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Details

Stereochemistry ACHIRAL
Molecular Formula C6H5O7.2Na.H
Molecular Weight 236.0874
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DISODIUM HYDROGEN CITRATE

SMILES

C(C(=O)[O-])C(CC(=O)[O-])(C(=O)O)O.[Na+].[Na+]

InChI

InChIKey=CEYULKASIQJZGP-UHFFFAOYSA-L
InChI=1S/C6H8O7.2Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula H
Molecular Weight 1.0079
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H5O7
Molecular Weight 189.1
Charge -3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: Description was created based on several sources, including http://www.adm.com/en-US/worldwide/australia/Documents/Potassium%20Citrate%20AU.pdf | https://noshly.com/additive/e332/acidity-regulator-plus/332/#.WUp-1uvyjIU

Potassium citrate is indicated for the management of renal tubular acidosis with calcium stones, hypocitraturic calcium oxalate nephrolithiasis of any etiology, uric acid lithiasis with or without calcium stones. WhenPotassium citrate is given orally, the metabolism of absorbed citrate produces an alkaline load. The induced alkaline load in turn increases urinary pH and raises urinary citrate by augmenting citrate clearance without measurably altering ultrafilterable serum citrate. Thus, potassium citrate therapy appears to increase urinary citrate principally by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. Potassium citrate is used as a food additive (E 332) to regulate acidity.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
UROCIT-K

Approved Use

Urocit®-K is a citrate salt of potassium indicated for the management of: • Renal tubular acidosis (RTA) with calcium stones • Hypocitraturic calcium oxalate nephrolithiasis of any etiology • Uric acid lithiasis with or without calcium stones

Launch Date

4.94121615E11
Primary
UROCIT-K

Approved Use

Urocit®-K is a citrate salt of potassium indicated for the management of: • Renal tubular acidosis (RTA) with calcium stones • Hypocitraturic calcium oxalate nephrolithiasis of any etiology • Uric acid lithiasis with or without calcium stones

Launch Date

4.94121615E11
Doses

Doses

DosePopulationAdverse events​
540 mg 1 times / day multiple, oral
Recommended
Dose: 540 mg, 1 times / day
Route: oral
Route: multiple
Dose: 540 mg, 1 times / day
Co-administed with::
Thiamin oral 1.1 mg
Arginine oral 1240 mg
caffeine oral 52 mg
Sources: Page: p.2326
healthy, 24-59
n = 16
Health Status: healthy
Age Group: 24-59
Sex: M+F
Population Size: 16
Sources: Page: p.2326
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Comparative efficacy of "specific" potassium citrate therapy versus conservative management in nephrolithiasis of mild to moderate severity.
1985 Oct
Renal hypouricemia due to enhanced tubular secretion of urate associated with urolithiasis: successful treatment of urolithiasis by alkalization of urine K+, Na(+)-citrate.
1993
[Therapeutic use of potassium citrate].
2001
Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.
2013 Jun
Patents

Sample Use Guides

In Vivo Use Guide
Objective: To restore normal urinary citrate (greater than 320 mg/day and as close to the normal mean of 640 mg/day as possible), and to increase urinary pH to a level of 6.0 to 7.0. • Severe hypocitraturia (urinary citrate < 150 mg/day): therapy should be initiated at 60 mEq per day; a dose of 30 mEq two times per day or 20 mEq three times per day with meals or within 30 minutes after meals or bedtime snack • Mild to moderate hypocitraturia (urinary citrate >150 mg/day): therapy should be initiated at 30 mEq per day; a dose of 15 mEq two times per day or 10 mEq three times per day with meals or within 30 minutes after meals or bedtime snack
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 15:06:14 UTC 2021
Edited
by admin
on Sat Jun 26 15:06:14 UTC 2021
Record UNII
6FO62KCQ7A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DISODIUM HYDROGEN CITRATE
HSDB  
Systematic Name English
CITRIC ACID, DISODIUM SALT
Common Name English
CITRIC ACID DISODIUM SALT
MI  
Common Name English
CITRIC ACID DISODIUM SALT [MI]
Common Name English
SODIUM CITRATE ACID
WHO-DD  
Common Name English
ANHYDROUS DISODIUM CITRATE
Common Name English
SODIUM ACID CITRATE [MART.]
Common Name English
SODIUM ACID CITRATE
MART.  
Common Name English
SODIUM CITRATE ACID [WHO-DD]
Common Name English
DISODIUM HYDROGEN CITRATE [HSDB]
Common Name English
DISODIUM CITRATE
Systematic Name English
Code System Code Type Description
NCI_THESAURUS
C83678
Created by admin on Sat Jun 26 15:06:14 UTC 2021 , Edited by admin on Sat Jun 26 15:06:14 UTC 2021
PRIMARY
FDA UNII
6FO62KCQ7A
Created by admin on Sat Jun 26 15:06:14 UTC 2021 , Edited by admin on Sat Jun 26 15:06:14 UTC 2021
PRIMARY
ECHA (EC/EINECS)
205-623-3
Created by admin on Sat Jun 26 15:06:14 UTC 2021 , Edited by admin on Sat Jun 26 15:06:14 UTC 2021
PRIMARY
EVMPD
SUB21691
Created by admin on Sat Jun 26 15:06:14 UTC 2021 , Edited by admin on Sat Jun 26 15:06:14 UTC 2021
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Sat Jun 26 15:06:14 UTC 2021 , Edited by admin on Sat Jun 26 15:06:14 UTC 2021
CONCEPT Industrial Aid
HSDB
375
Created by admin on Sat Jun 26 15:06:14 UTC 2021 , Edited by admin on Sat Jun 26 15:06:14 UTC 2021
PRIMARY
RXCUI
1366889
Created by admin on Sat Jun 26 15:06:14 UTC 2021 , Edited by admin on Sat Jun 26 15:06:14 UTC 2021
PRIMARY RxNorm
EVMPD
SUB91628
Created by admin on Sat Jun 26 15:06:14 UTC 2021 , Edited by admin on Sat Jun 26 15:06:14 UTC 2021
PRIMARY
PUBCHEM
8950
Created by admin on Sat Jun 26 15:06:14 UTC 2021 , Edited by admin on Sat Jun 26 15:06:14 UTC 2021
PRIMARY
MERCK INDEX
M3595
Created by admin on Sat Jun 26 15:06:14 UTC 2021 , Edited by admin on Sat Jun 26 15:06:14 UTC 2021
PRIMARY Merck Index
CAS
144-33-2
Created by admin on Sat Jun 26 15:06:14 UTC 2021 , Edited by admin on Sat Jun 26 15:06:14 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY