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Details

Stereochemistry ACHIRAL
Molecular Formula C6H5O7.Cr
Molecular Weight 241.0958
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHROMIC CITRATE

SMILES

[Cr+3].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

InChIKey=SWXXYWDHQDTFSU-UHFFFAOYSA-K
InChI=1S/C6H8O7.Cr/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3

HIDE SMILES / InChI
Molecular Formula Cr
Molecular Weight 51.9961
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C6H5O7
Molecular Weight 189.0997
Charge -3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Chromium sulfate(III) hexahydrate or chromium sulphate, a trivalent compound of chromium that was investigated as a toxic compound. Experiments on rodent have shown chromium sulfate produced severe and widespread effects in the nasal cavity, larynx, lungs, and mediastinal lymph node. Effects were characterized by the accumulation of foreign material, infiltration of alveolar macrophages, septal cell hyperplasia, and granulomatous and chronic inflammation. Besides, chromium sulphate exerted a disadvantageous effect on the skeleton, as it decreases bone density and resistance.

Approval Year

1986
107
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1447
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Approved
8583
CHROMIUM

Approved Use

Chromium 4 mcg/mL (Chromic Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition. Administration helps to maintain chromium serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.

Launch Date

2005
PubMed

PubMed

TitleDatePubMed
The peripheral quantitative computed tomographic and densitometric analysis of skeletal tissue in male Wistar rats after chromium sulfate treatment.
2017-09-21
Effects of subchronic exposure via drinking water to a mixture of eight water-contaminating metals: a biochemical and histopathological study in male rats.
2007-11
Immunosuppressive effect of subchronic exposure to a mixture of eight heavy metals, found as groundwater contaminants in different areas of India, through drinking water in male rats.
2007-10
Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium.
2007-08
The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+.
2005-12-01
Status of antioxidant defense system in chromium-induced Swiss mice tissues.
2004-07
Thirteen-week subchronic rat inhalation toxicity study with a recovery phase of trivalent chromium compounds, chromic oxide, and basic chromium sulfate.
1999-12
Activation of MAPKs in human bronchial epithelial cells exposed to metals.
1998-09
Silicate antibodies in women with silicone breast implants: development of an assay for detection of humoral immunity.
1996-03
Cytokine induction in human epidermal keratinocytes exposed to contact irritants and its relation to chemical-induced inflammation in mouse skin.
1994-06
Patents

Patents

20010006640
24
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:59:24 GMT 2025
Edited
by admin
on Mon Mar 31 19:59:24 GMT 2025
Record UNII
LQC76G8WUE
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHROMIUM(III) CITRATE
WHO-DD  
Preferred Name English
CHROMIC CITRATE
Common Name English
CHROMIUM(3+) CITRATE
Systematic Name English
CITRIC ACID, CHROMIUM SALT
Common Name English
Chromium(III) citrate [WHO-DD]
Common Name English
1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, CHROMIUM(3+) SALT (1:1)
Systematic Name English
1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, CHROMIUM(3+) SALT
Systematic Name English
CHROMIUM CITRATE
Systematic Name English
Code System Code Type Description
PUBCHEM
6453431
Created by admin on Mon Mar 31 19:59:24 GMT 2025 , Edited by admin on Mon Mar 31 19:59:24 GMT 2025
PRIMARY
FDA UNII
LQC76G8WUE
Created by admin on Mon Mar 31 19:59:24 GMT 2025 , Edited by admin on Mon Mar 31 19:59:24 GMT 2025
PRIMARY
EVMPD
SUB130398
Created by admin on Mon Mar 31 19:59:24 GMT 2025 , Edited by admin on Mon Mar 31 19:59:24 GMT 2025
PRIMARY
CAS
57072-40-9
Created by admin on Mon Mar 31 19:59:24 GMT 2025 , Edited by admin on Mon Mar 31 19:59:24 GMT 2025
NON-SPECIFIC STOICHIOMETRY
ECHA (EC/EINECS)
260-543-6
Created by admin on Mon Mar 31 19:59:24 GMT 2025 , Edited by admin on Mon Mar 31 19:59:24 GMT 2025
PRIMARY
SMS_ID
100000156464
Created by admin on Mon Mar 31 19:59:24 GMT 2025 , Edited by admin on Mon Mar 31 19:59:24 GMT 2025
PRIMARY
DRUG BANK
DB14526
Created by admin on Mon Mar 31 19:59:24 GMT 2025 , Edited by admin on Mon Mar 31 19:59:24 GMT 2025
PRIMARY
EPA CompTox
DTXSID10205685
Created by admin on Mon Mar 31 19:59:24 GMT 2025 , Edited by admin on Mon Mar 31 19:59:24 GMT 2025
PRIMARY
RXCUI
407906
Created by admin on Mon Mar 31 19:59:24 GMT 2025 , Edited by admin on Mon Mar 31 19:59:24 GMT 2025
PRIMARY RxNorm
Related Record Type Details
Structure of CHROMIC CITRATE HEXAHYDRATE
SOLVATE->ANHYDROUS
Structure of Anhydrous citric acid
PARENT -> SALT/SOLVATE
Structure of CHROMIC CATION
PARENT -> SALT/SOLVATE
NIH
NCATS
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