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Details

Stereochemistry ACHIRAL
Molecular Formula 2C6H4O7.Bi.5K.3H2O
Molecular Weight 834.7018
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BISMUTH SUBCITRATE POTASSIUM

SMILES

C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])[O-].C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])[O-].[Bi+3].[K+].[K+].[K+].[K+].[K+].O.O.O

InChI

InChIKey=VBVVJMZCAZRTKA-UHFFFAOYSA-H
InChI=1S/2C6H7O7.Bi.5K.3H2O/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;;;;;/h2*1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;;;;3*1H2/q2*-1;+3;5*+1;;;/p-6

HIDE SMILES / InChI

Molecular Formula Bi
Molecular Weight 208.9804
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H6O7
Molecular Weight 190.1079
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: description was created based on several sources, including https://www.drugs.com/international/bibrocathol.html | https://clinicaltrials.gov/ct2/show/NCT01357538 | https://www.drugs.com/international/noviform.html | https://www.ncbi.nlm.nih.gov/pubmed/17003947

Bibrocathol (trade names Noviform and Posiformin) is a well-established topical antiseptic for the treatment of acute eyelid diseases like blepharitis. Eye ointments containing 2 or 5 % bibrocathol and the excipients liquid paraffin, white soft paraffin, and lanolin have been marketed since 1967 for the treatment of eye irritation, chronic blepharitis, and uninfected corneal injuries. Reports of clinical experience with bibrocathol for inflammation of the edge of the palpebra exist since the beginning of the 20th century. Until recently, no controlled, randomized clinical studies according to the guidelines for Good Clinical Practice for Trials on Medical Products for Human Use (GCP) as defined by the International Conference on Harmonisation (ICH) have been performed with bibrocathol 2 % ointment, as these were not required for marketing authorization in the 1960s. A first double-blind, prospective, controlled, GCP-compliant clinical study was recently performed to assess the efficacy of bibrocathol 5 % (Noviform®) in acute blepharitis. It demonstrated superior efficacy of bibrocathol 5 % ointment as compared to an ointment vehicle (placebo) after 2 weeks of treatment as assessed by a combined measure of slit-lamp examination results and patients’ subjective complaints.

Originator

Sources: Medizinische Klinik (Muenchen, Germany) (1913), 8, 992.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Noviform

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Successful treatment of blepharitis with bibrocathol (Posiformin® 2 %).
2012 Dec
Patents

Sample Use Guides

A strip of 5 mm eye ointment applied 3 times per day to the eye lid
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 01:53:51 UTC 2021
Edited
by admin
on Sat Jun 26 01:53:51 UTC 2021
Record UNII
R3O80H60KX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BISMUTH SUBCITRATE POTASSIUM
MART.   ORANGE BOOK   USAN   WHO-DD  
USAN  
Official Name English
BISMUTH SUBCITRATE POTASSIUM [USAN]
Common Name English
BISMUTH SUBCITRATE POTASSIUM [ORANGE BOOK]
Common Name English
BISMUTH PENTAPOTASSIUM DIHYDROXIDE BIS(2-HYDROXYPROPANE-1,2,3-TRICARBOXYLATE HYDRATE
Systematic Name English
PYLERA COMPONENT BISMUTH SUBCITRATE POTASSIUM
Brand Name English
1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, BISMUTH(3+) POTASSIUM SALT HYDRATE (2:1:5:3)
Systematic Name English
1001277
Code English
BISMUTH SUBCITRATE POTASSIUM COMPONENT OF PYLERA
Brand Name English
BISMUTH SUBCITRATE POTASSIUM [MART.]
Common Name English
BISMUTH SUBCITRATE POTASSIUM [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C52588
Created by admin on Sat Jun 26 01:53:51 UTC 2021 , Edited by admin on Sat Jun 26 01:53:51 UTC 2021
Code System Code Type Description
EVMPD
SUB34603
Created by admin on Sat Jun 26 01:53:51 UTC 2021 , Edited by admin on Sat Jun 26 01:53:51 UTC 2021
PRIMARY
RXCUI
1294617
Created by admin on Sat Jun 26 01:53:51 UTC 2021 , Edited by admin on Sat Jun 26 01:53:51 UTC 2021
PRIMARY RxNorm
DRUG BANK
DB09275
Created by admin on Sat Jun 26 01:53:51 UTC 2021 , Edited by admin on Sat Jun 26 01:53:51 UTC 2021
PRIMARY
FDA UNII
R3O80H60KX
Created by admin on Sat Jun 26 01:53:51 UTC 2021 , Edited by admin on Sat Jun 26 01:53:51 UTC 2021
PRIMARY
NCI_THESAURUS
C87451
Created by admin on Sat Jun 26 01:53:51 UTC 2021 , Edited by admin on Sat Jun 26 01:53:51 UTC 2021
PRIMARY
PUBCHEM
91667752
Created by admin on Sat Jun 26 01:53:51 UTC 2021 , Edited by admin on Sat Jun 26 01:53:51 UTC 2021
PRIMARY
ChEMBL
CHEMBL1201186
Created by admin on Sat Jun 26 01:53:51 UTC 2021 , Edited by admin on Sat Jun 26 01:53:51 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY