Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H19N3O.C6H8O7 |
Molecular Weight | 437.4437 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)CCC1=NC(=NO1)C2=CC=CC=C2
InChI
InChIKey=RBZIGQJSMCOHSS-UHFFFAOYSA-N
InChI=1S/C14H19N3O.C6H8O7/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-9H,3-4,10-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
Molecular Formula | C6H8O7 |
Molecular Weight | 192.1235 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C14H19N3O |
Molecular Weight | 245.3202 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Oxolamine under brand names Symphocal, Perebron is used in some countries as a cough suppressant for the treatment of pharyngitis, tracheitis, bronchitis, bronchiectasis, pertussis. Oxolamine possesses anti-inflammatory activity, which causes a reduction in the irritation of the nervous receptors of the respiratory tract.
Approval Year
Doses
Dose | Population | Adverse events |
---|---|---|
15 mL single, oral Overdose |
unhealthy, CHILD Health Status: unhealthy Age Group: CHILD Sex: M Food Status: UNKNOWN Sources: |
Disc. AE: Visual hallucinations... AEs leading to discontinuation/dose reduction: Visual hallucinations Sources: |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Visual hallucinations | Disc. AE | 15 mL single, oral Overdose |
unhealthy, CHILD Health Status: unhealthy Age Group: CHILD Sex: M Food Status: UNKNOWN Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
Effect of oxolamine on cough sensitivity in COPD patients. | 2002 Jan |
|
Effect of oxolamine on anticoagulant effect of warfarin. | 2006 Jan 15 |
|
Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats. | 2007 Apr |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:17:25 GMT 2025
by
admin
on
Mon Mar 31 19:17:25 GMT 2025
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Record UNII |
K5X4XBR694
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Record Status |
Validated (UNII)
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217-760-6
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1949-20-8
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759304
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16045
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SUB03576MIG
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DTXSID9045556
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K5X4XBR694
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m8313
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59053
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100000085508
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C008735
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |