/ProductDetails/NE10694
Aurum Pharmatech LLC	T8019	http://www.Aurumpharmatech.com/Product/ProductDetails/T8019
Avantor Inc	101182-834	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101182-834
Avantor Inc	200000-234	https://us.vwr.com/store/product/7513960/citric-acid-anhydrous-99-pure
Avantor Inc	200006-068	https://us.vwr.com/store/product/7517749/citric-acid-anhydrous-99-5-for-analysis
Avantor Inc	200004-122	https://us.vwr.com/store/product/7521094/citric-acid
Avantor Inc	101094-638	https://us.vwr.com/store/product/7889380/citric-acid
BLD Pharm	BD34933	http://www.bldpharm.com/products/77-92-9.html
BOC Sciences	287389-42-8	https://isotope.bocsci.com/product/citric-acid-13c6-cas-287389-42-8-344017.html
BOC Sciences	147664-83-3	https://www.bocsci.com/citric-acid-2-2-4-4-d4-cas-147664-83-3-item-349846.html
BioCrick	BCN5374	http://www.biocrick.com/Citric-acid-BCN5374.html
BioSynth	J-520099	https://www.biosynth.com/en/products/all-products/products/J-520099.html
BroadPharm	BP-31028	http://www.broadpharm.com/products/BP-31028/
CSNpharm	CSN19871	https://www.csnpharm.com/products/citric-acid.html
Capot Chemical	20283	http://www.capotchem.com/en/20283.htm
Capot Chemical	PubChem20283	http://www.capotchem.com/en/20283.htm
Chem Scene	CS-6965	http://www.chemscene.com/77-92-9.html
ChemFaces	CFN98551	http://www.chemfaces.com/natural/Citric-acid-CFN98551.html
ChemMol	1201556	http://www.chemmol.com/chemmol/1201556.html
ChemMol	49416728	http://www.chemmol.com/chemmol/49416728.html
ChemMol	99151469	http://www.chemmol.com/chemmol/99151469.html
Chemspace	CSSB00000181717	https://chem-space.com/CSSB00000181717
Clearsynth	CS-T-51162	https://www.clearsynth.com/en/CST51162.html
DC Chemicals	DCW-004	http://www.dcchemicals.com//product_show-Citric_acid.html
Enamine	Z56754862	https://www.enaminestore.com/catalog/Z56754862
Finetech	FT-0665073	http://www.finetechnology-ind.com/prod/detail/pub/147664-83-3.html
Finetech	FT-0623957	http://www.finetechnology-ind.com/prod/detail/pub/77-92-9.html
Finetech	FT-0728530	http://www.finetechnology-ind.com/prod/detail/pub/89853-01-0.html
Fisher Chemical	A9401	https://www.fishersci.com/shop/products/citric-acid-anhydrous-crystalline-certified-acs-fisher-chemical-3/p-92702
Fisher Chemical	A940250LB	https://www.fishersci.com/shop/products/citric-acid-anhydrous-crystalline-certified-acs-fisher-chemical-3/p-92702
Fisher Chemical	A940500	https://www.fishersci.com/shop/products/citric-acid-anhydrous-crystalline-certified-acs-fisher-chemical-3/p-92702
Fisher Chemical	A95250LB	https://www.fishersci.com/shop/products/citric-acid-anhydrous-crystalline-usp-fisher-chemical-2/p-92713
Fisher Chemical	A953	https://www.fishersci.com/shop/products/citric-acid-anhydrous-crystalline-usp-fisher-chemical-2/p-92713
Glentham Life Sciences	GV4009	http://www.glentham.com/products/product/GV4009/
Hairui	HR132047	http://www.hairuichem.com/en/product/77-92-9.html
LGC Standards	LGCFOR0988.00	https://www.lgcstandards.com/US/en/p/LGCFOR0988.00
LGC Standards	MM0988.00	https://www.lgcstandards.com/US/en/p/MM0988.00
Lab Network	LN00194688	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00194688
Matrix Scientific	99590	https://www.matrixscientific.com/099590.html
MedChem Express	HY-N1428	https://www.medchemexpress.com/Citric_acid.html
Molcore	MC41878	https://www.molcore.com/product/77-92-9
MuseChem	I008019	https://www.musechem.com/product/I008019.html
MuseChem	M004236	https://www.musechem.com/product/M004236.html
MuseChem	M004583	https://www.musechem.com/product/M004583.html
MuseChem	M018269	https://www.musechem.com/product/M018269.html
MuseChem	M022848	https://www.musechem.com/product/M022848.html
Oakwood	102336	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=171585&ExtHyperLink=1
Oakwood	102677	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=172886&ExtHyperLink=1
Oakwood	102678	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=172887&ExtHyperLink=1
Oakwood	102679	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=172888&ExtHyperLink=1
Oakwood	44712	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=38587&ExtHyperLink=1
Otava	2957227	https://search.otavachemicals.com/#!/search?query=2957227&type=code&base=dbb
Parchem	26823	http://www.parchem.com/chemical-supplier-distributor/Citric-Acid-Anhydrous--016823.aspx
Parchem	26824	http://www.parchem.com/chemical-supplier-distributor/Citric-Acid-Aqueous-Solution-Food-Grade--016824.aspx
Parchem	10060	http://www.parchem.com/chemical-supplier-distributor/Citric-Acid-Industrial-Grade--000060.aspx
Parchem	19767	http://www.parchem.com/chemical-supplier-distributor/citric-acid-Fragrance-Grade--009767.aspx
R&D Chemicals	714	http://www.rdchemicals.com/chemicals.php?mode=details&mol_id=7635
Renno Tech	RL05015	http://www.rennotech.com/product_show.asp?id=5264
Sigma-Aldrich	05-4960_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/054960?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	251275_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/251275?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	27109_SIGALD	https://www.sigmaaldrich.com/catalog/product/sigald/27109?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	27487_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/27487?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	1134368_USP	https://www.sigmaaldrich.com/catalog/product/usp/1134368?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S005531	http://www.sinfoobiotech.com/product/1008929
Smolecule	S602574	https://www.smolecule.com/products/s602574
TCI (Tokyo Chemical Industry)	C1949	http://www.tcichemicals.com/eshop/en/us/commodity/C1949/index.html
THE BioTek	bt-458701	https://www.thebiotek.com/product/others/bt-458701
Tocris	3160	https://www.tocris.com/products/citric-acid_3160
VladaChem	VL141418	https://www.vladachem.com/product.php?products=77-92-9
VladaChem	VL162337	https://www.vladachem.com/product.php?products=77-92-9
VladaChem	VL167489	https://www.vladachem.com/product.php?products=77-92-9
abcr GmbH	AB115018	http://www.abcr.com/shop/en/AB115018
abcr GmbH	AB208170	http://www.abcr.com/shop/en/AB208170
abcr GmbH	AB355095	http://www.abcr.com/shop/en/AB355095
eNovation Chemicals	D512502	http://www.enovationchem.com/productDetails.asp?productID=D512502
eNovation Chemicals	D680259	https://www.enovationchem.com/ProductDetails.asp?ProductID=D680259
eNovation Chemicals	D785577	https://www.enovationchem.com/ProductDetails.asp?ProductID=D785577
eNovation Chemicals	Y1044001	https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1044001
iChemical	EBD2197796	http://www.ichemical.com/products/77-92-9.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule	MCULE-7981253226	https://mcule.com/MCULE-7981253226/

PubMed

Title	Date	PubMed
Comparative efficacy of "specific" potassium citrate therapy versus conservative management in nephrolithiasis of mild to moderate severity.	1985 Oct	3897582
Renal hypouricemia due to enhanced tubular secretion of urate associated with urolithiasis: successful treatment of urolithiasis by alkalization of urine K+, Na(+)-citrate.	1993	8302413
[Therapeutic use of potassium citrate].	2001	11475849
Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.	2013 Jun	22954530

Patents

Sample Use Guides

In Vivo Use Guide

Objective: To restore normal urinary citrate (greater than 320 mg/day and as close to the normal mean of 640 mg/day as possible), and to increase urinary pH to a level of 6.0 to 7.0. • Severe hypocitraturia (urinary citrate < 150 mg/day): therapy should be initiated at 60 mEq per day; a dose of 30 mEq two times per day or 20 mEq three times per day with meals or within 30 minutes after meals or bedtime snack • Mild to moderate hypocitraturia (urinary citrate >150 mg/day): therapy should be initiated at 30 mEq per day; a dose of 15 mEq two times per day or 10 mEq three times per day with meals or within 30 minutes after meals or bedtime snack

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:32:11 UTC 2023` Edited by `admin` on `Fri Dec 15 15:32:11 UTC 2023`
Record UNII	RS7A450LGA
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ANHYDROUS TRISODIUM CITRATE

Common Name

English

E-331(III)

Code

English

SODIUM CITRATE [MI]

Common Name

English

ANHYDROUS TRISODIUM CITRATE [USP MONOGRAPH]

Common Name

English

CITRIC ACID, TRISODIUM SALT

Common Name

English

CITROSODINE

Common Name

English

1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, TRISODIUM SALT

Common Name

English

SODIUM CITRATE ANHYDROUS

Common Name

English

SODIUM CITRATE ANHYDROUS [HSDB]

Common Name

English

FEMA NO. 3026, ANHYDROUS-

Code

English

NATRII CITRAS [WHO-IP LATIN]

Common Name

English

SODIUM CITRATE [WHO-IP]

Common Name

English

SODIUM CITRATE,ANHYDROUS [VANDF]

Common Name

English

SODIUM CITRATE, ANHYDROUS [WHO-IP]

Common Name

English

TRISODIUM CITRATE, ANHYDROUS

Common Name

English

INS-331(III)

Code

English

SODIUM CITRATE, ANHYDROUS

Common Name

English

ANHYDROUS SODIUM CITRATE

Common Name

English

NATROCITRAL

Common Name

English

TRISODIUM-CITRATE

Systematic Name

English

ANHYDROUS TRISODIUM CITRATE [II]

Common Name

English

INS NO.331(III)

Code

English

Classification Tree Code System Code

JECFA EVALUATION

INS-331(III)